Efficacy of hepatitis A vaccine in prevention of secondary hepatitis A infection: a randomised trial

Sagliocca, Luciano; Amoroso, P; Stroffolini, Tommaso; Adamo, B; Tosti, Maria Elena; Lettieri, Gennaro; Esposito, Ciro; Buonocore, Salvatore; Pierri, P; Mele, Alfonso

doi:10.1016/s0140-6736(98)08139-2

Cited by 163 publications

(56 citation statements)

References 16 publications

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“…A vacina tem sido utilizada com sucesso na profilaxia pós-exposição em controles de surtos e nos contatos domiciliares e de creches [53][54][55] ; deve ser aplicada o mais precocemente possível após o contato. O uso de imunoglobulina humana é eficaz nos casos de pós-exposição, quando aplicada até 2 semanas após o contato 53 .…”

Section: Hepatite Aunclassified

Vaccination in special situations

Succi¹,

Farhat²

2006

J Pediatr (Rio J)

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Objectives: To review the indications, contraindications and efficacy of vaccination in some special situations: immunosuppression, prematurity, pregnancy and post-exposure situations.Sources of data: Systematic review of articles published during the two last decades, found in MEDLINE, SciELO and Lilacs databases; guidelines of Programa Nacional de Imunizações (Brazilian National Immunization Program), 2001 to 2004, and of Programa Nacional de DST/AIDS (Brazilian National STD/AIDS Program), 2004. Abstracts published in national and international pediatric and infectious disease congress annals during the last five years were also consulted.Summary of the findings: Some special situations, such as immunosuppression, prematurity, pregnancy and exposure to infectious diseases increased the risk of diseases or adverse postvaccination events. In these situations, special vaccines or special vaccination schedules are indicated, or vaccines should be postponed or even forbidden. In general, toxoid or inactivated vaccines can be used, considering the possibility of insufficient immune response. For immunosuppressed patients, in accordance with the type of immunosuppression, live virus or bacterial vaccines should be avoided, because of the risk of vaccine agent spread. Immunization should include not only the patient, but his/her home and day-care contacts as well.Conclusions: Knowledge about the schedule indicated for each situation improves the chances of better vaccine protection and decreases the risk of adverse events. Immunosuppressed or immunodeficient patients whose post-vaccine antibody titers are not available should be considered susceptible when exposed to infectious disease, and all the available prophylactic measures should be implemented, even when the vaccination schedule is correct.J Pediatr (Rio J). 2006;82(3 Suppl):S91-100: Immunization, prematurity, immunosuppression, pregnancy. ResumoObjetivos: Revisar a indicação, contra-indicação e eficácia da vacinação em algumas situações especiais: imunossupressão, prematuridade, gestação e pós-exposição. Síntese dos dados: Algumas situações especiais, como imunossupressão, prematuridade, gestação e exposição às doenças infecciosas, colocam os indivíduos em maior risco de adoecer ou apresentar eventos adversos pós-vacinais. Essas situações requerem esquemas vacinais diferenciados, podem indicar adiamento da vacinação e mesmo contra-indicá-la. De modo geral, as vacinas inativadas, ou de toxóides, podem ser aplicadas, levando-se sempre em consideração a possibilidade de resposta imunogênica insuficiente. Para indivíduos imunossuprimidos, as vacinas de vírus e bactérias vivos devem ser evitadas devido ao risco de disseminação do agente vacinal. O cuidado na imunização deve incluir não só o paciente, mas seus contatos no domicílio, creche, etc.Conclusões: Esquemas adequados para cada uma dessas situações aumentam a possibilidade de obter melhor proteção vacinal e diminuem o risco de eventos adversos indesejáveis. Após exposição às doenças infecciosas, indi...

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Section: Hepatite Aunclassified

Vaccination in special situations

Succi¹,

Farhat²

2006

J Pediatr (Rio J)

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“…[53][54][55] It must be applied as soon as possible after contact. The use of human immunoglobulin is efficient in post-exposure…”

Section: Hepatitis Amentioning

confidence: 99%

Vacinação em situações especiais

Succi¹,

Farhat²

2006

J. Pediatr. (Rio J.)

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Objectives: To review the indications, contraindications and efficacy of vaccination in some special situations: immunosuppression, prematurity, pregnancy and post-exposure situations. Summary of the findings: Some special situations, such as immunosuppression, prematurity, pregnancy and exposure to infectious diseases increased the risk of diseases or adverse post-vaccination events. In these situations, special vaccines or special vaccination schedules are indicated, or vaccines should be postponed or even forbidden. In general, toxoid or inactivated vaccines can be used, considering the possibility of insufficient immune response. For immunosuppressed patients, in accordance with the type of immunosuppression, live virus or bacterial vaccines should be avoided, because of the risk of vaccine agent spread. Immunization should include not only the patient, but his/her home and day-care contacts as well.Conclusions: Knowledge about the schedule indicated for each situation improves the chances of better vaccine protection and decreases the risk of adverse events. Immunosuppressed or immunodeficient patients whose postvaccine antibody titers are not available should be considered susceptible when exposed to infectious disease, and all the available prophylactic measures should be implemented, even when the vaccination schedule is correct.

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“…El 40% de ellos se ha presentado en instituciones, principalmente colegios 6 . Cabe destacar que en noviembre de 2002 en Ministerio de Salud implementó el uso de vacuna anti hepatitis A para el control de brotes, con base en evidencia científica y experiencias internacionales [7][8][9] .…”

Section: Situación Epidemiológica Actualunclassified

Situación epidemiológica de hepatitis A en Chile

Aguilera

2003

Rev. chil. infectol.

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Efficacy of hepatitis A vaccine in prevention of secondary hepatitis A infection: a randomised trial

Cited by 163 publications

References 16 publications

Vaccination in special situations

Vaccination in special situations

Vacinação em situações especiais

Situación epidemiológica de hepatitis A en Chile

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