Efficacy of<i>Berberis vulgaris</i>Aqueous Extract on Viability of Echinococcus Granulosus Protoscolices

Rouhani, Soheila; Salehi, Nima; Kamalinejad, Mohammad; Zayeri, Farid

doi:10.3109/08941939.2013.818746

Cited by 24 publications

(17 citation statements)

References 21 publications

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“…Since the past decades, the use of natural compounds derived from plant has been frequently seen in traditional remedies [10]. Various investigations have examined the scolicidal effects of essential oils or extracts of plants in today's climate [12,21,[28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Phenolic compound found in some scolicidal agents such as Satureja khuzistanica essential oils [36], Peganum harmala [29], garlic [21], ginger oil (Zingiber officinale) [30], Berberis vulgaris L. [31], aqueous extracts of Olea europaea leaves [37], methanolic fruit powder extract of Mallotus philippinensis [16], extract of Cardaria draba (L.) [38]. ajowan (Trachyspermum ammi L.) essential oil [39], Lepidium sativum essential oil [40], sumac (Rhus coriaria) [13,41], Sambucus ebulus [28,42].…”

Section: Discussionmentioning

confidence: 99%

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Scolicidal Effects of Gallic Acid, One of the Major Compounds of Plants, on Protoscolices of Hydatid Cyst

Larki

Jalali

Goodarzi

2017

Zahedan J Res Med Sci

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Background: Today's, the recurrent of hydatidosis remain as a concern in many surgeries. Exposure of a suitable effective scolicidal agent with protoscolex-rich fluid can prevent these complications. In recent studies more have been considered to importance of natural products particularly herbal medcines to evaluate their scolicidal effects. Gallic acid a type of organic acid is one of the main known effective biological phenolic substances of plants. Objectives: The aim of this study was to evaluate the effect of Gallic acid on protoscolices of hydatid cysts in in vitro. Methods: In this experimental study, the protoscolices were obtained from liver hydatid cysts of infected sheep. Gallic acid solution was used at the concentration of 25, 30 and 35 mg/mL for 1, 3, and 5 minutes. The live protoscolices were detected by 0.1% eosin dye. Data analysis was performed by SPSS version 11.5 and one-way ANOVA test. Results:The Gallic acid at the concentration of 25 mg/mL disabled 35.65%, 52.21% and 65.38% of protoscolices after 1, 3 and 5 min of faced time together, respectively. Also, the scolicidal rate of Gallic acid at concentration of 30 mg/mL was 29.92%, 63.80% and 67.76% after 1, 3 and 5 min, respectively. It was observed that concentration of 35 mg/mL Gallic acid on protoscolices caused 92.08% and 100% mortality rate of parasites after 1 and 3 minutes, respectively (compared with 9.9% in control groups). Conclusions:The findings of present study showed that Gallic acid as an effective constituent of some herbal scolicidal agent can be considered as responsible for killing of protoscolices. However, further studies will be needed to confirm this phytochemicals active component in animal models.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Scolicidal Effects of Gallic Acid, One of the Major Compounds of Plants, on Protoscolices of Hydatid Cyst

Larki

Jalali

Goodarzi

2017

Zahedan J Res Med Sci

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“…Fata et al [15] also found that ethanolic extract of B. vulgaris significantly decreased ulcer size of cutaneous leishmaniasis of BALB/c mice after 2 weeks. Recently, Rouhani et al [30] reported that aqueous extract of B. vulgaris fruits had an effective scolicidal activity at low concentration (4 mg/mL) and short exposure time (5 min). Thus, the present results were in agreement with those of previous studies in demonstrating antiparasitic activities of B. vulgaris and its bioactive compound, berberine.…”

Section: Discussionmentioning

confidence: 99%

Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine

et al. 2014

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In this study, in vitro antidermatophytic activity against Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, and Microsporum gypseum was studied by disk diffusion test and assessment of minimum inhibitory concentration (MIC) using CLSI broth macrodilution method (M38-A2). Moreover, antileishmanial and cytotoxicity activity of B. vulgaris and berberine against promastigotes of Leishmania major and Leishmania tropica were evaluated by colorimetric MTT assay. The findings indicated that the various extracts of B. vulgaris particularly berberine showed high potential antidermatophytic against pathogenic dermatophytes tested with MIC values varying from 0.125 to >4 mg/mL. The results revealed that B. vulgaris extracts as well as berberine were effective in inhibiting L. major and L. tropica promastigotes growth in a dose-dependent manner with IC50 (50% inhibitory concentration) values varying from 2.1 to 26.6 μg/mL. Moreover, it could be observed that berberine as compared with B. vulgaris exhibited more cytotoxicity against murine macrophages with CC50 (cytotoxicity concentration for 50% of cells) values varying from 27.3 to 362.6 μg/mL. Results of this investigation were the first step in the search for new antidermatophytic and antileishmanial drugs. However, further works are required to evaluate exact effect of these extracts in animal models as well as volunteer human subjects.

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“…However, the majority of these scolicidal agents have been reported to cause many undesirable side-effects to human which limit their clinical applications (Besim et al, 1998;Moazeni and Alipour-Chaharmahali, 2011;Moazeni and Nazer, 2010). Some other laboratory studies have recently reported the scolicidal activity of acidic and alkaline solutions (Moazeni and Larki, 2010), biogenic selenium nanoparticles (Mahmoudvand et al, 2014) and low-voltage direct electric current (Dalimi et al, 2005) and some plant extracts such as garlic (Allium sativum) (Moazeni and Nazer, 2010), Berberis vulgaris (Rouhani et al, 2013), A. sativum (Sadjjadi et al, 2008), Zataria multiflora (Moazeni and Roozitalab, 2012), and Trachyspermum ammi L. . However, the effects of such agents on human cells were not investigated in vitro and in vivo.…”

Section: Scolicidal Effect Of Fbgmentioning

confidence: 96%

Optimization of fluoride-containing bioactive glasses as a novel scolicidal agent adjunct to hydatid surgery

et al. 2015

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Efficacy ofBerberis vulgarisAqueous Extract on Viability of Echinococcus Granulosus Protoscolices

Abstract: The scolicidal activity was very effective in low concentration (4 mg/ml) and short exposure time (5 min). Therefore, after being examined in vivo and additional experiments, it may be used as a suitable and effective scolicidal in surgery.

Cited by 24 publications

References 21 publications

Scolicidal Effects of Gallic Acid, One of the Major Compounds of Plants, on Protoscolices of Hydatid Cyst

Scolicidal Effects of Gallic Acid, One of the Major Compounds of Plants, on Protoscolices of Hydatid Cyst

Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine

Optimization of fluoride-containing bioactive glasses as a novel scolicidal agent adjunct to hydatid surgery

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