Efficacy of Handmade Antibiotic Pmma Beads in Treatment of Chronic Osteomyelitis

Abstract

BACKGROUNDThe term osteomyelitis literally implies inflammation of bone and its bone marrow. The infection involves the marrow space, the Haversian system, and the subperiosteal space. The bone is involved secondarily. (1) Chronic osteomyelitis generally cannot be eradicated without surgery, that is sequestrectomy and resection of scarred and infected bone and soft tissue. The hall mark of osteomyelitis is infected dead bone with in a compromised soft tissue envelope. This avascular envelope of scar tissue leaves systemic antibiotic essentially ineffective. Antibiotic impregnated bone cement beads, specifically designed to combat infection localised to bone and soft tissue, have beads, developed to counter these challenges.