Efficacy of intense pulsed light therapy in the treatment of facial acne vulgaris: Comparison of two different fluences

Patidar, Monika V; Deshmukh, Ashish; Khedkar, Maruti

doi:10.4103/0019-5154.190115

Cited by 16 publications

(11 citation statements)

References 31 publications

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“…They appear to target the pathogenetic factors of acne by reducing inflammatory acne lesions, decreasing sebaceous gland activity and inhibiting C. acnes . More recently, various lasers such as the 585 and 595 nm pulsed dye lasers, 532 KTP laser, 1450 nm diode laser, 1540 nm erbium glass laser, intense pulsed light and radiofrequency devices have been used for the treatment of inflammatory acne vulgaris, but are not very effective for comedonal lesions 67–69. They also have the advantage of improving post acne scars.…”

Section: Methodsmentioning

confidence: 99%

<p>Menopausal Acne – Challenges And Solutions</p>

Khunger¹,

Mehrotra²

2019

IJWH

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Although acne is a disease predominant in adolescence, it is being increasingly observed in adult life, including the menopausal period. The etiology of menopausal acne is multifactorial, with hormonal imbalance being the major culprit. There is a relative increase of androgens in the menopausal female that leads to clinical hyperandrogenism manifesting as acne, hirsutism and androgenetic alopecia. Other endocrine disorders including thyroid abnormalities, hyperprolactinemia and insulin resistance also play a role. Genetics, stress, dietary changes, lack of sleep and exercise and other lifestyle changes are implicated as trigger factors. Most menopausal women with isolated few acne lesions have normoandrogenic serum levels and do not require extensive investigations. However, baseline investigations including total testosterone are useful. Patients must also be evaluated for associated comorbidities such as obesity, diabetes, hypertension and dyslipidemia. A detailed history can help to exclude polycystic ovarian syndrome, late-onset congenital adrenal hyperplasia or medications as a cause of acne. The evaluation of menopausal acne and the approach to treatment depend on the severity of acne and associated features. In patients with mild acne without virilization, prolonged topical therapy is the mainstay of treatment. Though combined oral contraceptives are effective, they are relatively contraindicated in the postmenopausal period. Spironolactone is the first choice of therapy in the subset of patients that require oral anti-androgen therapy. Procedural treatment can be useful as it can also help in the treatment of associated acne scars and concomitant skin aging. It is also important to focus on lifestyle changes such as reducing stress, controlling obesity, having a healthy diet, exercise and proper skin care routine to reduce acne. The focus of this article is on the clinical presentation and management challenges of menopausal acne, which represents a special subtype of acne.

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Section: Methodsmentioning

confidence: 99%

<p>Menopausal Acne – Challenges And Solutions</p>

Khunger¹,

Mehrotra²

2019

IJWH

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“…Crusting, bulla formation and hyperpigmentation were observed in four, one and two patients respectively but these resolved within 1 to 2 weeks. Patidar MV et al 11 reported itching in forty patients, erythema in two patients, burning sensation in three patients and two patients developed milia.…”

Section: Discussionmentioning

confidence: 99%

“…10 IPL in acne vulgaris works by photochemical, photothermal and photo-immunological process. 11,12 The photochemical reaction seen in acne vulgaris lesions is through its action on porphyrins produced by the P. acnes bacteria themselves.…”

Section: Discussionmentioning

confidence: 99%

Normative data of median nerve conduction in the state of Haryana

2020

IJN

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Introduction: Acne vulgaris is a self-limiting, chronic inflammatory disorder of pilosebaceous follicle seen commonly among young adults with significant psychological and social impact. Multiple topical and systemic therapies targeting various pathogenic factors of acne are available, in spite of which patients are unable to achieve adequate and long term control of acne. Therefore, there is a need for newer therapeutic modalities that are more effective, convenient and safe. In this regard, one of the emerging treatment modalities is intense pulse light (IPL) therapy which meet the need for novel acne treatment. Objectives: To evaluate the efficacy and safety of intense pulse light (IPL) therapy in the treatment of facial acne vulgaris. Materials and Methods: A total of 30 patients in age group of 18-40 years with facial acne vulgaris meeting the defined inclusion and exclusion criteria were enrolled in this study after taking an informed consent and approval of institutional ethical committee. All the patients with facial acne vulgaris grade 1-4 were subjected to monotherapy with IPL. Convention fluence of 10 J and 410 nm cut off filter was used at first sitting. IPL was administered weekly for 6 weeks, and the fluence was increased by 1 J every session. Acne severity assessment was done at initial visit (week 0) and at the end of last treatment session (week 6) based on Michaelssons acne severity index. Also at the initial visit, at each sitting and at the end of final treatment session (6 sessions), lesions count (counting the number of comedones, papules, pustules, cysts and nodules) were undertaken. Percentage reduction in the number of lesions were calculated at each visit and at end of final treatment session (6th session) and graded as mild (0-25%), moderate (26-50%), good (51-75%), and excellent (76-100%) improvement relative to baseline. Results: At the end of 6 treatment sessions (6 weeks), the mean percentage reduction of non-inflammatory, inflammatory and total lesion counts were 60.2%, 80.4%, 74.1% relative to baseline respectively. Mean Michaelssons acne severity index at baseline (0 week) was 50.83 and at the end of six treatment sessions was 10.20. The improvement in acne severity score was found to be statistically significant (p=.000). No significant adverse effects were noticed. Conclusion:The results of this study show that IPL is effective and safe for management of facial acne vulgaris grade 1 -4 with minimal reversible side effects.

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“…Other medications frequently used for treating acne included retinoids, traditional Chinese medicine (TCM) and benzoyl peroxide (BPO). The new treatments included intense pulsed light (IPL), blue and red light, photodynamic therapy (PDT), radiofrequency (RF) and alpha hydroxy acid (AHA) 19–23…”

Section: Introductionmentioning

confidence: 99%

Antibiotic susceptibility ofPropionibacterium acnesisolated from patients with acne in a public hospital in Southwest China: prospective cross-sectional study

Zhu

Qisa

et al. 2019

BMJ Open

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ObjectiveAntibiotics have been routinely used for several decades againstPropionibacterium acnes(P. acnes), but antibiotic resistance ofP. acnesis becoming a global problem. Only one related Chinese study is available. The aim of this study was to assess the antibiotic susceptibility ofP. acnesobtained from patients with acne in Southwest China.DesignThis was a prospective cross-sectional study. Cutaneous samples were obtained from acne lesions on the face of 375 patients. Samples were cultured in anaerobic medium to identify the presence ofP. acnes. Susceptibility tests of isolatedP. acneswere performed for tetracycline, doxycycline, clindamycin, erythromycin, azithromycin and clarithromycin using the Epsilometer test.ResultsP. acneswas isolated from 227 patients; 224 isolates (98.7%) were susceptible to doxycycline and 220 (96.9%) were susceptible to tetracycline, followed by clindamycin and clarithromycin in 101 (44.5%) and 102 (44.93%) isolates, respectively. Susceptibility ofP. acneswas detected for erythromycin in 96 (42.3%) patients, followed by azithromycin in 94 (41.4%). Subjects who received antibiotics (topical and oral) had higher frequencies of antibiotic-resistantP. acnesas well as increased antibiotic minimum inhibitory concentrations compared with patients without antibiotic treatment.ConclusionsP. acneswas highly sensitive to cyclines (doxycycline and tetracycline).P. acnesshowed higher resistance rates to macrolides–lincosamides–streptogramins antibiotics (such as erythromycin, azithromycin, clarithromycin and clindamycin). The irrational use of antibiotics for acne treatment is probably a problem in China and elsewhere. These results suggest that dermatologists should be more prudent in prescribing antibiotics for acne.

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Efficacy of intense pulsed light therapy in the treatment of facial acne vulgaris: Comparison of two different fluences

Cited by 16 publications

References 31 publications

<p>Menopausal Acne – Challenges And Solutions</p>

<p>Menopausal Acne – Challenges And Solutions</p>

Normative data of median nerve conduction in the state of Haryana

Antibiotic susceptibility ofPropionibacterium acnesisolated from patients with acne in a public hospital in Southwest China: prospective cross-sectional study

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