Efficacy of intralesional photodynamic therapy for the treatment of hidradenitis suppurativa

Rodríguez-Prieto, Manuel Ángel; Valladares-Narganes, Luis Miguel; González‐Sixto, B.; Noguerol-Cal, María

doi:10.1016/j.jaad.2012.11.030

Cited by 21 publications

(22 citation statements)

References 5 publications

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“…Recently, laser light has been delivered by fiber-optic probe intraluminally into sinuses irrigated with photosensitizer in solution. The preliminary results are positive [47].…”

Section: Photodynamic Therapymentioning

confidence: 89%

Hidradenitis suppurativa

Margesson

Danby

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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Hidradenitis suppurativa is a chronic relapsing disorder of the folliculopilosebaceous units (FPSUs). Its negative impact on quality of life is extreme, mainly due to the lack of early recognition, accurate diagnosis, and appropriate management. The support structure of the FPSUs is defective. Under the influence of endogenous reproductive hormones, exogenous hormones, androgens and their precursors in dairy products, and other dietary factors, the follicular unit is plugged and distended by retained keratin. Friction, shearing forces, and pressure lead to rupture and leakage of the ductal contents from the weakened FPSU, causing an inflammatory reaction mediated mainly by the innate immune system. Therapy requires patient comprehension and cooperation, counseling, aggressive hormonal and dietary modification, avoidance of the trauma that leads to rupture, active multimodal anti-inflammatory therapy, and early unroofing and debridement. The full therapeutic program is needed to avoid the aggressive surgery required if the condition is not diagnosed early and managed appropriately.

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“…Recently, laser light has been delivered by fiber-optic probe intraluminally into sinuses irrigated with photosensitizer in solution. The preliminary results are positive [47].…”

Section: Photodynamic Therapymentioning

confidence: 89%

Hidradenitis suppurativa

Margesson

Danby

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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“…In these cases, treatments were more tolerable for subjects treated with blue light than with intense pulsed light. Uncertain results have been obtained with intralesional PDT [74][75] . Agut-Busquet et al [76] recently reported a retrospective experience in the treatment of HS with PDT using intralesional methylene blue and a 635-nm light-emitting diode lamp in 7 patients.…”

Section: Hidradenitis Suppurativamentioning

confidence: 99%

“…A significant reduction in the Hidradenitis Suppurativa Lesion, Area and Severity Index (HS-LASI) after treatment was elicited in both groups, with no pain, erythema, or hyperpigmentation. The most recent and up-to-date review on PDT treatment for HS, analyzing studies and case series on 64 patients, suggest that MAL-PDT or intralesional ALA-PDT may be the best PDT modalities to treat HS, acting as an adjuvant to therapies such as clindamycin and rifampicin [74] . Greater absorption of ALA together with higher production of protoporphyrin IX in hair follicles compared to other tissues has been suggested as the mechanism of action of PDT for HS [70] .…”

Section: Hidradenitis Suppurativamentioning

confidence: 99%

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Photodynamic Therapy and Skin Appendage Disorders: A Review

Megna

Fabbrocini

Marasca

et al. 2016

Skin Appendage Disord

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Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. The present review summarizes published data on PDT application in skin appendage disorders. Our literature review shows that: (a) PDT may be a suitable treatment for acne, folliculitis decalvans, hidradenitis suppurativa, nail diseases, and sebaceous hyperplasia; (b) there is a lack of agreement on PDT features (type, concentrations and incubation period of used substances, number and frequency of PDT sessions, optimal parameters of light sources, and patient characteristics [e.g., failure to previous treatments, disease severity, body surface area involved, etc.] which should guide PDT use in these diseases); (c) further research is needed to establish international guidelines helping dermatologists to choose PDT for the right patient at the right time.

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“…Recently, RodriguezPrieto et al used intralesional PDT for the treatment of HS and showed good e®ect. 16,17 Intralesional PDT will be a good choice for late sinus/¯stula lesions. Saraceno et al reported a case of HS achieved 80% remission of skin lesions treated by nine times of Methyl aminolaevulinate PDT.…”

Section: Discussionmentioning

confidence: 99%

Topical 5-aminolevulinic acid photodynamic therapy improved refractory acne conglobata and perifolliculitis capitis abscedens et suffodiens rather than hidradenitis suppurativa

Zhang

Wang

Shi

et al. 2016

J. Innov. Opt. Health Sci.

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Acne conglobata (AC), perifolliculitis capitis abscedens et su®odiens (PCAS) and hidradenitis suppurativa (HS) are uncommon refractory chronic, in°ammatory, scarring diseases but cause serious damage to the quality of life. These three diseases are associated with follicular occlusion. Several studies indicated topical 5-aminolevulinic acid photodynamic therapy (ALA-PDT) improved follicular occlusion besides acne treatment. So we attempted to apply ALA-PDT to medicine resistant AC, PCAS and HS. Topical ALA-PDT was applied to 10 patients with AC, seven patients with PCAS and three patients with HS for more than three sessions. All the patients completed the dermatology life quality index (DLQI) questionnaire and were assessed for the e±cacy at the baseline and on two weeks after each treatment. Adverse e®ects were recorded at each visit. The results showed 25.5% (5/20, two cases of AC and three cases of PCAS) of patients achieved excellent improvement after three sessions of PDT and another 60. HS) got poor response (< 20% lesions clearance). Another¯ve cases (three cases of AC and two cases of PCAS) also achieved excellent response after 5-7 sessions of PDT. We also found that papular/nodular, cyst/abscess showed higher clearance rate than sinus/¯stula (88.5%, 86.1% versus 11.1%). DLQI was reduced after three sessions of PDT in AC and PCAS patients rather than HS patients. 5-ALA-PDT could improve refractory AC and PCAS but could not lead to improvement in late stage of HS. The e±cacy increased with more treatment sessions.

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Efficacy of intralesional photodynamic therapy for the treatment of hidradenitis suppurativa

Cited by 21 publications

References 5 publications

Hidradenitis suppurativa

Hidradenitis suppurativa

Photodynamic Therapy and Skin Appendage Disorders: A Review

Topical 5-aminolevulinic acid photodynamic therapy improved refractory acne conglobata and perifolliculitis capitis abscedens et suffodiens rather than hidradenitis suppurativa

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