Efficacy of Fluopicolide against Phytophthora capsici Causing Pepper Phytophthora Blight

Shin, Jin Ho; Kim, Joo Hyung; Kim, Hyung Jo; Kang, Bum Gwan; Kim, Kyeong Tae; Lee, Jeong Deug; Kim, Heung Tae

doi:10.5423/ppj.2010.26.4.367

Cited by 10 publications

(3 citation statements)

References 3 publications

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“…Ethaboxam (Cortright et al 2016;Kim et al 2004), fluopicolide and mandipropamid (Cerkauskas et al 2015;Foster and Hausbeck 2010;Jackson et al 2010;Jiang et al 2015;Meyer and Hausbeck 2013;Shin et al 2010), and oxathiapiprolin (Bittner and Mila 2016;Ji and Csinos 2015;Ji et al 2014;Miao et al 2016) were previously shown to provide a high level of control for a range of foliar and root diseases of field and vegetable crops caused by species of Phytophthora. However, our study is the first validation of the effective use of the new compounds on a perennial tree crop, and the results presented are facilitating their registration on citrus.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of New Oomycota Fungicides for Management of Phytophthora Root Rot of Citrus in California

et al. 2019

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Phytophthora root rot, caused by several species of Phytophthora, is an important disease of citrus in California and other growing regions. For chemical management, mefenoxam and potassium phosphite have been available for many years, and resistance in Phytophthora spp. has been reported for both compounds. We evaluated the efficacy of the new Oomycota fungicides ethaboxam, fluopicolide, mandipropamid, and oxathiapiprolin, each with a different mode of action, against Phytophthora root rot of citrus in field and greenhouse studies. Root balls of navel orange trees on ‘Carrizo citrange’ rootstock were inoculated with P. nicotianae at planting in the field in fall 2013. Applications with 11 fungicide treatments were made 5 weeks after planting, in spring and fall 2014, and in spring 2015. Feeder roots and adjacent soil were collected before or after application. All of the new fungicides significantly reduced root rot incidence and Phytophthora soil populations to very low levels as compared with the control starting after the first application. Mefenoxam was only effective when a high label rate was used in the fourth application. Selected treatments also increased tree canopy size, trunk diameter, and fruit yield as compared with the control. A rate comparison with the four new fungicides was initiated in summer 2016 in another field trial using navel orange trees inoculated with P. citrophthora. Minimum effective rates to reduce Phytophthora root rot incidence and pathogen soil populations were determined after one and two applications in fall 2016 and summer 2017, respectively. Greenhouse studies confirmed the efficacy of the new fungicides. Based in part on our studies, fluopicolide recently received a federal and oxathiapiprolin a full registration for use on citrus, and registrations for ethaboxam and mandipropamid have been requested. These new compounds will provide highly effective treatment options and resistance management strategies using rotation and mixture programs for the control of Phytophthora root rot of citrus.

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Section: Discussionmentioning

confidence: 99%

Evaluation of New Oomycota Fungicides for Management of Phytophthora Root Rot of Citrus in California

et al. 2019

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“…Carboxamide derivatives have attracted continuous concern because of their broad therapeutic windows 22 . Notably, the amide groups are also generally present in numerous commercial fungicides as crucial pharmacophores; for example, diclocymet, 23 carpropamid, 24 isoflucypram, 25 fluopimomide, 26 fluopicolide, 27 and tolfenpyrad 28 (Figure 1b). Meanwhile, compared with the amide group, the hydrazide group is also widely used in the design of many agrochemicals 29 including the insecticides RH‐5849, 30 tebufehozide 31 and chromafenozide, 32 and the fungicides famoxadone, 33 fenamidone 34 and meixiuyihao 35 (Figure 1c).…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and antifungal evaluation of novel nopol derivatives as potent laccase inhibitors

Sun

Jin

et al. 2023

Pest Management Science

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BACKGROUND To explore further potential natural product‐based antifungal agents, a series of novel nopol‐based carboxamide and hydrazide derivatives containing a natural pinene structure were designed, synthesized, and evaluated for their inhibitory activities against seven phytopathogenic fungi and oomycetes. RESULTS The bioassay results indicated that some compounds exhibited good inhibitory activities against Gibberella zeae, Sclerotinia sclerotiorum, and Phytophthora capsici. Among them, compound 3h displayed excellent in vitro activities against G. zeae, with EC50 values of 1.09 mg L−1, which was comparable with the commercial fungicides bixafen and carbendazim (median effective concentration [EC50] = 1.21 and 0.89 mg L−1, respectively). Notably, in vivo bioassay results suggested that compound 3h also showed prominent protective and curative effects (95.6% and 94.2%) at 200 mg L−1 against G. zeae. The scanning electron microscopy study indicated that compound 3h could destroy the morphological integrity of G. zeae hyphae. The in vitro enzyme inhibitory bioassay revealed that compound 3h exhibited potent inhibitory activity against laccase with median inhibitory concentration (IC50) values of 4.93 μm, superior to positive control cysteine (IC50 = 35.50 μm), and its binding modes with laccase were elucidated by molecular docking study. In addition, the fluorescent imaging of the dansylamide‐labeled derivatives 8 on wheat leaf epidermal cells and the hyphae of G. zeae revealed that this class of hydrazide derivatives could readily permeate into wheat leaves and reached the laccase target in fungal cells. CONCLUSION Some nopol‐based hydrazide derivatives exhibited excellent anti‐G. zeae activity and laccase inhibitory activity, which merits further development as a new fungicide candidate for controlling Fusarium head blight. © 2023 Society of Chemical Industry.

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“…This study sought to screen additional anti-oomycete fungicides, which have been successful in reducing disease incidence and severity in predominantly agricultural instances of Phytophthora spp. diseases (Zhang et al 2005, Shin et al 2010.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity of the soil-borne pathogen Phytophthora agathidicida, the causal agent of kauri dieback, to the anti-oomycete fungicides ethaboxam, fluopicolide, mandipropamid, and oxathiapiprolin

Thurston

Waller

Condron

et al. 2022

NZPP

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The oomycete Phytophthora agathidicida is the causal agent of kauri dieback, which threatens the survival of endemic kauri (Agathis australis) forests in Aotearoa|New Zealand. Current chemical control of P. agathidicida involves the application of either a mixture of halogenated tertiary amines or phosphite salts with some success, but neither treatment cures the disease. Recently, four anti-oomycete fungicides, all with different modes of action, have become commercially available. Here, we determined the inhibition potential of these fungicides on three P. agathidicida isolates, using agar dilution assays. The average concentration required to inhibit mycelial growth by 50% (EC50) for ethaboxam, fluopicolide, and mandipropamid was 0.0916, 0.372, and 0.0196 µg/mL, respectively. Inhibition of P. agathidicida mycelia by oxathiapiprolin and its commercial formulation, Zorvec® Enicade®, was 0.000152 and 0.000309 µg/mL, respectively. Based on the EC50 values reported in this study, these fungicides are the most effective inhibitors of P. agathidicida mycelia when compared to previously screened fungicides, natural products, and plant extracts. Thus, their performance in this initial screening supports further research into their potential use as a kauri dieback management tool.

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Efficacy of Fluopicolide against Phytophthora capsici Causing Pepper Phytophthora Blight

Cited by 10 publications

References 3 publications

Evaluation of New Oomycota Fungicides for Management of Phytophthora Root Rot of Citrus in California

Evaluation of New Oomycota Fungicides for Management of Phytophthora Root Rot of Citrus in California

Design, synthesis and antifungal evaluation of novel nopol derivatives as potent laccase inhibitors

Sensitivity of the soil-borne pathogen Phytophthora agathidicida, the causal agent of kauri dieback, to the anti-oomycete fungicides ethaboxam, fluopicolide, mandipropamid, and oxathiapiprolin

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