Efficacy of House Dust Mite Sublingual Immunotherapy in Patients with Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Reply to “House dust mite liquid SLIT effective in atopic dermatitis, even with suboptimal dosing”

“…We have recently performed measurements of IgE and IgG 4 antibodies to mite allergens Der p 1, Der p 2, and Der p 10 by ImmunoCAP on the 66 patients who completed our SLIT trial. 2 The results showed a significant decrease in levels of IgE to Der p 2 after 18 months of treatment as compared with baseline, in the group treated with HDM SLIT (Table I), suggesting an immunologic effect underlying the clinical benefits observed in our study. No significant changes in IgG 4 antibodies were observed associated with SLIT.…”

“…We appreciated the comments of Larenas-Linnemann and Pech 1 on our recent article. 2 Their concerns regarding sublingual immunotherapy (SLIT) schedule, optimal dose, and composition of allergenic extracts are fundamental to our specialty. However, Larenas-Linnemann and Pech's analysis was based on studies conducted in patients with rhinitis and/or asthma, or on experimental data from a mouse model of allergic airway inflammation on the effects of SLIT with grass pollen extract.…”

“…However, Larenas-Linnemann and Pech's analysis was based on studies conducted in patients with rhinitis and/or asthma, or on experimental data from a mouse model of allergic airway inflammation on the effects of SLIT with grass pollen extract. 2 So, we hope to persuade the readers that house dust mite (HDM) SLIT in patients with atopic dermatitis (AD) may be different and unique. Because few well-designed published studies were available, we were concerned about safety as well as efficacy of HDM SLIT in our patients with AD, aiming at a treatment modality that would be safe for unsupervised administration at home.…”

Good clinical practice recommendations in allergen immunotherapy: Position paper of the Brazilian Association of Allergy and Immunology – ASBAI

“…17 Several studies have pointed out that AIT may also contribute to the treatment of other allergic diseases, such as atopic dermatitis. 18 , 19 , 20 , 21 Recently, a double-blind placebo-controlled clinical trial conducted in Brazil demonstrated the efficacy of SLIT in the treatment of patients with atopic dermatitis sensitized to house dust mites. 21 Currently in Brazil, SLIT is available only in the form of drops.…”

“… 18 , 19 , 20 , 21 Recently, a double-blind placebo-controlled clinical trial conducted in Brazil demonstrated the efficacy of SLIT in the treatment of patients with atopic dermatitis sensitized to house dust mites. 21 Currently in Brazil, SLIT is available only in the form of drops. SLIT in drops has been used in Europe since the 1980s, when the first clinical trials were conducted.…”