Efficacy of Hydroxyapatite Ceramic as a Carrier for Recombinant Human Bone Morphogenetic Protein

Ono, Isao; Gunji, Hironori; Kaneko, Fumio; Saito, Takashi; Kuboki, Yoshinori

doi:10.1097/00001665-199505000-00011

Cited by 77 publications

(43 citation statements)

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“…It is furthermore questionable whether the mechanisms of osteoinduction by BMPs and osteoinduction by inorganic biomaterials are related and, if so, to which extent. The apparent differences between osteoinduction by BMPs and biomaterials are that (1) bone induced by biomaterials is always intramembranous (Ripamonti, 1991;Yuan et al, 2002) while BMP-induced bone is mostly formed via the endochondral pathway (Reddi, 1981), (2) in small animals like rodents bone is very rarely induced by synthetic biomaterials (Ohgushi et al, 1989;Ohgushi et al, 1993;Klein et al, 1994;Yang et al, 1996;Yuan et al, 2006b), but easily by BMPs (Reddi, 1992;Reddi, 1994;Wozney, 1998), (3) bone induction by biomaterials in large animals is rather slow, requiring weeks to months (Gosain et al, 2002;Fujibayashi et al, 2004;Habibovic et al, 2005;Habibovic et al, 2006c;Ripamonti et al, 2010), whereas osteoinduction by BMP-2 and BMP-7 takes place as early as 2-3 weeks upon heterotopic implantation in rodents (Ono et al, 1995;Liu et al, 2005;Kato et al, 2006) and (4) while bone is usually observed inside pores or other "protective" areas of a material Habibovic et al, 2005;Le Nihouannen et al, 2005;Habibovic et al, 2008b), bone formation by BMPs is regularly seen on the periphery of the carrier and even in the soft tissue distant from the carrier surface (Yuan et al, 2001d;Liu et al, 2005).…”

Section: Defi Nitions and Historical Backgroundmentioning

confidence: 99%

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Barradas

Yuan²,

Blitterswijk³

et al. 2011

eCM

446

365

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In the past thirty years, a number of biomaterials have shown the ability to induce bone formation when implanted at heterotopic sites, an ability known as osteoinduction. Such biomaterials -osteoinductive biomaterials -hold great potential for the development of new therapies in bone regeneration. Although a variety of well characterised osteoinductive biomaterials have so far been reported in the literature, scientists still lack fundamental understanding of the biological mechanism underlying the phenomenon by which they induce bone formation. This is further complicated by the observations that larger animal models are required for research, since limited, if any, bone induction by biomaterials is observed in smaller animals, including particularly rodents. Besides interspecies variation, variations among individuals of the same species have been observed. Furthermore, comparing different studies and drawing general conclusions is challenging, as these usually differ not only in the physico-chemical and structural properties of the biomaterials, but also in animal model, implantation site and duration of the study. Despite these limitations, the knowledge of material properties relevant for osteoinduction to occur has tremendously increased in the past decades. Here we review the properties of osteoinductive biomaterials, in the light of the model and the conditions under which they were tested. Furthermore, we give an insight into the biological processes governing osteoinduction by biomaterials and our view on the future perspectives in this research fi eld.

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Section: Defi Nitions and Historical Backgroundmentioning

confidence: 99%

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Barradas

Yuan²,

Blitterswijk³

et al. 2011

eCM

446

365

View full text Add to dashboard Cite

show abstract

“…Investigations have attempted to circumvent this difficulty by adsorbing biological agents onto the surfaces of preformed inorganic layers (168)(169)(170). However, these superficially adsorbed molecules will be rapidly released in an uncontrollable single burst upon implantation (132,171).…”

Section: Organic-inorganic Composite Coatingsmentioning

confidence: 99%

“…Bone regeneration around CaP-coated implants can be strongly enhanced by immobilizing growth factors such as BMP-2 and TGF-β to the implant surface (Table IV) (168,170,183). Growth factors immobilized on CaP resulted in a delayed delivery and a higher stability of the growth factor (103,141).…”

Section: Growth Factor-cap Composite Coatingsmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

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“…This property can be conferred by the introduction of an osteogenic agent [33][34][35][36][37]. Using conventional coating methods, osteogenic agents can be deposited only superficially upon preformed coatings, either by adsorption [33,[38][39][40], by binding to biofunctional proteins [41], or by chemical treatment [42].…”

Section: Biological Functionalization Of Mineral Coatingsmentioning

confidence: 99%