Efficacy of Intravenous Lignocaine Versus Topical Lignocaine in Attenuation of Haemodynamic Surge During Laryngoscopy and Intubation in Patients Undergoing Surgery Under Generalanaesthesia - A Single Blind Randomized Control Study

Abstract

The present study was undertaken to evaluate the efcacy of intravenous lignocaine versus topical lignocaine for attenuating haemodynamic response during laryngoscopy and intubation in patients undergoing surgery under general anaesthesia. This single blind randomized control study was done on sixty patients of either sex aged between 18 to 55 years, of American Society of Anesthesiologists (ASA) status class I undergoing elective surgery under general anesthesia with endotracheal intubation. Patients were randomly allocated into two groups (group A and group B). Group A and Group B received intravenous preservative free lignocaine hydrochloride 2% 2 mg/kg and topical (nebulized) lignocaine hydrochloride 4% at 2mg/kg. Heart rate, systolic, diastolic and mean blood pressure was documented before administering premedication (T0), at time of intubation (TI) and 1 min (T-1), 2 min (T-2) & 5 min (T- 5) after intubation. Attenuation in the HR , SBP, DBP, MBPwere found statistically signicant (P<0.05) in group B in comparison to the group A. So, to conclude, topical lignocaine 4% blunts haemodynamic response to laryngoscopy and intubation better than intravenous lignocaine 2% when other confounding factors are eliminated.