Efficacy of interferon‐α2b treatment in children with chronic hepatitis B who have previously undergone therapy for cancer

Abstract

In conclusion, a 12 month course of IFN-alpha2b induces some beneficial effects on virologic, biochemical and histologic indices in children with chronic hepatitis B who have previously undergone therapy for cancer.

Five‐year results of chronic hepatitis B infection treatment in children with cured cancer

“…In a study from Turkey, 11.6% of children surviving malignancy had positive hepatitis B surface antigen (HBsAg) (1). Interferon (IFN) alone (6 or 12 months) or prednisone with IFN‐α and famciclovir were used for treatment of chronic hepatitis B (CHB) infection and response to treatment was observed in approximately 25% of these children (2–4). Kocak et al (2) reported that complete response, defined as clearance of both HBV DNA and hepatitis B e antigen (HBeAg) and seroconversion to anti‐HBe was observed in two (25%) out of eight patients.…”

“…Kocak et al (2) reported that complete response, defined as clearance of both HBV DNA and hepatitis B e antigen (HBeAg) and seroconversion to anti‐HBe was observed in two (25%) out of eight patients. Kasirga et al (3) reported that three (27.3%) out of 11 patients had seroconversion to anti‐HBe. Long‐term results of treatment were not reported in these studies.…”