Efficacy of Haemocoagulase as a Topical Haemostatic Agent after Minor Oral Surgical Procedures—A Prospective Study

Majumder, Kaberi; nbsp, S Syed Naser; Rao, Jiaming; Gehlot, Neelima; Arya, Varun; Siwach, Vijay

doi:10.4236/ijcm.2014.514117

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…Haemocoagulase has been extensively studied in dental surgeries. Majumder et al. (2014) evaluated the efficacy of topical hemocoagulase on 50 surgical sites in 25 patients who underwent simple dental extractions.…”

Section: Discussionmentioning

confidence: 99%

A comparative study between haemocoagulase and adrenaline in type 1 tympanoplasty

et al. 2019

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Introduction Haemostasis is a critical component of ear surgeries, which can be achieved by topical methods including simple manual pressure with gauze or cotton balls soaked with adrenaline, administration of haemostatic agents or vasoconstrictive materials. Objective To compare efficacy of haemocoagulase and adrenaline in attaining middle ear haemostasis in type - 1 tympanoplasty with or without cortical mastoidectomy. To study the effect of haemocoagulase in middle ear. Materials and method This is a prospective comparative study conducted in a tertiary care hospital from January 2013 to June 2014. Patients undergoing type 1 tympanoplasty with or without cortical mastoidectomy were divided into two groups. In group A (50 cases), cotton balls soaked in 2 ml Haemocoagulase was used and in group B (50 cases) cotton balls soaked in 2 ml Adrenaline (1:1000 dilution) was used for middle ear haemostasis. The efficacy of haemocoagulase and adrenaline was compared. Results The mean number of cotton balls used in haemocoagulase group in cases with congested middle ear mucosa was more than those used in the adrenaline group. Duration of surgery was more in haemocoagulase group (65 min) with congested mucosa, compared to adrenaline group (50 min). The mean blood pressure was significantly higher in adrenaline group compared to haemocoagulase group. Postoperative hearing improvement in both groups showed no significant difference with p value 0.694. Conclusions Adrenaline is a better middle ear haemostatic than haemocoagulase. However, haemocoagulase can safely be used in patients with hypertension.

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Section: Discussionmentioning

confidence: 99%

A comparative study between haemocoagulase and adrenaline in type 1 tympanoplasty

et al. 2019

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“…Patients in Group 2 were in the control group; ETIK COLLAGENE cylinders were not immediately placed after tooth extraction, it was delayed of 8 min. Based on recent publications, the maximum hemostasis time values range from 3 min to 7 min 20 s (5,(11)(12)(13)(14)(15)(16). Thus, to avoid bias, the bleeding time was evaluated over a period of 8 min in this clinical study before suturing the surgical site.…”

Section: Methodsmentioning

confidence: 99%

Application of a topical collagen agent after tooth extraction to control hemostasis should be immediate and not delayed: a comparative randomized trial

Protin,

Cameli,

Sérandour

et al. 2023

J Oral Med Oral Surg

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Objective: The main objective was to demonstrate that the delay of placement of a collagen-based hemostatic cylindrical dressing, here ETIK COLLAGENE, affects postoperative bleeding. Other objectives were to evaluate the safety of this medical device. Material and methods: 38 patients under antithrombotic treatment and consulting for tooth extraction were included. The antithrombotic treatment was maintained. Patients were randomized: In group 1: the hemostatic dressing ETIK COLLAGENE was applied immediately after the tooth extraction and curettage; the surgeon assessed the presence of bleeding (Yes/No) every 30 s up to a total time of 8 min, then he sutured. In group 2: the bleeding was assessed every 30 s up to a total time of 8 min immediately after the tooth extraction and curettage, then the surgeon placed ETIK COLLAGENE before suturing. Seven days later, patients were asked about the occurrence of bleedings and adverse events. Results: The mean bleeding time after tooth extraction was of 1:13 ± 0:49 (min: sec) and 3:39 ± 3:06 respectively in the group 1 and in the group 2; the difference between groups is 2:26 (95% CI [0:52 – 4:01]) in favor to the group 1 (p = 0.0144). There were significantly more adverse effects in group 2. Conclusions: The delay in placement of ETIK COLLAGENE after extraction has an impact on bleeding time and postoperative adverse events: these parameters are reduced in a statistically significant way when the placement is performed immediately after the end of the curettage rather than after an 8 min delay.

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“…9 Bleeding at the surgical site is very disturbing both for the patient and the surgeon. There are several conventional haemostatic techniques to minimize blood loss.…”

Section: Discussionmentioning

confidence: 99%

Role of local instillation of one percent feracrylum and haemocogulase on wound healing

Singh¹,

Dhruv²,

Patle³

et al. 2016

Int J Res Med Sci

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Background: The introduction of increasingly complex and major surgical procedures during the last 50 years has inevitably been accompanied by greater problems in wound healing. Fortunately, modern surgery is relatively safe, certainly by comparison with situation 50 years ago, but it cannot be said that it is totally devoid of risks or complications, and problems of wound healing are encountered in every surgical specialty. Indeed, in various ways these complication account for a large part of morbidity and mortality of surgical treatment.The present study has been carried out to evaluate role of local instillation of 1% feracrylum and haemocoagulase on wound healing. Methods: The present study was carried out in 100 patients in the Department of General Surgery, S.S. Medical College and associated G.M. Hospital and Sanjay Gandhi Memorial Hospital, Rewa (M.P.), India. The material for the study comprised of randomly selected 100 patients. A thorough clinical examination was done to assess general condition of patients and systemic disorder. Local examination was done to make a surgical diagnosis and associated problem. In case of surgical emergency, on arrival of patient clinical examination was immediately started and history asked during resuscitation of the patient. All relevant procedures were performed before surgery. Appropriate surgical procedures were performed. Suitable local haemostatic was applied. The wound inspected on 3rd, 7th and 14th day of presence of swelling, tenderness, colour change, discharge, scar tissue and changes were recorded. Results: Most of the patients were between 21-30 years and 50 and above. The youngest being 3 years and the eldest being 75 years old. Majority of patients were operated for Perforation Peritonitis (28%) and Hernia (26%). Next common group was Intestinal Obstruction (9%) and Cholecystectomy (7%). Out of 100 cases operated 60 were as planned and rests were as emergency cases. 1% Feracrylum and Haemocoagulase was used in equal number of cases. In 24 cases 1% Feracrylum was instilled subcutaneously in 10 cases instilled at intermuscular level and in 16 cases instilled at both level. In 23 cases Haemocogulase was instilled subcutaneously in 14 cases instilled at intermuscular level and in 13 cases instilled at both level. All cases Skin Wound was closed in Interrupted fashion. Conclusions: Good surgical technique plays key role in post-operative wound healing. The essential of good surgical technique include gentle handling of tissues, meticulous haemostasis, and prevention of dead space in the wound and avoidance of tissue necrosis resulting from excessive use of diathermy or strangulation of tissues by Ligatures. 1% Feracrylum and Haemocoagulase are helpful in decreasing local infection rate by decreasing post-operative capillary oozing.

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Efficacy of Haemocoagulase as a Topical Haemostatic Agent after Minor Oral Surgical Procedures—A Prospective Study

Cited by 9 publications

References 12 publications

A comparative study between haemocoagulase and adrenaline in type 1 tympanoplasty

A comparative study between haemocoagulase and adrenaline in type 1 tympanoplasty

Application of a topical collagen agent after tooth extraction to control hemostasis should be immediate and not delayed: a comparative randomized trial

Role of local instillation of one percent feracrylum and haemocogulase on wound healing

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