2020
DOI: 10.1007/s00784-020-03484-1
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Efficacy of gel-based artificial saliva on Candida colonization and saliva properties in xerostomic post-radiotherapy head and neck cancer patients: a randomized controlled trial

Abstract: Objective To evaluate the efficacy of an edible artificial saliva gel, oral moisturizing jelly (OMJ), and a topical commercial gel (GC dry mouth gel) on Candida colonization and saliva properties. Materials and methods This study was a secondary analysis of a single-blinded randomized controlled trial conducted in xerostomic post-radiotherapy head and neck cancer patients. Candida colonization, stimulated salivary flow rate (SSFR), saliva pH, and b… Show more

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Cited by 19 publications
(29 citation statements)
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“…Based on the 5 included articles [16][17][18][19][20], the most related conditions to dry mouth were not only in patients with systemic diseases such as Sjogren's syndrome [16], post-radiotherapy in head and neck cancer patients [18,20], diabetes mellitus [19], and patients using endotracheal tubes [19] but can also be found in non-Sjogren's syndrome patients. This article review completes the previously published review articles, which already stated that dry mouth or xerostomia could be related to aging [1,2,7,8,21], burning mouth syndrome [1], and medication-induced.…”
Section: Discussionmentioning
confidence: 99%
“…Based on the 5 included articles [16][17][18][19][20], the most related conditions to dry mouth were not only in patients with systemic diseases such as Sjogren's syndrome [16], post-radiotherapy in head and neck cancer patients [18,20], diabetes mellitus [19], and patients using endotracheal tubes [19] but can also be found in non-Sjogren's syndrome patients. This article review completes the previously published review articles, which already stated that dry mouth or xerostomia could be related to aging [1,2,7,8,21], burning mouth syndrome [1], and medication-induced.…”
Section: Discussionmentioning
confidence: 99%
“…The symptomatic relief or control of oral dryness includes hydration (frequent sipping of water), discontinuation or reduction in xerogenic medications, and elimination of common dry mouth offenders, such as tobacco and alcohol [ 76 ]. Moreover, artificial salivary substitutes (i.e., commercial products containing specific ingredients, whose properties resemble those of the natural saliva) are frequently used as symptomatic treatments for patients with decreased salivary flow rate [ 77 , 78 ]. In fact, they act as oral lubricants that maintain the lubrication of the mucosa and, hence, relieve the sensation of dryness, without stimulating the salivary flow.…”
Section: Management Of Xerostomiamentioning
confidence: 99%
“…After the accumulation of saliva, it's tested with an Electrolytes Analyzer, YACOi (Yarsan-India). Then the acidity was tested to start comparing the PH intervals of patients with oral candidiasis and control cases (Lam-ubol et al, 2021).…”
Section: Acidity Test Of Salivamentioning
confidence: 99%