Efficacy of intensive multitherapy for patients with type 2 diabetes mellitus: a randomized controlled trial

Ménard, Julie

doi:10.1503/cmaj.050054

Cited by 51 publications

(23 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[34][35][36] Unfortunately, these goals have proven difficult to achieve in real-life settings. 37 Our findings support the importance of finding viable ways to increase the use of multiple drugs to treat patients with diabetes.…”

Section: Discussionsupporting

confidence: 73%

Predictors of Sustained Walking among Diabetes Patients in Managed Care: The Translating Research into Action for Diabetes (TRIAD) Study

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 73%

Predictors of Sustained Walking among Diabetes Patients in Managed Care: The Translating Research into Action for Diabetes (TRIAD) Study

et al. 2008

View full text Add to dashboard Cite

show abstract

“…This indicates that the intensive therapy can better improve the QoL of type 2 diabetes patients, in agreement with previous reports. 15 In view of the fact that the intensive therapy only had more frequent followup visits than the conventional therapy group, our findings also indicate that frequent follow-up visits can improve QoL of type 2 diabetes patients receiving oral hypoglycemic treatment.…”

Section: Discussionmentioning

confidence: 52%

Effects of Frequency of Follow-Up on Quality of Life of Type 2 Diabetes Patients on Oral Hypoglycemics

Zhou

Zeng

et al. 2012

Diabetes Technology & Therapeutics

View full text Add to dashboard Cite

Background: Poor quality of life (QoL) in diabetes patients is reportedly associated with adverse outcomes. In the present study, we assessed the effects of frequency of follow-up on clinical indicators as well as QoL of type 2 diabetes patients taking hypoglycemic agents. Subjects and Methods: In total, 155 type 2 diabetes patients were randomly assigned to two groups, which only differed in the frequency of follow-up visits. In both therapy groups, the patients were taking oral hypoglycemic agents. QoL was measured with a QoL Scale for Diabetes Mellitus (DMQLS) at study entry and months 3, 6, 9, and 12. Based on the drugs used, the patients were divided in three medication groups: glimepiride group, metformin group, and glimepiride + metformin group. Results: Repeated-measures analysis of variance revealed that compared with the conventional therapy group, the intensive therapy group showed significant improvement in the Disease, Psychology, and Satisfaction domain scores of the DMQLS, the overall DMQLS score, and clinical indicator values (fasting blood glucose, 2-h postprandial blood glucose, and glycosylated hemoglobin). Correlation analyses showed that the changes in Disease, Physiology, Psychology, and Satisfaction domain scores of the DMQLS and in the overall DMQLS score were negatively correlated with changes in clinical indicator values. Conclusions: Intensive frequency of follow-up is associated with improved QOL and clinical indicators and thus may be a preferred approach for type 2 diabetes patients on oral hypoglycemic agents. As QoL is negatively correlated with clinical indicators, it could be used as a comprehensive indicator of therapeutic effects on type 2 diabetes patients.

show abstract

“…Although exercise and increased physical activity are considered a cornerstone of T2D treatment (Canadian Diabetes Association Clinical Practice Guidelines Expert Committee 2008; Zinman et al 2004), given their key role in preventing and treating both insulin resistance (Seibaek et al 2003) and cardiovascular disease (Tanasescu et al 2003;Batty et al 2002), more people with T2D report a sedentary lifestyle than do nondiabetics (Morrato et al 2007;Nelson et al 2002). Furthermore, persons with T2D have demonstrated poor long-term adherence to exercise programs (Hanefeld et al 1991;Ménard et al 2005). This may suggest the existence of exercise barriers specific to T2D.…”

mentioning

confidence: 99%

Women with type 2 diabetes perceive harder effort during exercise than nondiabetic women

Huebschmann

Reis

Emsermann

et al. 2009

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

Regular exercise is a cornerstone of diabetes treatment; however, people with type 2 diabetes (T2D) are commonly sedentary. It is possible that a harder rate of perceived exertion (RPE) during exercise for those with T2D as compared with nondiabetics may be a barrier to physical activity. This study examined RPE (Borg scale, ordinal range 6-20) during submaximal exercise at identical absolute work rates to test the hypothesis that women with T2D demonstrate harder RPE during exercise than nondiabetic controls. In a prespecified analysis of existing data from equivalently sedentary women, RPE during submaximal exercise was compared among women with uncomplicated T2D (n = 13, mean body mass index (BMI) 34.2, mean hemoglobin A1c 9%), overweight controls (OC, n = 13, mean BMI 30.7), and normal-weight controls (NWC, n = 13, mean BMI 23.1). Subjects performed three 7 min, constant-load exercise tests at 20 W and 30 W. Mixed-effects general linear modeling was used to test for differences in mean RPE estimates among groups with and without adjustment for relative work intensity, age, habitual physical activity, or BMI. Subjects with T2D perceived harder effort during bicycling exercise than controls, as measured by RPE at 20 W and 30 W (p < 0.05 for T2D vs. OC and for T2D vs. NWC). Adjusting for relative work intensity eliminated significant group RPE differences at 30 W, but group RPE differences at 20 W remained significant. Harder perceived effort during exercise may be a barrier to physical activity for those with T2D.

show abstract

Efficacy of intensive multitherapy for patients with type 2 diabetes mellitus: a randomized controlled trial

Cited by 51 publications

References 29 publications

Predictors of Sustained Walking among Diabetes Patients in Managed Care: The Translating Research into Action for Diabetes (TRIAD) Study

Predictors of Sustained Walking among Diabetes Patients in Managed Care: The Translating Research into Action for Diabetes (TRIAD) Study

Effects of Frequency of Follow-Up on Quality of Life of Type 2 Diabetes Patients on Oral Hypoglycemics

Women with type 2 diabetes perceive harder effort during exercise than nondiabetic women

Contact Info

Product

Resources

About