Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial

Guéniche, Audrey; Castiel-Higounenc, Isabelle

doi:10.1159/000450832

Cited by 13 publications

(6 citation statements)

References 35 publications

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“…There is tantalizing evidence with established longevitypromoting medications, such as rapamycin, resveratrol, metformin, and others ( Figure 1B), and we provided experimental evidence for this with tretinoin, genistein, glucosamine, chondroitin, and hyaluronic acid ( Figure 5). Consistent with this is that glucosamine and chondroitin stimulate collagen synthesis in vitro and ex vivo of elderly human skin in a clinical trial (Gueniche and Castiel-Higounenc, 2017;Lippiello, 2007), extracellular matrix component hyaluronic acid treatments stimulate collagen synthesis in human photo-aged skin (Wang et al, 2007), and in mice (Fan et al, 2019), and topical application of rapamycin restores collagen VII levels in a clinical trial (NCT03103893) (Chung et al, 2019). ECM homeostasis might remodel or prevent glycation and crosslinking of collagens (Ewald, 2019).…”

Section: Discussionmentioning

confidence: 80%

Youthful and age-related matreotypes predict drugs promoting longevity

Statzer

Jongsma

Liu

et al. 2021

Preprint

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The identification and validation of drugs that promote health during aging (‘geroprotectors’) is key to the retardation or prevention of chronic age-related diseases. Here we found that most of the established pro-longevity compounds shown to extend lifespan in model organisms also alter extracellular matrix gene expression (i.e., matrisome) in human cell lines. To harness this novel observation, we used age-stratified human transcriptomes to define the age-related matreotype, which represents the matrisome gene expression pattern associated with age. Using a ‘youthful’ matreotype, we screened in silico for geroprotective drug candidates. To validate drug candidates, we developed a novel tool using prolonged collagen expression as a non-invasive and in-vivo surrogate marker for C. elegans longevity. With this reporter, we were able to eliminate false positive drug candidates and determine the appropriate dose for extending the lifespan of C. elegans. We improved drug uptake for one of our predicted compounds, genistein, and reconciled previous contradictory reports of its effects on longevity. We identified and validated new compounds, tretinoin, chondroitin sulfate, and hyaluronic acid, for their ability to restore age-related decline of collagen homeostasis and increase lifespan. Thus, our innovative drug screening approach - employing extracellular matrix homeostasis - facilitates the discovery of pharmacological interventions promoting healthy aging.HighlightsMany geroprotective drugs alter extracellular matrix gene expressionDefined young and old human matreotype signatures can identify novel potential geroprotective compoundsProlonged collagen homeostasis as a surrogate marker for longevity

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Section: Discussionmentioning

confidence: 80%

Youthful and age-related matreotypes predict drugs promoting longevity

Statzer

Jongsma

Liu

et al. 2021

Preprint

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“…Fucose is the most popular hexose in the food industry (Shintani 2019). This monosaccharide is a component of sucrose and is highly sweet, leading to applications in the food and beverage industries with health bene ts due to low glycemic response (Gueniche and Castiel-Higounenc 2017). Our data showed that rice grains contain fucose with an average of 14 μg/mg (h b 2 = 0.97).…”

Section: Discussionmentioning

confidence: 73%

Rice (Oryza Sativa L.) Whole Grain Genome-Wide Association Study for Neutral Sugar Content

Panahabadi¹,

McKee²,

Ahmadikhah³

et al. 2021

Preprint

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Background Cell wall matrix polysaccharides are structurally complex and diverse, but our knowledge about their synthesis is limited. The building blocks (monosaccharides) of these polysaccharides have critical role in defining the number and the ultrastructure (size) of rice grains, and therefore would have great influence on seed vigor, yield and quality. Genome-wide association study (GWAS) is a method of choice for fine mapping of QTLs involved in defining plant cell wall structure and modifications. The monosaccharides that contribute to major cell wall matrix polysaccharides in whole grains of 197 rice accessions were quantified using acid hydrolysis and high-performance anion-exchange chromatography with pulsed amperometric detection. A GWAS of calculated monosaccharide content in rice whole grain (RWG) was carried out using 33,812 single-nucleotide polymorphisms (SNPs) to identify corresponding markers in 200 kbp flanking regions.Results In total, 49 significant SNPs contained in 19 genomic regions (QTLs) on eight chromosomes of rice were determined to be associated with monosaccharides content. The candidate genes in QTL regions included the following: arabinose content was associated with α-N-arabinofuranosidase, pectinesterase inhibitor, a glycoside hydrolase (GH) from family 16 (GH16 enzyme); xylose content was associated with ethylene-responsive element-binding protein and a pyruvate kinase; mannose content was associated with a MYB family transcription factor and S-domain receptor-like protein kinase; galactose content was associated with a glycocyltransferase (GT) from family 8 (GT8 enzyme), GRAS family transcription factor, glutathione S-transferase, GH16 and GH17 enzymes; fucose content was associated with a GH16 enzyme, lysine-rich arabinogalactan protein 19 and a receptor protein kinase; and finally rhamnose content was associated with OsFBX41, pectinesterase, COBRA-like protein, and OsSAUR13 (Auxin-responsive SAUR).Conclusion The results of this study should improve our understanding of the genetic basis of the factors that might be involved in the biosynthesis and turnover of major matrix polysaccharides present in RWG. Several QTLs were identified on different chromosomes, all are reported for first. Further, our data provide insight that will be useful in the design of future breeding programs, allowing breeders to use available genetic resources more effectively in meeting global food demand and supply.

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“…Again, the result was that the skin reaches biological maturity at an early age (15 -20 years) at which point it then starts to age [9]. Recent studies support the idea that collagen plays a role in the aging of the skin [10][11][12]. In addition to the work on the mechanical properties of the skin, investigations were also carried out in the past on the forces which were required to penetrate the skin and other materials with differently shaped objects.…”

Section: Discussionmentioning

confidence: 99%