Efficacy of hydrotherapy, spa therapy, and balneotherapy for psoriasis and atopic dermatitis: a systematic review

Jazani, Arezoo Moini; Ayati, Mohammad Hossein; Nadiri, Ata Allah; Azgomi, Ramin Nasimi Doost

doi:10.1111/ijd.16080

Cited by 13 publications

(8 citation statements)

References 70 publications

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“…In 2018, Fioravanti et al demonstrated the efficacy of BT in patients with fibromyalgia by using the thermal water of Vetriolo (Trento, Italy), which descend from the Vetriolo spring in the thick of the fir woods at an altitude of 1500 m. Indeed, Vetriolo’s water is a highly mineralized (fixed residue at 180 °C 1702 mg/L) strongly acidic (pH 5.7) sulfate (1100 mg/L) water that is rich in calcium (111.0 mg/L), magnesium (65.5 mg/L), and iron (315 mg/L) [ 70 ]. Several studies have indicated the efficacy of BT with natural mineral water for psoriasis and atopic dermatitis [ 71 ].…”

Section: Beneficial Effects Of Nitrodi’s Water: Ongoing Datamentioning

confidence: 99%

The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications

Mormile,

Tuccillo,

Della Casa

et al. 2023

IJMS

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Natural products (water, plants, and minerals) have been studied for diverse applications in health and disease. Since there has been a growing interest in the introduction of thermal water as a clinical complementary approach in the treatment of low-grade inflammation and stress-related conditions, this review focuses on the oldest spa in the world: Nitrodi’s spring. Substantial studies in the 1960s showed that both the internal and external use of Nitrodi’s water yielded several benefits in physiological processes and in treating certain disorders, mainly allergic and autoimmune inflammatory conditions. More recently, a novel interest in Nitrodi’s water has prompted researchers to further explore the effects of this water and shed light on the molecular mechanisms sustaining its therapeutic efficacy. In different epithelial cell models, Nitrodi’s water had strong promotional effects on proliferation, cell migration, cell viability, and fibroblast to myofibroblast transition, all of which essential for wound healing and tissue remodeling. Moreover, Nitrodi’s water exhibited anti-oxidant and anti-inflammatory properties through the inhibition of ROS production and protein S-nitrosylation. Here, we have collected the clinical and basic data on Nitrodi’s water and reviewed articles that have discussed its use as a potential treatment for several inflammatory and autoimmune diseases and age-related skin deterioration.

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Section: Beneficial Effects Of Nitrodi’s Water: Ongoing Datamentioning

confidence: 99%

The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications

Mormile,

Tuccillo,

Della Casa

et al. 2023

IJMS

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show abstract

“…Besides, a recent narrative review evidenced a great positive effect of balneotherapy on psoriasis and atopic dermatitis and other dermatological conditions and diseases such as pruritus, prurigo, lichen ruber planus, acne vulgaris, and seborrheic dermatitis (Cacciapuoti et al 2020 ). In addition, a recent systematic review demonstrated the potential positive effects of balneotherapy on dermatological diseases, but it was focalized on specific conditions such as psoriasis and atopic dermatitis (Moini Jazani et al 2023 ). In our knowledge, no recent systematic review summarizes the scientific evidence on balneotherapy and all the known dermatological diseases.…”

Section: Introductionmentioning

confidence: 99%

Balneotherapy using thermal mineral water baths and dermatological diseases: a systematic review

Protano,

Vitali,

De Giorgi

et al. 2024

Int J Biometeorol

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Balneotherapy includes practices and methods using medically and legally recognized mineral-medicinal waters, muds and natural gases from natural springs for therapeutic purposes. One of the most widely used method in balneotherapy is bathing with thermal mineral water. In the course of the years, scientific community has produced an increasing number of evidences that this practice is an effective method for treating signs and symptoms of several pathologies such as rheumatic, cardiovascular and dermatological diseases. This systematic review is aimed at evaluating the effect of balneotherapy with thermal water baths as a treatment to manage signs and symptoms of patients affected by all types of dermatological diseases. The systematic review was conducted according to the PRISMA Statement, and its protocol was registered on PROSPERO platform (CRD42022295913). The research was performed on the databases Pubmed, Scopus, Web of Science and Cochrane. We included clinical trials evaluating the effects of balneotherapy using thermal mineral water baths for managing dermatological diseases in humans, published in English and Italian language. Eight studies were included, seven of them enrolled adults affected by psoriasis and one studied atopic dermatitis patients. The common result of all the articles included was a clear improvement of signs and symptoms of psoriasis and eczematous diseases after use of thermal mineral water baths. These effects seem to be strictly related to physical and chemical properties of thermal water used for balneotherapy. However, studies in this field are still limited to support robust evidence of the effectiveness of balneotherapy using thermal mineral water baths and often their quality is low. Thus, new clinical studies need to be carried out, using more correct methods for conducting the studies and for processing statistical data.

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“…Current treatment options include ointments and moisturizing creams to prevent itchiness, topical corticosteroids, vitamin D analogues, calcineurin inhibitors, phototherapy, keratolytics, and biological monoclonal antibodies (especially in the most severe cases of psoriatic arthritis) [ 3 , 7 – 17 ]. Short-term balneotherapy with thermal spring water constitutes a valid and proven adjuvant treatment of psoriatic lesions [ 18 ]. However, the mechanisms underlying the beneficial effect of thermal water on psoriatic lesions are not fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Thermal Therapy Modulation of the Psoriasis-Associated Skin and Gut Microbiome

Manara,

Beghini,

Masetti

et al. 2023

Dermatol Ther (Heidelb)

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Introduction Psoriasis is a systemic immune-mediated disease primarily manifesting as skin redness and inflammation. Balneotherapy proved to be a successful non-pharmacological option to reduce the skin areas affected by the disease, but the specific mechanisms underlying this effect have not been elucidated yet. Here we test the hypothesis that the effect of thermal treatments on psoriatic lesions could be partially mediated by changes in the resident microbial population, i.e., the microbiome. Methods In this study, we enrolled patients with psoriasis and monitored changes in their skin and gut microbiome after a 12-bath balneotherapy course with a combination of 16S rRNA amplicon sequencing and metagenomics. Changes in the resident microbiome were then correlated with thermal therapy outcomes evaluated as changes in Psoriasis Area and Severity Index (PASI) and Body Surface Area index (BSA). Results The amplicon sequencing analysis of the skin microbiome showed that after thermal treatment the microbiome composition of affected areas improved to approach that typical of unaffected skin. We moreover identified some low-abundance bacterial biomarkers indicative of disease status and treatment efficacy, and we showed via metagenomic sequencing that thermal treatments and thermal water drinking affect the fecal microbiome to host more species associated with favorable metabolic health. Conclusions Changes in lower-abundance microbial taxa presence and abundance could be the basis for the positive effect of thermal water treatment and drinking on the cutaneous and systemic symptomatology of psoriasis. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-023-01036-5.

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Efficacy of hydrotherapy, spa therapy, and balneotherapy for psoriasis and atopic dermatitis: a systematic review

Cited by 13 publications

References 70 publications

The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications

The Benefits of Water from Nitrodi’s Spring: The In Vitro Studies Leading the Potential Clinical Applications

Balneotherapy using thermal mineral water baths and dermatological diseases: a systematic review

Thermal Therapy Modulation of the Psoriasis-Associated Skin and Gut Microbiome

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