2019
DOI: 10.1080/1061186x.2019.1574802
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Efficacy of intravesical targeting of novel quorum sensing inhibitor nanoparticles againstPseudomonas aeruginosabiofilm-associated murine pyelonephritis

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Cited by 16 publications
(12 citation statements)
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“…100 In addition, chitosan NPs have a negative effect on the pathogenic factors produced by P. aeruginosa PAO1. 101 In this regard, Muslim et al, 100 in their study demonstrated that chitosan significantly decrease the biofilm formation, pyocyanin, protease secretion, as well as the expressions of lasR and rhlR genes in P. aeruginosa. In addition, Ilka et al reported that the loaded kaempferol into chitosan NPs have QSI activity and suggested that a combination of materials with chitosan NPs can inhibit the QS-related encoding genes, which can serve as a new approach for antibacterial treatment acting as the QS-based antibiofilm agents.…”
Section: Synthetic Compoundsmentioning
confidence: 98%
“…100 In addition, chitosan NPs have a negative effect on the pathogenic factors produced by P. aeruginosa PAO1. 101 In this regard, Muslim et al, 100 in their study demonstrated that chitosan significantly decrease the biofilm formation, pyocyanin, protease secretion, as well as the expressions of lasR and rhlR genes in P. aeruginosa. In addition, Ilka et al reported that the loaded kaempferol into chitosan NPs have QSI activity and suggested that a combination of materials with chitosan NPs can inhibit the QS-related encoding genes, which can serve as a new approach for antibacterial treatment acting as the QS-based antibiofilm agents.…”
Section: Synthetic Compoundsmentioning
confidence: 98%
“…However, the therapeutic applicability of ajoene is limited due to availability, instability, hydrophobicity and relatively high MIC values. Efforts are being undertaken to overcome these issues through modification, the use novel delivery systems and a targeted route of administration and through the development of synthetic ajoene analogues (Fong et al, 2017;Vadekeetil et al, 2019).…”
Section: Ajoenementioning
confidence: 99%
“…Due to undesirable cytotoxicity or low bioavailability, the quorum sensing inhibitors were loaded into polymeric NPs based on chitosan and dextran sulfate. In combination with antibiotic ciprofloxacin, these nanocarriers were able to target and reduce P. aeruginosa biofilm‐associated murine pyelonephritis in mice (Vadekeetil, Chhibber, & Harjai, 2019).…”
Section: Active Targeting Of Antimicrobial Nanomaterialsmentioning
confidence: 99%