Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study

Lustenberger, Francine D.; Grätz, Klaus W.; Mutzbauer, Till S.

doi:10.1007/s10006-010-0255-4

Cited by 28 publications

(23 citation statements)

References 15 publications

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“…In a study comparing the efficacy of ibuprofen versus lornoxicam after third molar surgery, it was reported that effective pain relief was provided and there was no significant difference between the groups [29] . The concentration of prostaglandins in acutely injured tissue reaches its maximum level at 3 or 4 h after injury with the result of a peak intensity of postoperative pain [29] . Seventy-five percent of the VASR scores at 4 and 8 h were lower than 50 mm for all of the three groups.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Analgesia in Impacted Third Molar Surgery: The Role of Preoperative Diclofenac Sodium, Paracetamol and Lornoxicam

Oncul

Yazicioglu²,

Alanoğlu³

et al. 2011

Med Princ Pract

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Objective: The aim of this study was to compare the postoperative analgesic effects of preoperative intravenous (i.v.) paracetamol, diclofenac sodium and lornoxicam (nonsteroidal anti-inflammatory drugs). Subjects and Methods: Sixty patients with impacted third molar who underwent surgical removal were randomly allocated into three groups: group P (n = 20), group D (n = 20) and group L (n = 20). Group P received preoperatively 1 g paracetamol i.v., group D 75 mg diclofenac sodium i.m. and group L 8 mg lornoxicam i.v. Postoperative pain intensity, additional consumption of analgesics postoperatively and postoperative complications were compared among groups. Results: The groups were comparable for pain scores (p > 0.05). Maximum pain scores were recorded in postoperative 4th h in all groups (group L 22, 14–44 mm; group P 24, 13–43 mm; group D 14, 10–24 mm, p = 0.117). Patients experienced high satisfaction scores which were comparable among groups (group L 85, 75–100 mm; group P 87, 70–95 mm; group D 84, 77–98 mm, p = 0.457). Conclusion: Preoperative intramuscular diclofenac, intravenous paracetamol and lornoxicam effectively decreased the pain scores. The patients were satisfied with the three postoperative pain management regimens.

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Section: Discussionmentioning

confidence: 99%

Postoperative Analgesia in Impacted Third Molar Surgery: The Role of Preoperative Diclofenac Sodium, Paracetamol and Lornoxicam

Oncul

Yazicioglu²,

Alanoğlu³

et al. 2011

Med Princ Pract

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“…Lustenberg et al [22] compared the analgesic efficacy and tolerability of a pre-emptive/post-surgical 4-day regimen of oral ibuprofen (400mg) with that of Lornoxicam (8mg) and concluded that both drugs were equally effective in managing pain after third-molar extraction.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of NSAID (Lornoxicam) After Impacted Third-Molar Surgery With/Without Conscious Sedation: A Double-Blind Randomized Clinical Study

Özgül¹,

Or²

2018

IJDSR

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Aim: Pain and swelling following surgery for impacted third molars can be controlled by various methods. This study compared the analgesic and anti-inflammatory efficacy and tolerability of lornoxicam, aspirin and a placebo with and without conscious sedation in impacted mandibular third-molar surgery. Materials and Methods: 60 patients undergoing third-molar surgery were divided into 2 groups of conscious sedation and routine local anesthesia (n=30). Both groups were divided into three subgroups (n=10) that received either Lornoxicam, aspirin, or a placebo postoperatively. Results: In both the conscious sedation and local anesthesia groups, swelling reduction was significantly greater with Lornoxicam compared to aspirin and placebo (p< .05). Pain values were significantly lower for Lornoxicam group compared to both aspirin and placebo groups at 6, 12 and 24 hours postoperatively (p< .05). Conclusion: Conscious sedation resulted less pain and swelling. Moreover, Lornoxicam was found to be an effective analgesic and anti-inflammatory agent for use in conjunction with oral surgery.

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“…It is as effective as other NSAIDs in relieving pain of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low backache. In one randomized controlled trial (RCT), ibuprofen and lornoxicam were similar in terms of pain intensity scores starting from 2 h to 4th day of post surgical dental extraction as well as number and severity of AEs [8]. The efficacy and tolerability of lornoxicam were equivalent to diclofenac and higher than placebo based on pain intensity difference and total area under pain relief scores in the treatment of acute sciatica/ lumbo-sciatica [20].…”

Section: Commentsmentioning

confidence: 99%

“…All NSAIDs have been associated with gastrointestinal adverse effects (AEs) such as nausea, dyspepsia, peptic ulcer, and diarrhea. Ibuprofen is the first NSAID to be approved for over-the-counter (OTC) use [8]. It is widely used for mild to moderate type of acute pain (e.g.…”

mentioning

confidence: 99%

Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study

Patel

Patel²,

Acharya

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study

Abstract: Ibuprofen 400 mg and lornoxicam 8 mg were rated as equal and effective pain treatment medication after wisdom tooth surgery. In comparison, neither of the drugs provided clinical advantages nor did side effects occur more frequently after one of the analgesics.

Cited by 28 publications

References 15 publications

Postoperative Analgesia in Impacted Third Molar Surgery: The Role of Preoperative Diclofenac Sodium, Paracetamol and Lornoxicam

Postoperative Analgesia in Impacted Third Molar Surgery: The Role of Preoperative Diclofenac Sodium, Paracetamol and Lornoxicam

Efficacy of NSAID (Lornoxicam) After Impacted Third-Molar Surgery With/Without Conscious Sedation: A Double-Blind Randomized Clinical Study

Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study

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