Efficacy of Garcinia kola Seed Ethanolic Extract on Haematological Parameters in Male Wistar Rats

Denen, Atsukwei; Daniel, Eze Ejike; Odeh, SO; Adams, Moses Dele; Ibrahim, Malgwi; Olih, Patricia

doi:10.9734/jamps/2015/15305

Cited by 7 publications

(6 citation statements)

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“…However, our finding was similar to the results of Dada and Ikuerowo 24 who demonstrated that Garcinia kola failed to cause change in erythrocyte count and PCV over a dose range of 250 -2000 mg/kg. In addition, the extract in our study increased platelet count, which was consistent with the findings of Atsukwei et al, 25 , but in disagreement with Ahumibe et al, 22 where platelet count was reported to be unaffected by extract treatment.…”

Section: Resultssupporting

confidence: 86%

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2018

IJPSR

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Garcinia kola is a known herbal plant which is widely consumed for many ethnomedicinal uses. This study was aimed at determining the effect of ethanol extract of G. kola seeds on levels of hematological as well as blood indices of liver (aspartate transaminase, alanine transaminase, alkaline phosphatase, total protein, and albumin) and kidney function (creatinine and urea). Extract (50, 100, 200 or 300 mg/kg) was orally administered to different groups of rats (n = 6) daily for thirty days. Control animals were given vehicle (DMSO + distilled water, 2:1). Blood levels of the parameters mentioned above were measured at the end of extract treatment. Livers and kidneys of animals were removed and weighed and organ-to-body weight ratio was obtained. Extract had no effect on serum levels of liver and kidney indices, except that it reduced (P<0.05) ALP level at 300 mg/kg. Organ-to-body weight ratio of liver and kidney were not affected by extract. Furthermore, the extract increased (P<0.001) platelet count, but had no effect on RBC and its indices (mean cell volume, mean cell haemoglobin, and mean cell haemoglobin concentration), Hb and PCV compared to control. It also caused reduction (P<0.001) in WBC and neutrophil counts, while lymphocyte was increased. The result suggests that G. kola seed may have no adverse influence on hematologic, hepatic or renal system, and may additionally have hepato-protective property, and enhance blood clotting and lymphocyte function.

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Section: Resultssupporting

confidence: 86%

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2018

IJPSR

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“…Atsukwei et al (2015) reported a similar finding in ethanolic seed extract of G. kola in male wistar rats. This supports the relationship between haemoglobin and packed cell volume and suggests that the extract may improve erythropoiesis through mechanisms yet to be determined (Smith and Bidlack, 1980;Naidu, 2003).…”

Section: Discussionsupporting

confidence: 64%

Evaluation of some metabolic activities and immuno-stimulatory potential of methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats

Bukar¹,

Dayom²,

Okpeke³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Evaluation of some metabolic activities and immuno-stimulatory potential of the methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats was carried out using standard methods. Animals in treated groups were administered 125, 250 and 500 mg/kg body weight, respectively of the extract through the oral route for 21 days. The control group received normal saline (0.5 ml/100 g body weight) for the same period during which food and water intakes were monitored. At the end of the treatment period, complete and differential blood counts were evaluated for each group. Results show that the extract at the doses of 125 and 250 mg/kg caused significant increase in body weight of treated animals compared with those of control (p < 0.05). Similarly, there was significant increase in food and water intake as well as faecal and urine output in groups treated with 250 and 500 mg/kg (p < 0.05). Results of the complete blood count showed that the extract caused significant increase in total white blood cell count (WBC) (p < 0.05) but a non-significant increase in haemoglobin (p > 0.05). There was significant increase in lymphocytes in groups that received the extract at a dose of 125 mg/kg compared with control (p < 0.05). These results suggest that the methanolic seed extract of G. kola possesses immuno-stimulatory potential that may justify the ethno-medicinal claims of the efficacy of G. kola in treatment of some immune disorders.

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“…The extract significantly decreased the volume of the cell mean cell and hemoglobin cell means in the plasma of the animals ( p < 0.05). The ethanolic extract of G kola seed has hematological, stimulating, and enhancing effects due to its antioxidant qualities [ 40 ]. These findings suggest that it has no harmful effects on the liver's function and may have a beneficial effect, as indicated by its capacity to drastically lower total serum cholesterol and increase WBC count [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Biological Evaluation of Garcinia kola Heckel

Abdulrahman

Bradosty

Hama

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Garcinia kola belongs to the Garcinia genus of the Clusiaceae family and Malpighiales order. It contains more than 180 members all over the globe. It is found all over Asia and in tropical African countries. In Africa, traditionally, G kola is used to manage and treat cancer, diabetes, malaria, analgesics, hypertension, and other numerous ailments. This review aimed to comprehensively update relevant information regarding the pharmacological potential of Garcinia kola. Electronic databases such as ScienceDirect, PubMed, Wiley, Google Scholar, Hindawi, and Springer extracted valuable information from original scientific research papers. Inclusion Criteria. Antioxidant, antimicrobial, antidiabetic, antibacterial, medications, antiviral, traditional medicine, ethnopharmacology, toxicity, cytotoxic action, chemical composition, mineral elements, GCMS analysis, and any other related phrases were used as filters to find studies. Exclusion Criteria. Data from questionable online sources, as well as thesis reports and review publications, were excluded from this investigation. The investigation revealed that seeds of G. kola are very efficient as antioxidant, antimicrobial, antidiabetic, antihypertension, antianalgesic, and anti-inflammatory. The study also found that too much consumption of the seeds caused low fertility and toxicity. However, the safety and efficacy of G. kola have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the seed extract should be examined. The standard dose and safety of the seed should be established.

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Efficacy of Garcinia kola Seed Ethanolic Extract on Haematological Parameters in Male Wistar Rats

Cited by 7 publications

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Evaluation of some metabolic activities and immuno-stimulatory potential of methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats

Biological Evaluation of Garcinia kola Heckel

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