Efficacy of Helicobacter pylori eradication in uninvestigated chronic dyspeptic staff members of a large factory: a prospective, long-term, follow-up, workplace outcome study

Madisch, Ahmed; Hotz, J; Grabowski, Gabriele; Guth, Angelika; Malfertheiner, Peter; Plein, K.; Schneider, Berthold

doi:10.1097/00042737-200201000-00011

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Madisch et al 38 investigated the outcome of H. pylori eradication in staff members with uninvestigated chronic dyspepsia in a large factory in a prospective, open-label, controlled, workplace outcome study after 1 year of follow-up of dyspepsia, and quality of life. H. pylori status was assessed using the 13 C-urea breath test in 267 individuals with dyspepsia.…”

Section: Prospective Studies (Not Rcts)mentioning

confidence: 99%

Helicobacter Pylori “Test-and-Treat” Strategy for Management of Dyspepsia: A Comprehensive Review

Gisbert

Calvet

2013

Clinical and Translational Gastroenterology

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OBJECTIVES:Deciding on whether the Helicobacter pylori test-and-treat strategy is an appropriate diagnostic–therapeutic approach for patients with dyspepsia invites a series of questions. The aim present article addresses the test-and-treat strategy and attempts to provide practical conclusions for the clinician who diagnoses and treats patients with dyspepsia.METHODS:Bibliographical searches were performed in MEDLINE using the keywords Helicobacter pylori, test-and-treat, and dyspepsia. We focused mainly on data from randomized controlled trials (RCTs), systematic reviews, meta-analyses, cost-effectiveness analyses, and decision analyses.RESULTS:Several prospective studies and decision analyses support the use of the test-and-treat strategy, although we must be cautious when extrapolating the results from one geographical area to another. Many factors determine whether this strategy is appropriate in each particular area. The test-and-treat strategy will cure most cases of underlying peptic ulcer disease, prevent most potential cases of gastroduodenal disease, and yield symptomatic benefit in a minority of patients with functional dyspepsia. Future studies should be able to stratify dyspeptic patients according to their likelihood of improving after treatment of infection by H. pylori.CONCLUSIONS:The test-and-treat strategy will cure most cases of underlying peptic ulcer disease and prevent most potential cases of gastroduodenal disease. In addition, a minority of infected patients with functional dyspepsia will gain symptomatic benefit. Several prospective studies and decision analyses support the use of the test-and-treat strategy. The test-and-treat strategy is being reinforced by the accumulating data that support the increasingly accepted idea that “the only good H. pylori is a dead H. pylori”.

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Section: Prospective Studies (Not Rcts)mentioning

confidence: 99%

Helicobacter Pylori “Test-and-Treat” Strategy for Management of Dyspepsia: A Comprehensive Review

Gisbert

Calvet

2013

Clinical and Translational Gastroenterology

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“…Madisch et al studied the outcome of Hp eradication in 267 factory workers from Germany who reported uninvestigated chronic dyspepsia ( Madisch et al, 2002 ). They assessed Hp infection status at baseline using the 13C-UBT, and positive workers (N = 111, 41.6%) were offered eradication therapy.…”

Section: Screening Working Populations For Helicobacter Pylorimentioning

confidence: 99%

The role of the occupational physician in controlling gastric cancer attributable to Helicobacter pylori infection: A review

Collatuzzo

Fiorini

Vaira

et al. 2021

Preventive Medicine Reports

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Treatment of functional dyspepsia

Feinle‐Bisset

Andrews

2003

Curr Treat Options Gastro

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Because there is currently no universally effective treatment for functional dyspepsia, a stepwise approach is useful. The initial steps should include 1) making a firm clinical diagnosis and providing the patient with appropriate information and reassurance; 2) ascertaining the reason for referral/consultation, as this determines what the patient will regard as a satisfactory outcome; 3) informing the patient that there is no universally effective drug treatment; and 4) giving dietary and general lifestyle advice, such as ingestion of smaller, more frequent meals, a low-fat diet, avoidance of certain foods that may exacerbate symptoms, limiting coffee and alcohol intake, smoking cessation, and stress management techniques. If the initial approach does not provide a satisfactory outcome, the following approaches may be helpful. Psychologic treatment approaches, such as hypnotherapy and/or antidepressants, have shown very encouraging results in recent studies and deserve active consideration. In patients with uninvestigated dyspepsia, the "test and treat" strategy for Helicobacter pylori is a cost-effective approach. Prokinetics are of possible benefit in subjects with delayed gastric emptying; however, the relationship between improvement of gastric emptying and symptom alleviation is weak. Furthermore, it needs to be recognized that treatments directed at acid suppression are generally of little sustained benefit, and that there is ongoing controversy as to whether H. pylori eradication is of direct benefit.

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Efficacy of Helicobacter pylori eradication in uninvestigated chronic dyspeptic staff members of a large factory: a prospective, long-term, follow-up, workplace outcome study

Abstract: These data suggest that an H. pylori test-and-treat strategy in occupational medicine is effective for improving uninvestigated dyspepsia and quality of life and it may reduce dyspepsia related health care costs at a level of occupational medicine.

Cited by 5 publications

References 34 publications

Helicobacter Pylori “Test-and-Treat” Strategy for Management of Dyspepsia: A Comprehensive Review

Helicobacter Pylori “Test-and-Treat” Strategy for Management of Dyspepsia: A Comprehensive Review

The role of the occupational physician in controlling gastric cancer attributable to Helicobacter pylori infection: A review

Treatment of functional dyspepsia

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