Efficacy of fresh frozen plasma transfusion in comparison with conventional regimen in organophosphate poisoning treatment: a meta-analysis study

Gheshlaghi, Farzad; Savari, Mahsa Akafzadeh; Nasiri, Rozita; Wong, Andy; Feizi, Awat; Maracy, Mohammad Reza; Dorooshi, Gholamali; Meamar, Rokhsareh; Eizadi-Mood, Nastaran

doi:10.1080/10408444.2020.1823313

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…A 45-year-old farmer with a body mass index = 22.1 (BMI = weight (kg)/height 2 (m)) who was referred to the poisoning emergency center of Khorshid Hospital affiliated to Isfahan University of Medical Sciences about 6 days after the skin exposure through accidental spraying PQ 20% solution on his face and body. He suffered from dysphagia, two episodes of hemoptysis containing clear blood clots, and respiratory distress which was started 3 days after exposure.…”

Section: Case Reportmentioning

confidence: 99%

“… 1 It was also consumed broadly as pesticides for agricultural purposes. 1 , 2 Due to its low cost and high efficiency, it is still widely utilized in many countries, especially in Asian and developing countries, and approximately, people are poisoned by about 2000 annually. 3 , 4 PQ has a high toxicity and mortality rate, in adults causes death of about 3–6 g of it.…”

Section: Introductionmentioning

confidence: 99%

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Rare fatal poisoning through dermal exposure to paraquat

Eizadi-Mood

Haddad

Mirmoghtadaei

et al. 2022

SAGE Open Medical Case Reports

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Paraquat skin contact occurs less frequently and is rarely fatal. This article reports a case of a 45-year-old man who presented with dysphagia, respiratory distress and grade two, and third skin burns focusing on the upper body after accidental exposure to paraquat. He was admitted to the hospital 6 days after the first contact. The urine sodium dithionate test was strongly positive. The O2 saturation at admission was 52%, which reached 91% with a bag valve mask. Rising blood liver enzymes, urea, creatinine, and respiratory acidosis in the venous blood gas analysis were observed in the lab data. In the course of hospitalization, the patient was intubated due to oxygen level dropping. Evidence of acute respiratory distress syndrome and decreased level of consciousness was also observed. However, despite treatment with corticosteroids, antioxidants, and hemodialysis, he died on the fourth day of hospitalization. It is concluded that dermal exposure with paraquat could be life-threatening if the patient presented late with organ involvement.

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Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rare fatal poisoning through dermal exposure to paraquat

Eizadi-Mood

Haddad

Mirmoghtadaei

et al. 2022

SAGE Open Medical Case Reports

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“…Some organophosphorus pesticides (OPs) are extremely poisonous and cause rapid intoxication-induced death with minimal ingestion or exposure. Acute organophosphorus pesticide poisoning (AOPP) is a major life-threatening toxic disease in the rural areas of developing countries ( 1 , 2 ). In China, AOPP cases comprise nearly 50% of all poisoning cases, with case fatality rates of 3–40%, comprising over 80% of all poisoning deaths ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical Analysis of Acute Organophosphorus Pesticide Poisoning and Successful Cardiopulmonary Resuscitation: A Case Series

Jian

et al. 2022

Front. Public Health

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Acute organophosphorus pesticide poisoning (AOPP) with cardiac arrest has an extremely high mortality rate, and corresponding therapeutic strategies have rarely been reported. Therefore, this study aimed to explore the prognostic factors and effective treatments of AOPP-related cardiac arrest. This retrospective study was conducted in our department in the years 2018–2021. We conducted a descriptive analysis of the clinical manifestations, rescue strategies, and prognosis of patients with AOPP who had experienced cardiac arrest and successful cardiopulmonary resuscitation. This study included six cases of patients with AOPP in addition to cardiac arrest; in four cases, cardiac arrest occurred <12 h after ingestion, and in two, cardiac arrest occurred more than 48 h after ingestion. Five patients had not undergone hemoperfusion therapy before cardiac arrest, and all six were treated with atropine during cardiopulmonary resuscitation and subsequent pralidoxine. Four patients recovered and were discharged from the hospital, one died in our department, and one was transferred to a local hospital and died there 2 h later. The last two patients had severe pancreatic injuries and disseminated intravascular coagulation. This, along with their death, might have been related to their prognosis. Cardiac arrest can occur in patients with severe AOPP for whom antidote administration was insufficient or not timely. Application of atropine and pralidoxine in a timely manner after cardiac arrest following AOPP is the key to successful treatment. This study provides useful guidelines for the treatment of similar cases in the future.

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Evaluation of the effectiveness of fresh frozen plasma transfusion as adjuvant treatment in acute organophosphate-poisoned patients: A randomized clinical trial

Abdelhamid,

Abel Kareem,

Ashry

et al. 2024

Hum Exp Toxicol

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Organophosphorus (OP) poisoning is a significant cause of morbidity and mortality worldwide. Recent research has explored new approaches to improving treatment options, which present several challenges. This study aimed to evaluate the role of fresh frozen plasma (FFP) as an adjunctive therapy for acute OP intoxication. A prospective single-blinded randomized clinical trial was conducted on patients of both sexes admitted to the Intensive Care Unit (ICU) of the Poison Control Center at Ain Shams University Hospital (PCC-ASUH) with acute OP toxicity during the period from the beginning of August 2022 to the end of July 2023. According to the Peradeniya score, Group I consisted of 48 patients (52%) with moderate OP poisoning, and Group II consisted of 44 patients (48%) with severe OP poisoning. Patients in the moderate group were assigned to receive either standard treatment (Group Ia, n = 24) or standard treatment plus FFP (Group Ib, n = 24). In addition, patients in the severe group were assigned to receive either standard treatment (Group IIa, n = 22) or standard treatment plus FFP (Group IIb, n = 22). A total of 46 patients received FFP transfusion. The authors demonstrated that the early use of a total of nine packs of FFP (250 mL each) over three consecutive days significantly reduced the total doses of atropine and oximes, the total hospitalization period, and the requirement for mechanical ventilation in patients with OP poisoning, both in the moderate and severe groups.

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Efficacy of fresh frozen plasma transfusion in comparison with conventional regimen in organophosphate poisoning treatment: a meta-analysis study

Cited by 4 publications

References 26 publications

Rare fatal poisoning through dermal exposure to paraquat

Rare fatal poisoning through dermal exposure to paraquat

Clinical Analysis of Acute Organophosphorus Pesticide Poisoning and Successful Cardiopulmonary Resuscitation: A Case Series

Evaluation of the effectiveness of fresh frozen plasma transfusion as adjuvant treatment in acute organophosphate-poisoned patients: A randomized clinical trial

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