Efficacy of ibuprofen and paracetamol and diclofenac sodium and paracetamol combination on postoperative pain following root canal preparation in a randomized placebo-controlled study

Makkar, Sameer; Kaler, Nisha; Dhawan, Rajan; Mann, Navjot Singh; Pasricha, Shinam

doi:10.4103/0976-6944.101671

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…The pain VAS is a continuous scale comprising a horizontal (HVAS) or vertical (VVAS) line, usually 10 centimeters in length, with two endpoints: "no pain" and "extremely painful" [16,17]. However, in this study, the Verbal Descriptor Scale (VDS) was utilized to facilitate the report of pain among patients who were anticipated to have difficulty conceptualizing the VAS, as well as to ensure participants' comprehension, understanding and collaboration [18,19]. Notably, the World Health Organization (WHO) has used VDS as a replacement of VAS in studies focusing on analgesic scale in cancer patients [20].…”

Section: Assessment Of Post-operative Dental Painmentioning

confidence: 99%

Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial

et al. 2019

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One of the most common post-operative complications of tooth extraction is pain. Oral analgesics, namely loxoprofen sodium and diclofenac potassium, are often prescribed; however, the efficacy of these drugs irrespective of gender and type of extraction has not been tested. Therefore, this study aimed to compare the efficacy of these two drugs in post-dental extraction pain relief among male and female patients in cases of simple and surgical tooth extraction. A single-center, triple-blind, randomized clinical trial was conducted among 100 male and female patients who underwent tooth extraction at Taibah University Dental College and Hospital in Al-Madinah, Saudi Arabia. The patients reported their pain post-operatively after 6 hours and every 12 h for 3 days using the Verbal Descriptor Scale (e.g., “no pain”, “mild pain”). Descriptive statistics and chi-square tests were run to analyze the data. An equal number of patients received either the drug loxoprofen sodium or diclofenac potassium and completed the study follow-up. Patients allocated to the diclofenac potassium drug group after 36 h were statistically significantly in their reporting of “no pain” and “mild pain” compared to patients allocated to the loxoprofen sodium group (86% vs. 66%, respectively; p = 0.019), irrespective of gender or type of tooth extraction. However, both groups demonstrated comparable (p > 0.05) post-operative pain relief over the other aforementioned allocated time intervals. In conclusion, the diclofenac potassium group had slightly better control over post-operative pain than the group receiving loxoprofen sodium.

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Section: Assessment Of Post-operative Dental Painmentioning

confidence: 99%

Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial

et al. 2019

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“…Интерес представляют результаты исследования, посвященного купированию болевого синдрома у пациентов с острым пульпитом [14]. Включенные в исследование пациенты получали нестероидные противовоспалительные препараты (НПВП) и анальгетики (парацетамол, ибупрофен, диклофенак) в различных комбинациях, в качестве плацебо использовался нейробион для перорального применения.…”

Section: радикулопатии и нейропатииunclassified

The use of neurobion in neurological practice

Камчатнов

Umarova

Chugunov

2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Vitamins are actively involved in many metabolic processes of the nervous system. Their deficit may cause severe and, sometimes, irreversible consequences. Mechanisms of the therapeutic effects of the vitamin B complex neurobion are considered. Results of the studies on the efficacy and safety of neurobion in patients with polyneuropathies, including those caused by diabetes mellitus, pain syndromes of origin (skeletal/muscle pain, trauma etc) are presented. The necessity of using neurobion in treatment of a wide spectrum of nervous system diseases is emphasized.

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“…Both IBU ( 6 ) and diclofenac ( 14 ) have been shown to diminish PEP. A trial by Makkar et al ( 15 ) showed that a single-dose combination of diclofenac sodium + paracetamol had more analgesic effects on PEP than a combination of IBU + paracetamol. Nevertheless, another study found that a single-dose combination of IBU + paracetamol had no statistically significant difference from a single-dose combination of DFK + paracetamol on PEP ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Analgesic Efficacy of Ibuprofen and Diclofenac Potassium on Postoperative Endodontic Pain in Maxillary and Mandibular First Molars with Irreversible Pulpitis: A Randomized Controlled Trial.

Vatankhah¹

2022

Eur Endod J

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Objective The management of postoperative endodontic pain (PEP) is essential to contemporary endodontic practice. Diclofenac and ibuprofen (IBU) are two of the most widely-used non-steroidal anti-inflammatory analgesics. However, their comparative data are neither sufficient nor conclusive. This prospective randomised clinical trial aimed to compare the analgesic efficacy of diclofenac potassium (DFK) with IBU on PEP in maxillary and mandibular first molars diagnosed with irreversible pulpitis after single-visit non-surgical root canal treatment. Methods Sixty-four patients were randomised into two groups of DFK (n=32) and IBU (n=32), using the stratified permuted randomisation method, and 61 participants completed the trial. After root canal treatment, patients randomly received IBU 400 mg every 6 hours (n=31) or DFK 50 mg every 8 hours (n=30) for 24 hours. Patients recorded their pain level on 0-100 mm visual analogue scales (VAS) at 2, 4, 6, 12, and 24 hours after the treatment. Recorded VAS scores and the number of pain-free patients (VAS<5) were compared between the two groups. A generalised linear estimation equation model, Chi-Square test, and Mann–Whitney U test were used to analyse the data. Results The mean overall PEP score was statistically significantly lower in the DFK group than the IBU group with a p value of 0.030. Pain scores at 2 (p=0.034), 4 (p=0.021), and 24 hours (p=0.042) after the treatment were also significantly lower for DFK than IBU. The number of pain-free patients was also significantly higher in the DFK group at 2-hour (p=0.015) and 4-hour (p=0.048) time points and overall (p=0.013) compared to the IBU group. There was no adverse effect observed in either group. Conclusion Based on the results, taking multi-dose DFK 50 mg by the clock had better analgesic outcomes than multi-dose IBU 400 mg for PEP management.

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Efficacy of ibuprofen and paracetamol and diclofenac sodium and paracetamol combination on postoperative pain following root canal preparation in a randomized placebo-controlled study

Cited by 9 publications

References 4 publications

Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial

Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial

The use of neurobion in neurological practice

Analgesic Efficacy of Ibuprofen and Diclofenac Potassium on Postoperative Endodontic Pain in Maxillary and Mandibular First Molars with Irreversible Pulpitis: A Randomized Controlled Trial.

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