Efficacy of ginger for treating Type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials

Daily, James W.; Yang, Mini; Kim, Da Sol; Park, Sunmin

doi:10.1016/j.jef.2015.02.007

Cited by 40 publications

(28 citation statements)

References 16 publications

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“…Ginger is one of the widely used spices and functional foods. The medicinal features attributed to ginger are anti-arthritic, anti-migraine, antithrombotic, anti-inflammatory, anti-nausea, antivomiting, hypolipidemic and analgesic properties [5,6].…”

Section: Introductionmentioning

confidence: 99%

Effect of ginger on the blood glucose level of women with gestational diabetes mellitus (GDM) with impaired glucose tolerance test (GTT): a randomized double-blind placebo-controlled trial

Hajimoosayi

Sadatmahalleh

Kazemnejad

et al. 2020

BMC Complement Med Ther

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Background: Gestational diabetes mellitus (GDM) is one the most common complications of pregnancy. The present work aimed at investigating the effect of ginger on the blood glucose level of GDM women with impaired glucose tolerance test (GTT). Methods: This randomized double-blind placebo-controlled clinical trial was performed on the total of 70 women with GDM, who were in 24-28 weeks of pregnancy with impaired GTT from 2015 to 2016. For this purpose, the women were assigned to two groups of ginger or placebo. The ginger group received 126 tablets of ginger, and the placebo group received 126 tablets of placebo for six weeks. The serum Blood Sugar 2 h post-prandial (BS2hpp), Fast Blood Sugar (FBS) and insulin, as well as Homeostasis Model Assessment (HOMA) index were analyzed before and six weeks after intervention. Results: The mean of FBS (P = 0.04), fasting insulin (P = 0.01), and HOMA index (P = 0.05) was reduced significantly in the ginger group six weeks after intervention in comparison to the placebo group. But the mean of BS2hpp did not show any significant reduction in the two groups (P > 0.05(. Conclusions: Oral administration of ginger tablet improved FBS, serum insulin and HOMA index in the women with GDM; however, it could not reduce their BS2hpp level. The trial has been registered in the Iranian Registry of Clinical Trials (IRCT2015090523897N1).

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Section: Introductionmentioning

confidence: 99%

Effect of ginger on the blood glucose level of women with gestational diabetes mellitus (GDM) with impaired glucose tolerance test (GTT): a randomized double-blind placebo-controlled trial

Hajimoosayi

Sadatmahalleh

Kazemnejad

et al. 2020

BMC Complement Med Ther

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“…A review by Daily and colleagues found that studies administering 1,600-3,000 mg of ginger powder per day for 8-12 weeks lowered fasting serum glucose levels and HbA1c levels in patients with Type 2 diabetes 23 . A study conducted in Saudi Arabia showed that raw ginger was significantly effective in lowering serum glucose, cholesterol and triacylglycerol in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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Background: Diabetes poses a burden on the limited health care delivery system. Current pharmacological anti-diabetic agents cause undesirable side effects and are very expensive. Herbal remedies offer the potential for alternative treatment strategies. This study was therefore conducted in an effort to formulate a poly herbal medicine for management of diabetes. Methods: A stenophylla root bark was extracted with aqueous ethanol (70%) and quantitative analysis for total phenolic content, total alkaloids and flavonoids was carried out on the dried extract. The hypoglycaemic effects of aqueous A. stenophylla root bark extract, powdered Zingiber officinale and powdered Citrus Limon peels was determined on alloxan-induced diabetic rats singly and in combinations over 14 days. Glibenclamide administered at 0.2 mg/kg b. wt was used as the positive control. Results: All the plants decreased plasma glucose levels in a dosedependent manner. The glucose levels of diabetic rats treated with all the plants combined showed the greatest reduction (59.2%). A. stenophylla and Z. officinale showed a glucose level reduction of 47.7%, A. stenophylla and C. limon (42.9%) whilst Z. officinale and C. limon (42.7%). The reductions in glucose levels were comparable to glibenclamide positive control which showed a 61% reduction. Conclusion: Combining the three plants (A. stenophylla, Z. officinale and C. limon) led to the greatest reduction in blood glucose levels of alloxan induced diabetic rats. The formulation demonstrates more potential in combinational herbal medicines therapy in diabetes management.

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“…A systematic review reported the analysis of randomized clinical trials (RCTs) conducted on type-2 diabetic human patients for examining the efficacy of ginger preparations against diabetes 17 . However, these studies ascribe the antidiabetic efficacy of ginger to the synergistic effects of phenolic phytochemicals mainly gingerols and their related dehydrated products, the shogaols and zingerone and it is not known that which bioactive compound of ginger is predominantly responsible for antidiabetic activity.…”

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confidence: 99%

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2016

IJPSR

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ABSTRACT:The effects of zingerone, on antidiabetic and hypolipidemic potential in streptozotocin-induced diabetic rats were investigated in the present study. Diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin (40 mg/kg bwt). Five days after STZ administration, diabetic rats received zingerone (10 mg/kg bwt) orally for 30 days. Metformin (Met) was used as reference drug. Zingerone treatment significantly reduced blood glucose level, Lipid profiles of serum, liver and kidney showed higher reduction in the levels of phospholipids, triglycerides and free fatty acids of zingerone treated diabetic rats than STZ-induced diabetic rats and Met-treated diabetic rats. In addition, zingerone treatment of STZ-rats was found to be effective in preserving the normal histological appearance of pancreatic islets, liver, and kidney, whereas the untreated diabetic rats exhibited pathological features. Thus, zingerone may have the potential in managing the effects of diabetic complications in human subjects.

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Efficacy of ginger for treating Type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials

Cited by 40 publications

References 16 publications

Effect of ginger on the blood glucose level of women with gestational diabetes mellitus (GDM) with impaired glucose tolerance test (GTT): a randomized double-blind placebo-controlled trial

Effect of ginger on the blood glucose level of women with gestational diabetes mellitus (GDM) with impaired glucose tolerance test (GTT): a randomized double-blind placebo-controlled trial

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