2020
DOI: 10.1016/j.jvs.2019.03.081
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Efficacy of intra-arterial catheter-directed thrombolysis for popliteal and infrapopliteal acute limb ischemia

Abstract: Objective: The purpose of this study was to examine the efficacy and safety of catheter-directed thrombolysis (CDT) for first-line treatment of popliteal and infrapopliteal acute limb ischemia. Methods: A total of 28 consecutive patients (30 limbs) who underwent CDT for treatment of popliteal and infrapopliteal acute limb ischemia of thromboembolic origin between March 2012 and December 2017 were enrolled in this study. Per the Society for Vascular Surgery, limbs were classified into three runoff score groups:… Show more

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Cited by 13 publications
(11 citation statements)
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“…ALI is caused by a sudden interruption of the main blood perfusion of the lower limb for various reasons, and it usually requires immediate revascularization. CDT has become one of the most commonly used methods for the treatment of ALI 11,12 . After thrombolytic therapy, the vascular stenosis, occlusion and other lesions can be treated simultaneously with interventional therapy, which improves the short-term and long-term patency rate of such occlusive lesions and reduces the need for open surgery in most of these patients 4 .…”
Section: Discussionmentioning
confidence: 99%
“…ALI is caused by a sudden interruption of the main blood perfusion of the lower limb for various reasons, and it usually requires immediate revascularization. CDT has become one of the most commonly used methods for the treatment of ALI 11,12 . After thrombolytic therapy, the vascular stenosis, occlusion and other lesions can be treated simultaneously with interventional therapy, which improves the short-term and long-term patency rate of such occlusive lesions and reduces the need for open surgery in most of these patients 4 .…”
Section: Discussionmentioning
confidence: 99%
“…ALI is caused by a sudden interruption of the main blood perfusion of the lower limb for various reasons, and it usually requires immediate revascularization. CDT has become one of the most commonly used methods for the treatment of ALI 12 , 13 . After thrombolytic therapy, the vascular stenosis, occlusion and other lesions can be treated simultaneously with interventional therapy, which improves the short-term and long-term patency rate of such occlusive lesions and reduces the need for open surgery in most of these patients 4 .…”
Section: Discussionmentioning
confidence: 99%
“…Technical success of the primary procedure was defined as complete in situ thrombus clearance of CBT or CDT alone, and adjunctive treatment of CDT to achieve thrombus clearance for CBT was considered to indicate assistant technical success. Clinical success (improvement in clinical status) was defined as the absence and/or relief of symptoms related to ALI according to accepted guidelines [ 5 , 11 ], or an improvement in the Rutherford grade of at least one category with objective evidence of hemodynamic change (at least 0.1 increase in ABI). Limb salvage was defined as freedom from major amputation (performed above the ankle), and maintained functional autonomy (walking or standing) was determined in accordance to accepted guidelines [ 5 ].…”
Section: Methodsmentioning
confidence: 99%
“…For endovascular approaches, conventional catheter-directed thrombolysis (CDT) is one of the most well established and employed techniques [ 10 , 11 ]. Recently, a variety of new endovascular modalities aimed at mechanical disruption of the thrombus have emerged, and catheter-based thrombectomy (CBT) techniques, including thromboaspiration, microfragmentation, pharmacomechanical thrombectomy and ultrasound-accelerated CDT, have emerged and been made more available [ 12 ].…”
Section: Introductionmentioning
confidence: 99%