Efficacy Of Intraoperative Methadone And Clonidine In Pain Control In The Immediate Postoperative Period After The Use Of Remifentanil

Abstract

Methadone was more effective than clonidine in the control of postoperative pain in videolaparoscopic surgeries under total intravenous anesthesia with remifentanil; and using clonidine was not better than not using it.

A randomised double blind clinical trial to compare surgical field bleeding during endoscopic sinus surgery with clonidine-based or remifentanil-based hypotensive anaesthesia

“…Previous studies have reported differences between hypotensive anaesthesia based either on opioid antagonists like fentanyl or remifentanil, or on central acting agents like clonidine (19)(20)(21) . have a more favourable pharmacological profile, which offers better, more controlled haemodynamic management, with an optimized hypotensive effect during anaesthesia that allows safe bleeding control (28)(29)(30)(31) . In our previous observational cohort pilot study, we recorded a trend towards a better haemodynamic profile and heart rate estimates, lower bleeding scores and reduced surgery duration with clonidine as compared to an opioid-based regimen (22) .…”

Effect of Perioperative Systemic α2 Agonists on Postoperative Morphine Consumption and Pain Intensity

“…Recovery Times. Time to extubation was reported in five trials, 16,20,30,39,40 time to spontaneous eye opening in four, 25,30,36,39 and time to response to verbal command in nine ( 16,19,25,28,30,34,35,39,40 In dexmedetomidine trials, the median of all average times to extubation in control subjects was 7.0 min (range, 5.7-7.5). Dexmedetomidine significantly shortened that time (WMD Ϫ1.6 min).…”

Revisiting methadone: pharmacokinetics, pharmacodynamics and clinical indication

“…At this moment, it is indicated the use of long-lasting opioids. The methadone is an effective alternative to conventional opioids to control postoperative pain 38,44,[51][52][53][54][55] .…”