Efficacy of High‐Throughput Leukocytapheresis for Rheumatoid Arthritis With a Reduced Response to Infliximab

Sakai, Yukinao; Sakai, Shunta; Otsuka, Tomoyuki; Ohno, Dai; Murasawa, Tsuneo; Munakata, Kazuo; Mizuno, Kyoichi

doi:10.1111/j.1744-9987.2009.00657.x

Cited by 11 publications

(12 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, changes in PD findings by LCAP correlated with changes in evaluator's global assessment and swollen joint count but not with those in CRP or ESR. The results of the present study are similar to those of previous findings (11,23,24) and showed that LCAP inhibits synovitis even in RA patients without decreases in CRP systemic inflammatory reaction.…”

Section: Discussionsupporting

confidence: 93%

“…Correlations between changes of PDUS findings and those of DAS28, CRP, and ESR by anti-TNF-α therapy have been reported (9,21). Among the components of the DAS or Simplified Disease Activity Index, LCAP is marked by decreases in tender joint count, swollen joint count, patient's global assessment, and evaluator's global assessment but by slight decreases in CRP and ESR (11,23,24). In the present study, changes in PD findings by LCAP correlated with changes in evaluator's global assessment and swollen joint count but not with those in CRP or ESR.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound Evaluation of the Effects of Leukocytapheresis on Rheumatoid Arthritis

Takeuchi

Maeda²,

Kimura

et al. 2013

Ther Apher Dial

View full text Add to dashboard Cite

Leukocytapheresis (LCAP) is effective in treating rheumatoid arthritis (RA). Ultrasound (US) examination of joints is useful for evaluating disease activity and therapeutic effects in RA, but the clinical assessment of LCAP therapy with US has been little reported. We investigated the usefulness of US for evaluating the effects of LCAP in patients with RA. US examination was performed in six patients (total of seven cases) who underwent LCAP. Twenty-eight joints (bilateral shoulders, elbows, wrists, 1st to 5th metacarpophalangeal joints, 1st to 5th proximal interphalangeal joints, and knee joints) were evaluated by a systematic multiplanar grey-scale and power Doppler (PD) examination. Disease activity of RA was evaluated using the 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR). Moderate or good responses to LCAP based on the DAS28-ESR were observed in four of the seven cases although C-reactive protein (CRP) and ESR did not decrease. LCAP significantly reduced the mean total PD score 17.3 ± 11.6 to 13.0 ± 10.5 (P = 0.0469). The total PD score decreased in six of the seven cases, and the number of joints with PD score ≥ 2 decreased in five of the seven cases. The rate of decrease in the number of joints with PD score ≥ 2 correlated strongly with the DAS28-ESR and its components, especially swollen joint counts and evaluator's global assessment, but not with the rate of decrease in CRP and ESR. US imaging of joints may be useful for evaluating the therapeutic effects of LCAP on RA compared to other inflammatory parameters.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Ultrasound Evaluation of the Effects of Leukocytapheresis on Rheumatoid Arthritis

Takeuchi

Maeda²,

Kimura

et al. 2013

Ther Apher Dial

View full text Add to dashboard Cite

show abstract

“…By cytapheresis, inflammatory cells (granulocytes, monocytes, or lymphocytes) or platelets are depleted from the peripheral blood. Cytapheresis has been successfully applied in rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease (7–9). In dermatology, patients with psoriasis and pyoderma gangrenosum have been successfully subjected to leukocytpheresis (10,11).…”

mentioning

confidence: 99%

Immunoadsorption in Dermatology

Meyersburg¹,

Schmidt

Kasperkiewicz³

et al. 2012

Ther Apher Dial

View full text Add to dashboard Cite

Immunoadsorption (IA) has been successfully used in a large variety of autoantibody-mediated disorders. In dermatology, IA is increasingly applied as adjuvant treatment for severe and/or refractory autoimmune bullous diseases. These disorders are characterized by autoantibodies against structural proteins of the skin and/or mucous membranes and include, among others, pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid. Autoimmune blistering diseases are associated with a high mortality (pemphigus) or morbidity (bullous pemphigoid) and in particular in pemphigus diseases, treatment is challenging.The pathogenetic role of autoantibodies in most of the immunobullous diseases has been clearly demonstrated, therefore, removal of these autoantibodies is a rational therapeutic approach. IA has been shown to effectively lower the serum autoantibodies and to lead to rapid clinical responses. Most recently, IA has been successfully applied in patients with severe atopic dermatitis and high total serum IgE levels. Here, the different treatment protocols, clinical efficacy, and adverse events are summarized.

show abstract

“…Leukapheresis has also been proposed as a therapy for some autoimmune diseases such as rheumatoid arthritis (Sakai et al, 2009). However, the long-term effect of such therapy is unknown.…”

Section: Discussionmentioning

confidence: 99%

Homeostasis of lymphocytes and monocytes in frequent blood donors

Ratts¹

2012

Front. Immun.

View full text Add to dashboard Cite

Age-associated decline of immune function is believed to be mainly due to alterations of immune cells. However, longitudinal changes of human immune cells with age have not yet been adequately addressed. To test the hypothesis that regeneration of lymphocytes and monocytes is robust throughout most of adult life until advanced age, we examined six leukapheresis donors (3 young and 3 middle-aged/old) who donated approximately 10% of their peripheral blood mononuclear cells (PBMC) every other month over 3–5 years. We found the number of both lymphocytes and monocytes were quite stable in the blood of all six donors. As expected, young donors had more T cell receptor excision circles (TRECs), CD31{}+ cells (CD4 only) and longer telomeres in T cells than did the middle-aged donors. Interestingly, more variation in TREC number, Vβ usages, and telomere lengths were observed in young donors during the 3–5 years course of donation whereas the middle-aged/old donors showed a rather striking stability in these measurements. This may reflect a more prominent role of thymic output in T cell regeneration in young than in middle-aged/old donors. Together, these findings provide an in vivo glimpse into the homeostasis of lymphocytes and monocytes in the blood at different ages, and support the notion that regeneration of lymphocytes and monocytes is robust throughout adult life up to the early 70s.

show abstract

Efficacy of High‐Throughput Leukocytapheresis for Rheumatoid Arthritis With a Reduced Response to Infliximab

Cited by 11 publications

References 19 publications

Ultrasound Evaluation of the Effects of Leukocytapheresis on Rheumatoid Arthritis

Ultrasound Evaluation of the Effects of Leukocytapheresis on Rheumatoid Arthritis

Immunoadsorption in Dermatology

Homeostasis of lymphocytes and monocytes in frequent blood donors

Contact Info

Product

Resources

About