Efficacy of Intratympanic Corticosteroid as a Salvage Treatment in Idiopathic Sudden Sensorineural Hearing Loss

Amarillo, Elizabeth; Hernando, Mónica; Eisenberg, Gustavo; Granda, Mónica; Plaza, Guillermo

doi:10.1016/j.otoeng.2018.04.006

Cited by 3 publications

(6 citation statements)

References 31 publications

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“…These studies were obtained in full and read for final eligibility. Eleven studies were finally included, which comprised of four randomized controlled trials (Lee et al, 2011;Li et al, 2011;Wu et al, 2011;Xenellis et al, 2006) and seven observational studies (Ahn et al, 2008;Amarillo et al, 2019;Clary et al, 2011;Covelli et al, 2018;Erdur et al, 2014;Moon et al, 2011;Morita et al, 2016). A flowchart showing the selection of studies can be seen in Figure 1 and an overview of the included studies is found in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…The objective of this systematic review was to provide an overview and quality assessment of the current evidence regarding ITC as salvage treatment for ISSNHL. Following a systematic search for literature, we identified four randomized controlled trials (Lee et al, 2011;Li et al, 2011;Wu et al, 2011;Xenellis et al, 2006) and seven observational studies (Ahn et al, 2008;Amarillo et al, 2019;Covelli et al, 2018;Erdur et al, 2014;Clary et al, 2011;Moon et al, 2011;Morita et al, 2016) that matched our inclusion criteria. The meta-analysis of both the randomized controlled trials and observational studies showed a statistically significant increase in the number of patients obtaining recovery in favor of ITC as salvage treatment for patients with ISSNHL.ITC treatment for Meniere's disease, autoimmune inner ear disease, and ISSNHL was pioneered over 25 years ago (Silverstein et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

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Intratympanic corticosteroid as salvage therapy in treatment of idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis

Devantier

Edemann-Callesen²,

Jensen³

et al. 2022

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intratympanic corticosteroid as salvage therapy in treatment of idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis

Devantier

Edemann-Callesen²,

Jensen³

et al. 2022

Heliyon

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“…In this sense, in recent years there has been an increase in the number of publications dealing with corticosteroids [59], intratympanic injections [60] and hyperbaric oxygen therapy [25,26]. These studies demonstrate the efficacy against sudden deafness, either in combination therapy [61] or individually [62][63][64], reaching the conclusion that early and successful treatment obtains very favorable results [6,7].…”

Section: Signing Authorsmentioning

confidence: 99%

“…Approximately half of people with SSNHL can recover part or all of their hearing spontaneously or within one or two weeks from the onset of symptoms (65%) [4], although the lower the hearing loss, the better the prognosis, Even so, delaying the diagnosis and treatment can decrease the recovery of the hearing [5]. Receiving treatment in a timely manner greatly increases the chances of recovering at least part of the hearing [6][7].…”

Section: Introductionmentioning

confidence: 99%

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Trends in the Scientific Literature on Sudden Hearing Loss: A Bibliometric Study

Clarós¹

2020

JCO

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Objective: To analyze the scientific publications, from a bibliometric approach, on the sudden hearing loss since the first documents appear (1966) until the year 2017. Methods: The Scopus database was used to carry out the study, and the descriptors "sudden hearing loss", “sudden sensorineural hearing loss" and "sudden sensorial hearing loss" were used, limited to the title, keywords and summary field. The most common bibliometric indicators were applied for the selected publications. Results: A total of 2,509 original articles were recovered between1966-2017. The growth of the publications was adapting better to a linear adjustment (r = 0.84). The time of duplication is 10.4 years. Bradford's core (most productive journals) formed by thirteen journals, some of the most productive are Otology and Neurotology, Acta Oto-Laryngologica and Laryngoscope, with an Impact Factor of 2.024, 2.471 and 1.116, respectively. Regarding geographical distribution, the United States, Japan and Germany present the highest production. Conclusions: The scientific production on the sudden hearing loss follows a linear growth, without evidence that should have reached a saturation point. In this case, the postulates of the Law of growth of Price's science are not fulfilled. In addition, a high index of transience exists.

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Efficacy of intratympanic or postauricular subperiosteal corticosteroid injection combined with systemic corticosteroid in the treatment of sudden sensorineural hearing loss: A prospective randomized study

et al. 2023

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ObjectivesThis study aimed to investigate the efficacy and safety of intratympanic or postauricular subperiosteal glucocorticoid injection combined with systemic glucocorticoid in the treatment of sudden sensorineural hearing loss (SSNHL).MethodsThis study is a prospective randomized controlled study. This study included unilateral SSNHL patients who were hospitalized in our department between January 2020 and June 2021. Patients were randomly divided into three groups (groups A, B, and C). Patients in group A were treated with an intratympanic corticosteroid injection combined with systemic corticosteroid treatment, and patients in group B received a postauricular corticosteroid injection combined with systemic corticosteroid treatment. Patients in group C (control group) were treated with systemic corticosteroid alone. The case number of groups A, B, and C was 311, 375, and 369, respectively.ResultsThere was no significant difference in gender distribution, the proportion of left and right affected ears, and the average interval from onset to treatment among the three groups (P > 0.05). However, there were significant differences in their average age, distribution of audiogram type, and hearing loss levels among them (P < 0.01). Our study shows that there was no significant difference in average hearing threshold improvement before and after treatment in the three groups (P > 0.05). Regarding the complications, in group A, 33 patients (10.6%) had a transient vertigo attack during tympanic injection, which lasted for ~1–3 min. In group B, 20 patients (6.43%) complained of pain at the injection site, which disappeared after 1–3 days. No other complications occurred in all the other patients.ConclusionThe addition of intratympanic or postauricular corticosteroid to systemic steroids did not result in a significant effect on hearing recovery in SSNHL. No obvious complications occur in SSNHL patients treated with intratympanic injection or postauricular injection of corticosteroid.Clinical trial registration[chictr.org.cn], registration number: ChiCTR2100048762.

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Efficacy of Intratympanic Corticosteroid as a Salvage Treatment in Idiopathic Sudden Sensorineural Hearing Loss

Cited by 3 publications

References 31 publications

Intratympanic corticosteroid as salvage therapy in treatment of idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis

Intratympanic corticosteroid as salvage therapy in treatment of idiopathic sudden sensorineural hearing loss: A systematic review and meta-analysis

Trends in the Scientific Literature on Sudden Hearing Loss: A Bibliometric Study

Efficacy of intratympanic or postauricular subperiosteal corticosteroid injection combined with systemic corticosteroid in the treatment of sudden sensorineural hearing loss: A prospective randomized study

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