Efficacy of Improvised Topical Zinc (1%) Ora-Base on Oral Mucositis during Cancer Chemo-Radiation—A Randomized Study

Chaitanya, Nallan Csk; Badam, Rajkumar; Aryasri, Ankisetti Srikanth; Pallarla, Srinivasrao; Garlpati, Komali; Akhila, M V; Soni, Pratima; Gali, Sanju; Inamdar, Pavitra; Bontala, Parinita; Zaheer, Khadija; Prabhath, Thirupathi; Swetha, Alugubelli

doi:10.3177/jnsv.66.93

Cited by 9 publications

(16 citation statements)

References 11 publications

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“…Multiple trials tested a variety of botanical and natural products to prevent and/or treat mucositis in a range of different cancer types receiving different chemotherapy and/or radiation therapy treatments. [167][168][169][170][171][172][173][174]188,189,[195][196][197][198][199][200][201][202][211][212][213][214][215][216][217][218][219][220][221][222][223][224][225][226][227][228][229] Interventions included chamomile, 167,168 propolis, [169][170][171] glutamine, 172-185 curcumin, [188][189][190] botanical teas, 195,196 mouthwashes, …”

Section: Pain During Radiation Therapy And/or Oral Mucositismentioning

confidence: 99%

“…[167][168][169][170][171][172][173][174]188,189,[195][196][197][198][199][200][201][202][211][212][213][214][215][216][217][218][219][220][221][222][223][224][225][226][227][228][229] Interventions included chamomile, 167,168 propolis, [169][170][171] glutamine, 172-185 curcumin, [188][189][190] botanical teas, 195,196 mouthwashes, [197][198][199]…”

Section: Pain During Radiation Therapy And/or Oral Mucositismentioning

confidence: 99%

See 1 more Smart Citation

Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline

Mao

Ismaila

Bao

et al. 2022

JCO

143

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PURPOSE The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other health care providers on integrative approaches to managing pain in patients with cancer. METHODS The Society for Integrative Oncology and ASCO convened an expert panel of integrative oncology, medical oncology, radiation oncology, surgical oncology, palliative oncology, social sciences, mind-body medicine, nursing, and patient advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2021. Outcomes of interest included pain intensity, symptom relief, and adverse events. Expert panel members used this evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS The literature search identified 227 relevant studies to inform the evidence base for this guideline. RECOMMENDATIONS Among adult patients, acupuncture should be recommended for aromatase inhibitor–related joint pain. Acupuncture or reflexology or acupressure may be recommended for general cancer pain or musculoskeletal pain. Hypnosis may be recommended to patients who experience procedural pain. Massage may be recommended to patients experiencing pain during palliative or hospice care. These recommendations are based on an intermediate level of evidence, benefit outweighing risk, and with moderate strength of recommendation. The quality of evidence for other mind-body interventions or natural products for pain is either low or inconclusive. There is insufficient or inconclusive evidence to make recommendations for pediatric patients. More research is needed to better characterize the role of integrative medicine interventions in the care of patients with cancer. Additional information is available at https://integrativeonc.org/practice-guidelines/guidelines and www.asco.org/survivorship-guidelines .

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Section: Pain During Radiation Therapy And/or Oral Mucositismentioning

confidence: 99%

Section: Pain During Radiation Therapy And/or Oral Mucositismentioning

confidence: 99%

Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline

Mao

Ismaila

Bao

et al. 2022

JCO

143

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“…Studies have also shown that amla extract has strong anti-inflammatory effects and inhibits microbial infection-induced expression of the neutrophil chemokines interleukin (IL)-8, GRO-alpha, GRO-gamma, and pro-inflammatory cytokine, IL-6 in the bronchial epithelial cells (Nicolis et al 2008). In addition to the immunomodulatory effect of amla (Singh et al 2013), the synergistic effects of turmeric, amla, and black pepper are well reported in the scientific literature (Rawal et al 2014;Pitchaiah et al 2017;Abdul Manap et al 2019;Chaitanya et al 2020). Furthermore, our earlier studies suggested the prophylactic efficacy of these three components individually against diabetic complications (Suryanarayana et al 2004;Muthenna et al 2009;Puppala et al 2012;Rao et al 2012) which motivated us to investigate the combined effect of turmeric, amla, and black pepper (TAB) against sepsis-induced ALI using a rat model.…”

Section: Tabmentioning

confidence: 97%

Anti-inflammatory potential of turmeric, amla, and black pepper mixture against sepsis-induced acute lung injury in rats

et al. 2022

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“…In another study, nanocurcumin (80 mg/day for 4 weeks) reduced lesion size, pain, and burning sensation in patients with OLP ( n = 57) . The application of ora-base gel containing curcumin reduced the severity of oral mucositis during chemo-radiation in patients with HNC . These studies showed the remarkable potential of turmeric and curcumin in the prevention and treatment of oral diseases.…”

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

“…297 The application of ora-base gel containing curcumin reduced the severity of oral mucositis during chemo-radiation in patients with HNC. 298 These studies showed the remarkable potential of turmeric and curcumin in the prevention and treatment of oral diseases. Hepatocellular carcinoma, or liver cancer, is the third most common cause of cancer-related mortality, with approximately 8,30,000 deaths in 2020.…”

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Kunnumakkara

Hegde

Dey

et al. 2023

ACS Pharmacol. Transl. Sci.

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Turmeric (Curcuma longa) has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Almost 7000 scientific papers on turmeric and almost 20,000 on curcumin have been published in PubMed. Scientific reports based on cell culture or animal studies are often not reproducible in humans. Therefore, human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug. Herein, we conducted an extensive literature survey on PubMed and Scopus following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The keywords "turmeric and clinical trials" and "curcumin and clinical trials" were considered for data mining. A total of 148 references were found to be relevant for the key term "turmeric and clinical trials", of which 70 were common in both PubMed and Scopus, 44 were unique to PubMed, and 34 were unique to Scopus. Similarly, for the search term "curcumin and clinical trials", 440 references were found to be relevant, of which 70 were unique to PubMed, 110 were unique to Scopus, and 260 were common to both databases. These studies show that the golden spice has enormous health and medicinal benefits for humans. This Review will extract and summarize the lessons learned about turmeric and curcumin in the prevention and treatment of chronic diseases based on clinical trials.

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Efficacy of Improvised Topical Zinc (1%) Ora-Base on Oral Mucositis during Cancer Chemo-Radiation—A Randomized Study

Cited by 9 publications

References 11 publications

Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline

Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline

Anti-inflammatory potential of turmeric, amla, and black pepper mixture against sepsis-induced acute lung injury in rats

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

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