Efficacy of heparinoid moisturizer as a prophylactic agent for radiation dermatitis following radiotherapy after breast-conserving surgery: a randomized controlled trial

Sekiguchi, Kenji; Akahane, Koshi; Ogita, Mami; Haga, C.; Ito, Ryoko; Arai, Satoru; Ishida, Yasushi; Tsukada, Yoichiro; Kawamori, Jiro

doi:10.1093/jjco/hyy045

Cited by 25 publications

(29 citation statements)

References 31 publications

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“…The stratum corneum functions as a barrier that prevents water loss and protects the body from external stressors [ 21 ]. Ionizing radiation impairs the skin barrier functions of the stratum corneum, resulting in increased transepidermal water loss and decreased water content [ 22 ]. Consistent with our findings, previous investigations have shown that the water content in irradiated skin continuously decreases as radiotherapy sessions proceed over time.…”

Section: Discussionmentioning

confidence: 99%

Impact of Breast Reconstruction on Biophysical Parameters of Mammary Skin in Patients Receiving Postmastectomy Radiotherapy for Breast Cancer

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Impact of Breast Reconstruction on Biophysical Parameters of Mammary Skin in Patients Receiving Postmastectomy Radiotherapy for Breast Cancer

et al. 2021

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“…[25–27] In our previous report, heparinoid moisturizer maintained stratum corneum WC and reduced skin desquamation and dryness. [14, 15] The skin itself is not the primary target of RT in breast-conserving therapy. [27] However, the skin exposure to significant doses is inevitable during RT, thereby causing damage to the sweat and sebaceous glands.…”

Section: Discussionmentioning

confidence: 99%

“…The primary endpoint of the WC of stratum corneum and the other secondary outcomes of signs and symptoms associated with acute radiation dermatitis were previously reported. [14, 15] In this article, we report the time-course of sebum.…”

Section: Methodsmentioning

confidence: 99%

“…We previously reported the time-course of WC of stratum corneum after WBRT and showed that heparinoid moisturizer effectively increased the WC of stratum corneum and the preventive application reduced skin desquamation and dryness. [14, 15] In the present article, we report the time-course of sebum content and the efficacy of heparinoid moisturizer.…”

Section: Introductionmentioning

confidence: 99%

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Damage to sebaceous gland and the efficacy of moisturizer after whole breast radiotherapy: a randomized controlled trial

et al. 2019

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BackgroundWe conducted a randomized trial to evaluate the efficacy of heparinoid moisturization for radiation dermatitis. We report the time-course of sebum content after whole breast radiotherapy (WBRT) and the efficacy of heparinoid moisturizer.MethodsPatients receiving adjuvant breast RT were randomly assigned into three groups; prophylaxis, post-WBRT and control groups. Patients used moisturizer on the irradiated breast from the beginning of RT in the prophylaxis group, 2 weeks post-RT in the post-WBRT group, and no moisturizer in the control group. Sebum content of the irradiated and non-irradiated breast was measured to assess sebaceous gland damage. Sebum composition was also analyzed.ResultsA total of 76 patients were analyzed; 30 in the post-WBRT group, 32 in the control group, 14 in the prophylaxis group. The sebum content in the irradiated breast significantly decreased after WBRT in the post-WBRT and control groups. The decrease was sustained in the control group. In the non-irradiated breast, sebum content also decreased after WBRT in the post-WBRT and control groups. After moisturizer application, sebum content by sebumeter returned to pre-RT level in the post-WBRT group, while the decrease was sustained in the control group. Sebum content measured by evaporative light scattering detector and sebumeter was similar in the control group, but the dissociation was observed after moisturizer application in the post-WBRT group. The proportion of wax esters decreased in the irradiated breast after WBRT.ConclusionsRadiotherapy significantly reduced sebum content in both irradiated and non-irradiated breast, indicating that RT caused quantifiably persistent sebaceous gland damage in irradiated sites and the surrounding tissue. Combined with the results from our previous study, heparinoid moisturizer treatment effectively prevents water loss by retaining oil contents on the skin surface.Trial registrationUMIN, UMIN000005532. Registered 1 April 2011.Electronic supplementary materialThe online version of this article (10.1186/s12885-019-5334-9) contains supplementary material, which is available to authorized users.

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“…Os sintomas podem aparecer durante ou mesmo após o término do tratamento podendo variar de um leve eritema (radiodermite grau I) até exulcerações importantes (radiodermite grau IV) que levam a interrupção do tratamento e incapacidades e limitações nos pacientes afetados. 4 O diagnóstico e tratamento adequado dessas complicações são extremamente importantes para que não haja uma diminuição das doses dos medicamentos e até mesmo interrupção do tratamento oncológico proposto que podem impactar de forma negativa nos resultados do tratamento e taxas de sobrevida dos pacientes. 5 Tendo em vista que o intuito principal dos produtos para cuidados da pele é promover um suporte exógeno para manter a barreira cutânea intacta, assim como preservar a hidratação da pele visando reduzir e aliviar os sintomas de xerose e consequentemente, prurido, infeções secundárias e reações de sensibilização, além de tornar a pele mais resistente aos efeitos da radiação, o objetivo do presente trabalho foi verificar a aceitabilidade cutânea em peles oncológicas dos produtos: Klaviê Creme, Klaviê Loção e Klaviê Sabonete Líquido por meio de observação da melhora na hidratação e redução da perda transepidérmica de água da pele em pacientes em tratamento oncológico (quimioterapia ou radioterapia).…”

Section: Introductionunclassified

Avaliação Clínica da Aceitabilidade Cutânea de Creme Hidratante, Loção Hidratante e Sabonete Líquido Corporal em Peles Oncológicas

Fabra¹,

Turke²,

Schoueri³

et al. 2018

Clin. Onc. Let.

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Financiamento: TheraSkin Farmaceutica ltda. Conflito de interesse: Os autores declaram que o estudo foi patrocinado pela TheraSkin Farmaceutica ltda.Este é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que o trabalho original seja corretamente citado.Objetivo: Verificar a aceitabilidade cutânea em peles oncológicas dos produtos: Klaviê Creme, Klaviê Loção e Klaviê Sabonete Líquido. Métodos: Estudo clínico, com inclusão de 40 participantes em tratamento oncológico para uso contínuo das substâncias a serem testadas, por não menos que 21 dias. A seleção foi realizada através de prontuários clínicos e banco de dados formado pelo Centro de Estudos Dermatológicos Kenji Toyoda, em parceria com a médica investigadora principal. Os participantes foram submetidos à avaliação dermatológica clínica e testou-se a hidratação cutânea e perda de água transdérmica por equipamento de técnica não invasiva (CORNEOMETER® e TEWAMETER® da fabricante Courage-Khazaka) para medição das características fisiológicas da pele. Resultados: As aferições do Corneometer® demonstram eficácia hidratante em 85% dos participantes, com aumento de 38% no nível de hidratação da pele. Além disso, dos participantes avaliados por meio do Tewameter ® , 65% reduziram a perda de água da pele em média 14%. Foram contabilizadas 06 perdas de seguimento e, apenas, 02 exclusões por evento adverso não grave não ligados ao produto, mas ao tratamento oncológico previamente estabelecido. Conclusão: Houve boa aceitabilidade cutânea dos produtos testados, tendo sido considerado aprovado para uso tópico desde que estritamente observadas as orientações de sua rotulagem no decorrer da aplicação, como orientado pelo fabricante. AbstractObjective: To verify the cutaneous acceptability in oncological skin of the products: Klaviê Cream, Klaviê Lotion and Klaviê Liquid Soap. Methods: Clinical study, including 40 participants in cancer treatment for continuous use of the substances to be tested, for no less than 21 days. The selection was made through clinical records and database formed by the Kenji Toyoda Dermatological Studies Center, in partnership with the principal investigator. The participants were submitted to clinical dermatological evaluation and skin hydration was tested by non-evasive technique (CORNEOMETER® and TEWAMETER® from manufacturer Courage -Khazaka) for the measurement of the physiological characteristics of the skin. Results: Corneometer® measurements demonstrate hydrating efficacy in 85% of the participants, with a 38% increase in the level of skin hydration. In addition, of the participants evaluated using Tewameter®, 65% reduced skin water loss by an average of 14%. There were 6 follow-up losses and only 2 exclusions per non-severe adverse event. Conclusion: There was good cutaneous acceptability of the tested products, having been considered approved for topical use provided strictly following of the guidelines of its label...

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Efficacy of heparinoid moisturizer as a prophylactic agent for radiation dermatitis following radiotherapy after breast-conserving surgery: a randomized controlled trial

Abstract: Preventive application of heparinoid moisturizer from the first day of WBRT significantly increased water content and helped to improve skin desquamation and dryness compared with no treatment.

Cited by 25 publications

References 31 publications

Impact of Breast Reconstruction on Biophysical Parameters of Mammary Skin in Patients Receiving Postmastectomy Radiotherapy for Breast Cancer

Impact of Breast Reconstruction on Biophysical Parameters of Mammary Skin in Patients Receiving Postmastectomy Radiotherapy for Breast Cancer

Damage to sebaceous gland and the efficacy of moisturizer after whole breast radiotherapy: a randomized controlled trial

Avaliação Clínica da Aceitabilidade Cutânea de Creme Hidratante, Loção Hidratante e Sabonete Líquido Corporal em Peles Oncológicas

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