Efficacy of Guar Gum in Preventing the Dumping Syndrome

Harju, E; Larmi, T. K. I.

doi:10.1177/0148607183007005470

Cited by 33 publications

(23 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Much of the work relating to the slowing of gastric emptying by guar gum and pectin used hypertonic liquid test meals (41,47,48) and the results may not be relevant to the emptying of solid meals of dry matter (49,50). Harju et al (51,52) have used pectin and guar gum to relieve symptoms of patients with dumping syndrome. In the latter study, prolongation of the gastric emptying time for solids was noted with guar (52).…”

Section: Physiologic Effects Of Fibermentioning

confidence: 99%

Dietary Fiber in Management of Diabetes

1988

View full text Add to dashboard Cite

Current evidence suggests that high-fiber diets, especially of the soluble variety, and soluble fiber supplements may offer some improvement in carbohydrate metabolism, lower total cholesterol and low-density lipoprotein (LDL) cholesterol, and have other beneficial effects in patients with non-insulindependent diabetes mellitus (NIDDM). Diets enriched with wheat bran and guar gum induce 10-20% reductions in serum cholesterol and LDL in both normoand hypercholesterolemic subjects and have the ability to blunt the hypertriglyceridemic effects of diets high in carbohydrate and low in fiber. In insulin-dependent diabetes mellitus (IDDM) the situation is less clear, but a decrement of the circadian glucose profile has been shown. Americans, in general, consume too little fiber. With the need to restrict fat and reduce protein, an increase in carbohydrates is mandatory. A practical goal would be to establish the present level of fiber intake (15-30 g/day) and to gradually increase it. An intake of up to 40 g of fiber per day or 25 g/1000 kcal of food intake appears beneficial; in many individuals on weight-reducing diets higher levels may be unacceptable because of gastrointestinal side effects. The level of maximum benefit has not been determined. Fiber supplementation appears beneficial only if given with a diet comprising approximately half of the calories as carbohydrate. Foods should be selected with moderate to high amounts of dietary fiber from a wide variety of choices to include both soluble and insoluble types of fiber. Insufficient data are available on the long-term safety of high-fiber supplements. People at risk for deficiencies, such as postmenopausal women, the

show abstract

Section: Physiologic Effects Of Fibermentioning

confidence: 99%

Dietary Fiber in Management of Diabetes

1988

View full text Add to dashboard Cite

show abstract

“…Such a reduction was found when guar gum was given to patients following gastric resection, to obese patients and to duodenal ulcer patients [6,[15][16][17], This supposition is supported by the findings in patients experiencing troublesome symptoms after proximal se lective vagotomy that the early phase of gastric emptying and the related increase in blood glucose concentration and decrease in plasma volume were markedly greater after 150 ml of a 50% glucose solution than in patients not showing symptoms [11]. However, there are patients with dumping syndrome with an early postprandial hy perglycemia, but there are also patients with a similar hyperglycemia without any symptoms [19].…”

Section: Discussionmentioning

confidence: 99%

Reduction of Postprandial Hyperglycemia by Guar Gum in Symptomatic Patients 5–10 Years following Proximal Selective Vagotomy

Harju¹,

Mäkelä²

1987

Dig Surg

Self Cite

View full text Add to dashboard Cite

The effects of guar gum on postprandial blood glucose concentrations in patients with postprandial symptoms (3 had dumping) 5–10 years after proximal selective vagotomy were studied. Eight subjects ingested 150 ml of a 50% glucose solution containing 5 g of guar gum and 7 subjects ingested 150 ml of a 50% glucose solution containing 5 g of wheat flour as placebo. Fifteen asymptomatic patients served as the control group. The results showed that guar gum decreased the postprandial rise and also slowed down the reversion of blood glucose concentrations to fasting levels. Changes of postprandial blood glucose concentration are one of the indicators of the unknown mechanism of the postprandial symptoms in patients after proximal selective vagotomy.

show abstract

“…The reduction in postprandial hyperglycemia is a result of decreased rates of digestion and absorption associated with the in creased meal viscosity. The study reported here shows that the effect of guar gum in reducing postprandial hyperglycemia in patients with intact stomachs [1][2][3] remains evident when the stomach has been completely removed, with food proceeding directly from the esoph agus to the lumen of the small intestine. Thus a reduc tion in gastric emptying rate, as described earlier [4][5][6], can not be the only explanation for the effect of guar gum in decreasing the postprandial hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

“…Hypergly cemia per se may not be the cause of the symptoms. However, it has been shown that dumping symptoms are associated with abnormal postprandial changes of blood glucose concentration, e.g., after proximal selective va-gotomy [9], and can be reduced in some patients by guar gum [3,10]. The postprandial symptoms after total gas trectomy are partly also nondumping ones.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that guar gum, a viscous dietary fiber, decreases postprandial hyperglycemia in healthy subjects and in various groups of patients [1][2][3]. The main reason for this decrease is believed to be a reduc tion in the gastric emptying rate through an increase in the viscosity of stomach contents, but decreases in the intestinal absorption of glucose may also occur [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Meal Viscosity on Postprandial Hyperglycemia in Patients Who Have Undergone Total Gastrectomy

Harju¹,

Nordback²

1987

Dig Surg

Self Cite

View full text Add to dashboard Cite

Blood glucose concentrations were measured two times in the same 7 patients who had undergone total gastrectomy 0, 20, 50, 80 and 120 min after two glucose meals (50 g of glucose and 100 ml of water), which on a double-blind basis contained 5 g of guar gum and 5 g of wheat flour in random order. The mean blood glucose concentration was significantly (p < 0.01–0.001) lower 20, 80 and 120 min after the meal containing guar gum than after the meal containing wheat flour. All patients except two (one 50 min and the other 80 and 120 min postprandially) had lower blood glucose concentrations after the meals containing guar gum than after the meals containing wheat flour. Three of four patients who used 5 g guar gum three times daily in their meals felt it benefical in preventing dumping-like symptoms. One got disturbing meteorism. It was concluded that guar gum decreased glucose absorption and prevented postprandial hyperglycemia in these total gastrectomy patients. Guar gum may facilitate the planning of diets for such patients.

show abstract

Efficacy of Guar Gum in Preventing the Dumping Syndrome

Cited by 33 publications

References 8 publications

Dietary Fiber in Management of Diabetes

Dietary Fiber in Management of Diabetes

Reduction of Postprandial Hyperglycemia by Guar Gum in Symptomatic Patients 5–10 Years following Proximal Selective Vagotomy

Effect of Meal Viscosity on Postprandial Hyperglycemia in Patients Who Have Undergone Total Gastrectomy

Contact Info

Product

Resources

About