Efficacy of Ibuprofen and Ibuprofen/Acetaminophen on Postoperative Pain in Symptomatic Patients with a Pulpal Diagnosis of Necrosis

Wells, L. Kevin; Drum, Melissa; Nusstein, John; Reader, Al; Beck, Mike

doi:10.1016/j.joen.2011.08.026

Cited by 43 publications

(31 citation statements)

References 30 publications

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“…However, the preoperative ad- Wells et al (33) found that there were decreases in postoperative pain levels with the preoperative use of ibuprofen, a finding in harmony with ours. Since there have not been any studies on the effect of preoperative administration of antihistamine on postoperative pain, a direct comparison here between present and previous findings here is not possible.…”

Section: Discussionsupporting

confidence: 88%

The Effect of Preoperative Administration of Antihistamine, Analgesic and Placebo on Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Controlled Trial

Arslan¹,

Gundogdu²

2017

Eur Endod J

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Objective:To compare the effect of preoperative administration of an antihistamine, an analgesic, or a placebo on postoperative pain in maxillary molar teeth with symptomatic apical periodontitis. Design: A randomized, controlled trial. Methods: Population: A total of 51 patients with moderate-to-severe maxillary molar tooth pain who have undergone a root canal treatment. Intervention: Preoperative administration of either an antihistamine or an analgesic. Control: Versus placebo Outcomes: Reduction in postoperative pain? The data were analyzed with chi-square, one-way analysis of variance (ANOVA) and least significant difference (LSD) post-hoc tests. Results: At days 1 and 3, preoperative administration of the antihistamine and analgesic resulted in lower pain levels than the placebo. At days 5 and 7, however, while preoperative administration of the antihistamine still resulted in less pain than the placebo, there was no significant difference between the analgesic and placebo (P>0.05). Conclusion: Within the limitations of the present study, the preoperative administration of an antihistamine can be beneficial in reducing the postoperative pain of endodontic treatments.

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Section: Discussionsupporting

confidence: 88%

The Effect of Preoperative Administration of Antihistamine, Analgesic and Placebo on Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Controlled Trial

Arslan¹,

Gundogdu²

2017

Eur Endod J

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“…In a similar study, ibuprofen management significantly reduced pain at 4 and 8 hours after surgery (20). Moreover, Wells et al (2011) compared the use of ibuprofen against ibuprofen/acetaminophen to reduce pain in a randomized double-blind study and found a decrease in pain levels and analgesic use over time for both groups (21,22). This combination therapy was very effective in decreasing pain score, needing an analgesic dose after surgery, and increasing drug tolerability.…”

Section: Discussionmentioning

confidence: 94%

Clinical Trial of Combination of Acetaminophen, Ibuprofen and Caffeine on Pain Relief and Analgesic Use After Impacted Lower Third Molar Surgery

2017

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Objectives: Relieving a very painful procedure such as impacted lower third molar surgery by combining analgesics into a single product using their synergistic effects is favorable. We designed a prospective, randomized, double-blind clinical trial to study the beneficial effect of the combination of acetaminophen, ibuprofen, and caffeine on reducing the severity of postoperative pain after impacted lower third molars surgery. Methods:This was a double-blinded clinical trial on 108 patients scheduled for impacted third molar surgery. The patients were randomly assigned into 2 groups. Two hours before the procedure the intervention group received combination therapy of acetaminophen (600 mg), ibuprofen (400 mg), and caffeine (15 mg) as pre-emptive analgesia, and the control group received placebo. All patients received gelofen capsules (400 mg) uniformly after the intervention as PRN. Postoperative assessment of pain severity [using a 10-point visual analog scale (VAS)] and analgesic consumption was performed at 2, 4, 6, and 8 hours after the operation. All statistical analyses were performed using SPSS software (version 19.0, SPSS Inc., Chicago, Illinois), with chi-square test or Fisher's and Mann-Whitney U test. Results:The severity of preoperative pain did not differ before receiving the first dose of study drugs. However, at any time points after the surgery, the mean pain score was significantly lower in the group who received combination regimen than the control group (P < 0.001). In a general linear model, using a repeated-measures analysis, concerning the analgesic dose administered after the surgery, the mean number of doses in 8 hours was 0.96 for the combination therapy group and 1.8 for the control group, with a significant difference (P = 0.022). Conclusions:The pre-emptive combination therapy including acetaminophen, ibuprofen, and caffeine can be used efficiently to control postoperative pain after impacted third molar surgery.

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“…It has been used previously to reduce the post-operative swelling and trismus following surgical removal of impacted third molar. 8 It was able to produce a significant reduction of edema in the first 4 postoperative days as compared to systemic administration of the drug. Recently, dexamethasone was reported to be a potent inhibitor of prostaglandins and interleukins in inflamed gingival and periodontal tissues, to almost control level.…”

Section: Discussionmentioning

confidence: 95%

“…No adverse drug responses have been reported. [6][7][8] Marshall and Walton reported that 4 mg of dexamethasone injected intramuscularly significantly reduced post treatment endodontic pain when compared with a placebo. 7 Krasner and Jackson also reported a statistically significant reduction in post treatment pain in the patients given dexamethasone.…”

Section: Introductionmentioning

confidence: 99%

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Frequency of post obturation pain by using ibuprofen and ibuprofen/dexamethasone infiltration in single visit root canal treatment cases

Rana

Rana²,

Akhtar³

et al. 2018

Int J Clin Trials

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Background: Pain after root canal treatment is a challenging problem for the operative dentists over the last few years. The development of pain is dependent on the intensity of tissue damage. Inflammation is characterized by a series of vascular events in response to tissue injury. The release of mediators is responsible for much of the pain. The rationale of this study is to use NSAIDs alone or in combination with dexamethasone to reduce post treatment swelling and pain following endodontic therapy. The objective of the study was to compare the frequency of post obturation pain by using ibuprofen or ibuprofen/ dexamethasone infiltration in single visit endodontic cases.Methods: This study was carried out in the Operative Dentistry, Department (AFID), Rawalpindi, Pakistan from December 2015 to May 2016 after approval from the Institutional Ethical Review Board. After an informed consent, 128 patients fulfilling inclusion criteria were divided in to two equal groups. In Group A, after root canal treatment, an additional single shot local infiltration of 0.5 mg dexamethasone was given in periapical area. Both the patient groups were prescribed ibuprofen 400 mg three times a day. Patient’s pain response was recorded after 24 hours of treatment, using visual analogue scale. Data was analyzed using SPSS version 17.Results: After 24 hours, 6 (9.4%) patients showed the pain in group A while 16 (25.0%) patients complained of pain in group B. Conclusions: The results of this study showed, group A showed less postoperative pain as compared to group B where only ibuprofen was given.

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Efficacy of Ibuprofen and Ibuprofen/Acetaminophen on Postoperative Pain in Symptomatic Patients with a Pulpal Diagnosis of Necrosis

Cited by 43 publications

References 30 publications

The Effect of Preoperative Administration of Antihistamine, Analgesic and Placebo on Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Controlled Trial

The Effect of Preoperative Administration of Antihistamine, Analgesic and Placebo on Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Controlled Trial

Clinical Trial of Combination of Acetaminophen, Ibuprofen and Caffeine on Pain Relief and Analgesic Use After Impacted Lower Third Molar Surgery

Frequency of post obturation pain by using ibuprofen and ibuprofen/dexamethasone infiltration in single visit root canal treatment cases

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