Abstract:Background: Integrated Chinese and Western medicine (integrated medicine) is routinely used in the treatment of coronavirus disease 2019 (COVID-19) in China. In this study, we undertook a systematic review and meta-analysis of published randomized controlled trials (RCTs) to evaluate the efficacy of integrated medicine therapy for patients with COVID-19.Methods: In this meta-analysis, we searched PubMed, Embase, Web of Science, SinoMed, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), and… Show more
“…As of October 20, 2021, the literature search yielded 674 results. After removing duplicates and excluding papers based on title and abstract screening, 21 SRs ( Ang et al, 2020 ; Du et al, 2021 ; Fan et al, 2020 ; Fan et al, 2021 ; Jiang et al, 2021 ; Li et al, 2021 ; Liang et al, 2021 ; Liu et al, 2021 ; Liu et al, 2020 ; Luo et al, 2021 ; Pang et al, 2020 ; Sun et al, 2020 ; Wang et al, 2021a ; Wang et al, 2021b ; Wu et al, 2021 ; Xiong et al, 2020 ; Yan et al, 2021 ; Yin et al, 2021 ; Zeng et al, 2020 ; Zhou et al, 2020 ; Zhuang et al, 2021 ) matching the inclusion criteria were identified ( Figure 1 ). Figure 1 Study selection process.…”
“…As of October 20, 2021, the literature search yielded 674 results. After removing duplicates and excluding papers based on title and abstract screening, 21 SRs ( Ang et al, 2020 ; Du et al, 2021 ; Fan et al, 2020 ; Fan et al, 2021 ; Jiang et al, 2021 ; Li et al, 2021 ; Liang et al, 2021 ; Liu et al, 2021 ; Liu et al, 2020 ; Luo et al, 2021 ; Pang et al, 2020 ; Sun et al, 2020 ; Wang et al, 2021a ; Wang et al, 2021b ; Wu et al, 2021 ; Xiong et al, 2020 ; Yan et al, 2021 ; Yin et al, 2021 ; Zeng et al, 2020 ; Zhou et al, 2020 ; Zhuang et al, 2021 ) matching the inclusion criteria were identified ( Figure 1 ). Figure 1 Study selection process.…”
“…Unfortunately, the argument has become political recently, making TCM an issue of political claims, which distorts what medicine should focus on and has hampered efforts to fight against COVID‐19 [ 38 ]. Despite this, there are many studies that have called for breaking down boundaries between Eastern and Western medicine and suggest that a proper combination of TCM and Western medicine could better control the disease progression and post‐disease syndromes [ 39 , 40 , 41 , 42 , 43 , 44 ]. Herein, as part of the efforts for probing these issues, TCM2COVID, a comprehensive database, documents the detailed information on anti‐COVID TCM treatments and is undoubtedly a useful toolkit to help settle the controversy surrounding the effects and mechanisms of TCM therapies.…”
In China, traditional Chinese medicine (TCM) has been widely used for coronavirus infectious disease 2019 (COVID‐19) prevention, treatment, and recovery and has played a part in the battle against the disease. A variety of TCM treatments have been recommended for different stages of COVID‐19. But, to the best of our knowledge, a comprehensive database for storing and organizing anti‐COVID TCM treatments is still lacking. Herein, we developed TCM2COVID, a manually curated resource of anti‐COVID TCM formulas, natural products (NPs), and herbs. The current version of TCM2COVID (1) documents over 280 TCM formulas (including over 300 herbs) with detailed clinical evidence and therapeutic mechanism information; (2) records over 80 NPs with detailed potential therapeutic mechanisms; and (3) launches a useful web server for querying, analyzing and visualizing documented formulas similar to those supplied by the user (formula similarity analysis). In summary, TCM2COVD provides a user‐friendly and practical platform for documenting, querying, and browsing anti‐COVID TCM treatments, and will help in the development and elucidation of the mechanisms of action of new anti‐COVID TCM therapies to support the fight against the COVID‐19 epidemic. TCM2COVID is freely available at
http://zhangy-lab.cn/tcm2covid/
.
“…To date, 21 systematic reviews have been identified that have similar findings to this current review ( Liu M. et al, 2020 ; Ang et al, 2020 ; Sun CY. et al, 2020 ; Xiong X. et al, 2020 ; Fan et al, 2020 ; Pang et al, 2020 ; Zeng et al, 2020 ; Zhou et al, 2020 ; Wang H. et al, 2021 ; Liu M. et al, 2021 ; Wang Q. et al, 2021 ; Du et al, 2021 ; Fan et al, 2021 ; Jiang et al, 2021 ; Li et al, 2021 ; Liang et al, 2021 ; Luo et al, 2021 ; Wu et al, 2021 ; Yan et al, 2021 ; Yin et al, 2021 ; Zhuang et al, 2021 ). The treatment of COVID-19 benefits from the rapid dissemination of evidence, providing data for the synthesizing of evidence disseminated was constantly complied by systematic reviewers, resulting in a large number of systematic reviews with overlapping evidence, each article updated with the inclusion of only one or two additional studies at the time of publication.…”
Background: Integrative herbal medicine has been reported to have beneficial effects in the treatment of coronavirus disease 2019 (COVID-19).Aim: To compile up-to-date evidence of the benefits and risks of herbal medicine for the treatment of COVID-19 symptoms.Methods: Eleven databases, including PubMed, Cochrane Register of Controlled Trials (CENTRAL), Embase, Allied and Complementary Medicine Database (AMED), Chinese National Knowledge Infrastructure Database (CNKI), Wanfang Database, and Chinese Science and Technique Journals Database (VIP), Research Information Service System (RISS), Korean Medical database (KMBase), Korean Association of Medical Journal database (KoreaMed), and OASIS database, were searched from 15 June, 2020, until 28 March 2022. Randomized controlled trials (RCTs), published in any language, reporting the efficacy and safety outcomes of herbal medicine in patients of all ages with a PCR-confirmed diagnosis of COVID-19 were included in this analysis. Data extraction and quality assessments were performed independently.Results: Random-effects meta-analyses showed evidence of favorable effects of treatment with herbal medicine when added to standard treatment, versus standard treatment alone, on the total effective rate (p = 0.0001), time to remission from fever (p < 0.00001), rate of remission from coughing (p < 0.0001), fatigue (p = 0.02), sputum production (p = 0.004), improvement of manifestations observed on chest computed tomography scans (p < 0.00001), incidence of progression to severe COVID-19 (p = 0.003), all-cause mortality (p = 0.003), time to a negative COVID-19 coronavirus test (p < 0.0001), and duration of hospital stay (p = 0.0003). There was no evidence of a difference between herbal medicine added to standard treatment, versus standard treatment alone, on the rate of remission from symptoms such as a fever, sore throat, nasal congestion and discharge, diarrhea, dry throat, chills, and the rate of conversion to a negative COVID-19 coronavirus test. Meta-analysis showed no evidence of a significant difference in adverse events between the two groups. There was an unclear risk of bias across the RCTs included in this analysis, indicating that most studies had methodological limitations.Conclusion: Current evidence suggests that herbal medicine added to standard treatment has potential benefits in the treatment of COVID-19 symptoms but the certainty of evidence was low.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
