Efficacy of Intra-Articular Injection of Platelet-Rich Plasma Combined with Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Zeng, Weipeng; Wang, Gongze; Liao, Xinping; Pei, Caifeng

doi:10.1155/2022/2192474

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…Various nonoperative treatments for knee osteoarthritis were evaluated in the last year. An RCT comparing the efficacy of a single intra-articular injection of platelet-rich plasma combined with 2 different hyaluronans (platelet-rich plasma and hyaluronan #1 compared with platelet-rich plasma and hyaluronan #2) for the treatment of Kellgren-Lawrence grade-2 knee osteoarthritis showed significant improvements in pain reduction (change in visual analog scale [VAS] pain score from baseline to 6 months after the injections) for both groups 4 , whereas a systematic review and meta-analysis evaluating the efficacy of intra-articular platelet-rich plasma combined with mesenchymal stem cells also revealed that such a combination significantly reduces knee pain 5 . However, none of these studies included a placebo control group.…”

Section: Osteoarthritis Of the Kneementioning

confidence: 99%

What’s New in Adult Reconstructive Knee Surgery

Villa,

Hosseinzadeh,

Higuera-Rueda

2023

Journal of Bone and Joint Surgery

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In the current Guest Editorial, we evaluate and summarize the most relevant findings from recent, meaningful, peer-reviewed publications in different research areas. Articles at various Levels of Evidence were included, but increased attention was paid to Level-I and award-winning reports. EconomicsConsiderable debate continues with regard to the economics of reconstructive knee surgery. An updated Medicare projection revealed that, by 2040, the annual number of revision total knee arthroplasties (TKAs) performed would be 115,147, whereas, by 2060, it would be 286,740. These values are important for understanding the future health-care resource utilization involving revision TKA, which is only expected to increase 1 . A secondary analysis of a randomized clinical trial (RCT) evaluating health-care resource utilization up to 12 months after primary TKA, among dissatisfied and satisfied patients, showed that patients dissatisfied with their return to function incurred a mean cost of $19,007.70, compared with $13,523.83 for satisfied patients (p = 0.07). Although the cost difference was not significant, its magnitude deserves attention 2 . Data from the New Zealand Joint Registry indicated that patients undergoing TKA have a mortality rate 8% higher than that of the general population 3 . Assessing mortality after primary TKA is relevant for future economic analyses.

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Section: Osteoarthritis Of the Kneementioning

confidence: 99%

What’s New in Adult Reconstructive Knee Surgery

Villa,

Hosseinzadeh,

Higuera-Rueda

2023

Journal of Bone and Joint Surgery

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“…The intricate microenvironment within the joint space affected by OA plays a crucial role in propelling the advancement of the disease [6,7].…”

Section: Introductionmentioning

confidence: 99%

Nanozyme-Enhanced Injectable Hydrogel for the Treatment of Osteoarthritis

Wang,

Li,

Liu

et al. 2024

Preprint

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The tissue pathological changes of osteoarthritis (OA) encompass degenerative alterations in articular cartilage, peripheral bone proliferation, and synovial inflammation. The progression of OA is dramatically accelerated by the reactive oxygen species (ROS)-induced apoptosis of chondrocytes and the inflammatory response of synovial macrophages. The bone joint microenvironment refers to the biological environment inside the bone joints, which impacts the survival and function of cells within the bone joints. The interaction between the imbalance of the microenvironment and excessive generation of ROS promotes the development of arthritis. To address this issue, we have developed an injectable hydrogel with catalase-mimic nanozyme activity as a therapeutic agent for OA. The prepared nanozyme-reinforced hydrogels capable of not only eliminating ROS and inflammatory cytokines but also inducing the transformation of M1 macrophages into M2 phenotype in the harsh microenvironment. The dual mechanism enhances the repair of cartilage and facilitates the reduction of osteophyte formation in OA by improving the microenvironment within the joints. Our research has introduced an innovative treatment strategy for the clinical management of OA, demonstrating significant potential for its application in treating OA.

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“…Due to its high prevalence, Knee OA has already become one of the neurosurgeons' primary areas of interest. While the most frequently used conservative treatments for Knee OA are medications such as (HA), and steroids, the effectiveness of these treatments is far from acceptable (Zeng et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma treatment for knee osteoarthritis: A systematic investigation

Gangadharan,

Satapathy,

Dixit

et al. 2024

Multidiscip. Rev.

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According to indicates, “platelet-rich plasma (PRP)” is efficient, including secure biological technique for handling knee “osteoarthritis (OA)." Considering the number of injections necessary to see the beneficial impact, however, an agreement has yet to be reached. The therapeutic effectiveness of a single PRP injection versus numerous injections in "randomized controlled trials (RCTs)" for OA knee. To examine the impact of single vs. many treatments of PRP for suffering and functioning in patients with knee OA, extensive searching was done for RCTs published between 1970 and 2019. The information systems “MEDLINE, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials” were searched. Data on patients, interventions, comparisons, and meaningful outcomes were collected using a data extraction tool to contain research bibliographic material. The statistics regarding the immediate results were combined using a random effects framework. With a low-moderate risk of bias and 301 patient reports, we considered clinical studies. Six months following the treatment, a synthesis revealed no substantial variations between solo and repeated injections about suffering relief standardized, average variance. The effectiveness of the knee significantly improved after numerous injections. The considerable boost was only discernible for the outcomes of solo vs. multiple pills, according to a sub-analysis. Our findings showed that a single PRP injection was just as successful in reducing inflammation as numerous treatments. However, after six months, several therapies appeared more beneficial than a single injection in improving joint functioning. The available data still needs to be improved, and further study on this subject is necessary to support our findings.

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Efficacy of Intra-Articular Injection of Platelet-Rich Plasma Combined with Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 27 publications

What’s New in Adult Reconstructive Knee Surgery

What’s New in Adult Reconstructive Knee Surgery

Nanozyme-Enhanced Injectable Hydrogel for the Treatment of Osteoarthritis

Platelet-rich plasma treatment for knee osteoarthritis: A systematic investigation

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