Efficacy of high-dose-rate interstitial brachytherapy in patients with oral tongue carcinoma

Institutional Experience of Interstitial Brachytherapy for Head and Neck Cancer with a Comparison of High- and Low Dose Rate Practice

“…Early detection and treatment of disease failure improves the overall disease control rates. The various HDR-IBT series report incidence of 0-29% and 0-8% for soft-tissue-and osteo-necrosis, respectively (Inoue et al, 2001;Kakimoto et al, 2003;Yamazaki et al, 2003;Nose et al, 2004;Guinot et al, 2010;Ghadjar et al, 2012).…”

“…A relevant finding from our HDR cohort illustrates that the usage of combination therapy with a lesser dose of IBT (12-18 Gy in 3-6 fractions; median=15 Gy/5 fractions) for T2 tumours of >3 cm size may have resulted in the poorer outcome. A better outcome has been observed when a higher dose of IBT is employed with less or no EBRT (Nag et al, 2001;Guinot et al, 2010). Early detection and treatment of disease failure improves the overall disease control rates.…”

“…Most experience with interstitial brachytherapy (IBT) for early stage HNC has been reported using the LDR technique (Mazeron et al, 2002). There have been recent reports of HDR brachytherapy employed as a therapeutic modality for HNC (Glatzel et al, 2002;Nose et al, 2004;Guinot et al, 2010;Bartochowska et al, 2012). However, there is considerable variation in the published series with respect to the HDR dose and fractionation schedules.…”

Clinical Investigations Interstitial HDR brachytherapy (HDR-BT) in early stage mobile tongue cancers in young patients – Gliwice experience

“…It was shown that in early stage tongue cancer both surgery with EBRT and EBRT with interstitial brachytherapy are effective at a similar level, with a local failure rate of 15-25% [6]. Interstitial brachytherapy is the most conformal technique which increases the dose to the target while sparing normal tissues [7, 11, 12] and it is recommended by the American Brachytherapy Society as a component of the treatment in head-and-neck tumours [15]. The role and effectiveness of LDR brachytherapy in tongue cancer is very well documented, but there are only a limited number of papers on HDR-BT [7, 11, 13, 15].…”

Use of megavoltage computed tomography with image registration for high–dose rate treatment planning of an oral tongue cancer using a custom oral mold applicator with embedded lead shielding

“…Although brachytherapy has been shown to be an effective modality for the treatment of oral tongue cancer (1,9,10), severe complications such as mandibular osteoradionecrosis can occur without careful planning or custom lead shielding (3,5,6,11). Current CT-based highedose rate (HDR) brachytherapy treatment planning systems can create sophisticated plans by varying the dwell times of the source and provide highly customized and optimized treatment plans.…”