Efficacy of fixed combinations of acetylsalicyclic acid, acetaminophen and caffeine in the treatment of idiopathic headache: a review

Anneken, K.; Evers, Stefan; Husstedt, IW

doi:10.1111/j.1468-1331.2009.02922.x

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…Die Kombination mehrerer Wirkstoffe kann grundsätzlich den Therapieerfolg positiv beeinflussen. Dies erklärt sich durch eine Erhöhung der Ansprechrate, der Ansprechwahrscheinlichkeit, der Konsistenz, des Ausmaßes der Breite oder der Dauer der Symptomverbesserung oder durch eine Verbesserung der Verträglichkeit (24,33,34). Dieser Synergismus therapeutischer Vorteile ergibt sich aus den unterschiedlichen oder komplementären Wirkmechanismen der kombinierten Wirkstoffe, die multiple biologische Prozesse induzieren (25).…”

Section: Rationale Koffeinhaltiger Kombinationspräparateunclassified

Stellenwert der fixen Kombination aus Acetylsalicylsäure, Paracetamol und Koffein in der Therapie primärer Kopfschmerzen

Haag¹,

Wessely²,

Lampl³

2014

Nervenheilkunde

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ZusammenfassungEssenzieller Bestandteil der Selbstmedikation primärer Kopfschmerzerkrankungen sind Kombinationsanalgetika, die Acetylsalicylsäure, Paracetamol und Koffein enthalten. Sie sind den Monosubstanzen Acetylsalicylsäure, Paracetamol, Ibuprofen und Sumatriptan in ihrer Wirksamkeit überlegen. Durch die Kombination mehrerer Wirkstoffe und des Koffeins als Adjuvans erklärt sich die Erhöhung der Ansprechrate, der Ansprechwahrscheinlichkeit, der Konsistenz und des Ausmaßes sowie der Dauer der Symptomverbesserung. Durch die Dosisreduktion der Einzelsubstanzen wird eine Verbesserung des Sicherheits- und Verträglichkeitsprofils erreicht. Bedenken, dass Kombinationsanalgetika eine Analgetikanephropathie induzieren oder unterhalten würden, sind widerlegt und konnten ursächlich dem Phenacetin zugeordnet werden, das in Westeuropa verboten ist. Für ein höheres Risiko der Entwicklung eines Medikamentenübergebrauchkopfschmerzes bzw. eines nicht bestimmungsgemäßen Mehr- oder Vielgebrauchs durch Koffein ergibt sich aus den Studien keine wissenschaftliche Evidenz.

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Section: Rationale Koffeinhaltiger Kombinationspräparateunclassified

Stellenwert der fixen Kombination aus Acetylsalicylsäure, Paracetamol und Koffein in der Therapie primärer Kopfschmerzen

Haag¹,

Wessely²,

Lampl³

2014

Nervenheilkunde

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“…Therefore, when caffeine is added to other analgesics (eg, drinking a cup of coffee or using combined tablets of caffeine with aspirin, ibuprofen, or ergots) their effect increases, but the risk of dependence and overuse increases too 56,57…”

Section: Management Of Nausea and Vomiting In Migrainementioning

confidence: 99%

Optimal management of severe nausea and vomiting in migraine: improving patient outcomes

Láinez¹,

García-Casado²,

Gascón³

2013

PROM

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Migraine is a common and potentially disabling disorder for patients, with wide-reaching implications for health care services, society, and the economy. Nausea and vomiting during migraine attacks are common symptoms that affect at least 60% of patients suffering from migraines. These symptoms are often more disabling than the headache itself, causing a great burden on the patient’s life. Nausea and vomiting may delay the use of oral abortive medication or interfere with oral drug absorption. Therefore, they can hinder significantly the management and treatment of migraine (which is usually given orally). The main treatment of pain-associated symptoms of migraine (such as nausea and vomiting) is to stop the migraine attack itself as soon as possible, with the effective drugs at the effective doses, seeking if necessary alternative routes of administration. In some cases, intravenous antiemetic drugs are able to relieve a migraine attack and associated symptoms like nausea and vomiting. We performed an exhaustive PubMed search of the English literature to find studies about management of migraine and its associated symptoms. Search terms were migraine, nausea, and vomiting. We did not limit our search to a specific time period. We focused on clinical efficacy and tolerance of the various drugs and procedures based on data from human studies. We included the best available studies for each discussed drug or procedure. These ranged from randomized controlled trials for some treatments to small case series for others. Recently updated books and manuals on neurology and headache were also consulted. We herein review the efficacy of the different approaches in order to manage nausea and vomiting for migraine patents.

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“…After long‐term use in a high proportion of patients, their improved general well‐being and mood became the primary indications for drug use (Zhang & Po , Anneken et al . ).…”

Section: Introductionmentioning

confidence: 97%

The use of nonsteroidal anti‐inflammatory drugs and analgesics by liver transplant recipients

Mulka-Gierek

Foroncewicz

Florczak

et al. 2016

Journal of Clinical Nursing

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Considering the high NSAIDs consumption rates, the side effects of these drugs should always be suspected. Especially in patients taking these drugs and referring to medical advisors with specific symptoms, such as: abdominal pain, anaemia, elevated serum creatinine concentration or liver enzymes activity. Awareness of the scale of the problem enables health professionals to cooperate in educating patients. Such practices may reduce uncontrolled abuse of these drugs and related health care costs.

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Efficacy of fixed combinations of acetylsalicyclic acid, acetaminophen and caffeine in the treatment of idiopathic headache: a review

Cited by 14 publications

References 42 publications

Stellenwert der fixen Kombination aus Acetylsalicylsäure, Paracetamol und Koffein in der Therapie primärer Kopfschmerzen

Stellenwert der fixen Kombination aus Acetylsalicylsäure, Paracetamol und Koffein in der Therapie primärer Kopfschmerzen

Optimal management of severe nausea and vomiting in migraine: improving patient outcomes

The use of nonsteroidal anti‐inflammatory drugs and analgesics by liver transplant recipients

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