Efficacy of Hyperthermia in Treatment of Recurrent Metastatic Breast Cancer After Long-Term Chemotherapy: A Report of 2 Cases

Sawai, Hirozumi; Kurimoto, Masaaki; Suzuki, Yuka; Yamaguchi, Yoshimi; Murata, Akemi; Suganuma, Enami; Yamamoto, Kazuya; Kuzuya, Hiromasa; Ueno, Shuhei; Koide, Shuji; Koide, Hajime; Kamiya, Atsushi

doi:10.12659/ajcr.926647

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…[ 34 ] However, the single treatment has limited effect on the long-term prognosis due to local or distant residual lesions. [ 35 ] Our survival analysis also showed that LN metastasis decreased survival, which indicates that reduced residual tumor load plays a vital role in young patients with BC. Therefore, multimodality treatments should be encouraged, including chemotherapy, radiotherapy, and surgery, especially in young patients with TNBC.…”

Section: Discussionmentioning

confidence: 68%

Prognostic disparities in young patients based on breast cancer subtype: A population-based study from the SEER database

et al. 2023

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Triple-negative breast cancer (TNBC) is associated with younger age and worse long-term survival. However, the characteristics and prognosis of different subtypes of breast cancer (BC) in young (<40 years) patients have not yet been elucidated. The present population-based study explored the clinical and pathological characteristics of young TNBC patients and investigated their long-term survival. We enrolled patients from the Surveillance, Epidemiology, and End Results database younger than 40 years of age with primary BC. Cases were defined as patients with TNBC (hormone receptor [HR]−/human epidermal growth factor receptor 2 [HER2]−), and controls were patients with other subtypes of BC (HR−/HER2+, HR+/HER2−, and HR+/HER2+). Demographic, pathological, and radiotherapy, chemotherapy, and surgery data were extracted and the overall survival was the primary endpoint. We enrolled 14,234 young patients with BC in the present study, of whom 2798 (19.7%) had TNBC and 11,436 (80.3%) had another BC subtype. A higher proportion of TNBC patients than non-TNBC patients had a more advanced tumor-node-metastasis stage (II–IV 80.5% vs 73.1%, P < .001), and smaller proportions underwent radiotherapy (50.0% vs 53.3%, P = .002) and surgery (91.8% vs 92.9%, P < .001). TNBC was associated with significantly lower 5-year survival rates than other subtypes among patients with regional node positivity (0, 1–3, 4–9, ≥10: 54.2% vs 57.7%, 44.2% vs 55.9%, 31.0% vs 52.0%, and 27.7% vs 38.8%, P < .001) and those with different lymph node ratios (low, intermediate, high: 50.9% vs 56.0%, 34.6% vs 53.6%, and 24.8% vs 44.8%, P < .001). Our research is the first to investigate the relevant characteristics of young TNBC patients in comparison with those of young non-TNBC patients based on the surveillance, epidemiology, and end results database. We found that young TNBC patients have a higher pathological stage and worse long-term survival than young patients with other BC subtypes. These findings have implications in identifying young patients with TNBC for aggressive therapy and further investigations should be performed to explore new multimodal treatments for such patients.

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Section: Discussionmentioning

confidence: 68%

Prognostic disparities in young patients based on breast cancer subtype: A population-based study from the SEER database

et al. 2023

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“…Recently, Shoji et al demonstrated that standardized RF hyperthermia could be established as a potential new treatment for rectal cancer in combination with chemoradiotherapy [ 8 ]. We have also reported the efficacy of hyperthermia combined with chemotherapy for recurrent breast cancer [ 26 ]. Our patient was also treated with 8-MHz RF hyperthermia in combination with chemotherapy, and he did not report any major adverse events.…”

Section: Discussionmentioning

confidence: 99%

Hyperthermia with Chemotherapy for Unresectable Gastric Cancer in a Patient with a Vagus Nerve Stimulator Implant: A Case Report

Sawai¹,

Ueno²,

Yamaguchi³

et al. 2021

Am J Case Rep

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Patient: Male, 55-year-old Final Diagnosis: Gastric cancer Symptoms: Dermatomal rash • muscle weakness Medication: — Clinical Procedure: Chemotherapy • hyperthermia • surgery Specialty: Gastroenterology and Hepatology Objective: Unusual setting of medical care Background: Radiofrequency (RF) hyperthermia is commonly used as an adjunct to established treatment modalities such as chemotherapy and radiotherapy for the management of cancer patients. This case report aims to introduce the use of hyperthermia, in combination with chemotherapy, for the treatment of unresectable gastric cancer in a patient implanted with a vagus nerve stimulator (VNS). Case Report: A 55-year-old man with dermatomyositis, laryngeal squamous cell carcinoma in situ and double synchronous gastric cancer was found to have unresectable gastric disease during surgery despite neoadjuvant chemotherapy. Postoperatively, he received chemotherapy with RF hyperthermia. The patient had a VNS implant to treat epileptic seizures. VNS failure due to RF hyperthermia was an area of significant concern, and the procedures were completed with a full preparation to manage epileptic seizures in the event of its anticipated occurrence. Twenty-one thermotherapies were performed over 21 weeks. After 3 courses of S-1 chemotherapy (12 weeks) with RF hyperthermia without any adverse events, the regimen was changed to S-1+ CDDP combination chemotherapy (SP) and RF hyperthermia. The patient continued to receive treatment with a decrease in the size of the primary gastric tumors as well as lymph node metastases, without major adverse events, until he died due to disseminated disease. Conclusions: We report the first case of unresectable gastric cancer with VNS implants in which chemo-hyperthermal therapy was safe and successful. This case report highlights the importance of providing a multidisciplinary treatment with appropriate measures for patients with intractable cancer who have received special treatments for underlying comorbidities.

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“…The elevated temperature increases the tumour sensitivity to other cancer treatments such as radiotherapy and chemotherapy, enhancing their effectiveness. Such heating can be obtained using non-ionising electromagnetic energy such as radiofrequency (RF), microwaves (MWs), or ultrasound [ 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Review of Thermal and Physiological Properties of Human Breast Tissue

Camilleri

Farrugia

Curto

et al. 2022

Sensors

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Electromagnetic thermal therapies for cancer treatment, such as microwave hyperthermia, aim to heat up a targeted tumour site to temperatures within 40 and 44 °C. Computational simulations used to investigate such heating systems employ the Pennes’ bioheat equation to model the heat exchange within the tissue, which accounts for several tissue properties: density, specific heat capacity, thermal conductivity, metabolic heat generation rate, and blood perfusion rate. We present a review of these thermal and physiological properties relevant for hyperthermia treatments of breast including fibroglandular breast, fatty breast, and breast tumours. The data included in this review were obtained from both experimental measurement studies and estimated properties of human breast tissues. The latter were used in computational studies of breast thermal treatments. The measurement methods, where available, are discussed together with the estimations and approximations considered for values where measurements were unavailable. The review concludes that measurement data for the thermal and physiological properties of breast and tumour tissue are limited. Fibroglandular and fatty breast tissue properties are often approximated from those of generic muscle or fat tissue. Tumour tissue properties are mostly obtained from approximating equations or assumed to be the same as those of glandular tissue. We also present a set of reliable data, which can be used for more accurate modelling and simulation studies to better treat breast cancer using thermal therapies.

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Efficacy of Hyperthermia in Treatment of Recurrent Metastatic Breast Cancer After Long-Term Chemotherapy: A Report of 2 Cases

Cited by 6 publications

References 35 publications

Prognostic disparities in young patients based on breast cancer subtype: A population-based study from the SEER database

Prognostic disparities in young patients based on breast cancer subtype: A population-based study from the SEER database

Hyperthermia with Chemotherapy for Unresectable Gastric Cancer in a Patient with a Vagus Nerve Stimulator Implant: A Case Report

Review of Thermal and Physiological Properties of Human Breast Tissue

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