Efficacy of hemoadsorption using HA330-II perfusion column in secondary HLH patients: two cases report and literature review.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a severe and potentially lethal disorder characterized by overwhelming immune activation and inflammation. Several blood purification methods have been reported to be successfully practiced as adjuvant therapy for hypercytokinamia complicated with HLH. We firstly reported two cases of secondary HLH children received hemoadsorption therapy with HA330-II perfusion cartridge combined with CVVHDF. The marked decrease in IL-6 plasma levels and stabilization of organ function were observed after treatment, which proved the efficiency of HA330-II perfusion column. Keywords: hemoadsorption, blood purification, Hemophagocytic lymphohistiocytosis, pediatric