Efficacy of Majoon-e-Seer Alvi Khan in dyslipidemia: a single blind randomized standard controlled clinical trial

Abstract

Objectives Majoon-e-Seer Alvi Khan, a compound Unani formulation, has been indicated in disease conditions simulating dyslipidemia. The present study was done to substantiate the efficacy of Majoon-e-Seer Alvi Khan (MSAK) in dyslipidaemia on scientific parameters. Methods A randomized, single-blind, Standard controlled, clinical trial was carried out on 40 patients of dyslipidemia who were randomly allocated into test (n=30) and control (n=10) groups. The test drug, MSAK, and control drug, tablet Atorvastatin was given to the respective group for 60 days along with lifestyle modification. Results The test drug significantly alleviated the symptoms of subjective parameters (p<0.05). There was a statistically significant reduction in lipid profile of the patients in the test group (p<0.05) than control drug treatment. Conclusions The study evidenced that Majoon-e-Seer Alvi Khan is potentially effective and safe in the treatment of dyslipidemia. However, a multicentre study with a robust study design is required to generalize the results.

Dyslipidemia and its concept in Unani medicine: A review

“…They can also balance the Akhlat (Humors), such as Badyan (Foeniculm vulgare) [37] , Bikh Ajmod (Apium graveolens) [38] , Gudmar Booti (Gymnema sylvestre) [39] , Halela (Terminalia chebula) [40,41] , Lehsun (Allium sativum) [42,43] , Kaloonji (Nigella Sativa) [42] , Luk Maghsul (Laccifer lacca) [43] , Methi (Trigonella foenum-graecum) [44] , Sandrus (Trachelobium hornemanianum), Saad kofi (Cyperus rotundus), Soya (Anethum sowa) [45] , Sumbuluttib (Valeriana officinalis), Tukhme Karafs (Apium graveolens) [46] and Tukhme Suddab (Ruta graveolens) [47] Kasni (Cichorium intybus) [47] , Maku (Solanum nigrum) [48] , Afsanteen (Artemisia absinthium) [49] , Muquil (Commiphora mukul) [50] , Chhal Arjun (Terminalia arjuna) [51] , Badranjboya (Mellisa officinalis) [52] , Abresham (Bombyx mori) [53] , which have been reported as having antihyperlipidemic activity. Various Unani formulation have been used by physicians, based on their clinical experiences, to manage dyslipidemia and Farbahi such as Safoof Kalonji [54] , Habbe Sundarus [35] , Qurs Luk [55] , Itriphal Sagheer [56] , Majoon Sheer Alvi Khan [57] and Safoof Muhazzil [58,59] . [60] are the same as those stated by Sina [11] , Rushd [11] , and Nafis [16] (deranged cold temperament).…”