Efficacy of iron-folic acid treatment for reducing anemia prevalence and improving iron status in women of reproductive age: A one-year longitudinal study

Palika, Ravindranadh; Dasi, Teena; Ghosh, Santu; Peter, Rajini; Parasannanavar, Devraj J.; Pradhan, Anju Sinha; Kurpad, Anura V; Sachdev, Harshpal Singh; Kulkarni, Bharati; Pullakhandam, Raghu

doi:10.1016/j.clnesp.2022.03.016

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…This analysis de ned the Hb response curve to increasing exposures of body iron status (PF or BIS, assuming that folate status was normalized and replete) from a longitudinal analysis of a highly supervised IFA treatment of 90 days, that tested the e cacy of a 'screen and treat' program to achieve anaemia reduction. 11,12 The motivation for the present analysis came from the nding that even though the IFA compliance was high (76%) in this captive study setting for 90 days, the supplementation could not mitigate anaemia completely among a mixed group of anaemic and non-anaemic WRA, in whom a signi cant proportion remained either mild (18.9%) or moderately (10.8%) anaemic. 11 This analysis was agnostic to the type of IFA supplementation, different as it was for anaemic and non-anaemic subjects due to ethical considerations for anaemia treatment/prevention norms, 13 and relied on the change in PF or BIS as the key exposure for Hb change.…”

Section: Discussionmentioning

confidence: 99%

“…The PF (# FR248T, Calbiotech, USA), sTfR(# DY2474, R&D systems, USA), hepcidin (#DY8307-05, R&D systems, USA) and C-reactive protein (# DY1707, R&D systems, USA) measurements were performed using their respective ELISA kits, following manufacturer instructions. 11 . The CV of these assays was always < 5%.…”

Section: Blood Analysesmentioning

confidence: 99%

“…A recent longitudinal intervention study in young, healthy Indian WRA offered such data for analysis, where sequential changes in venous blood Hb, iron store biomarkers like PF, soluble transferrin receptor (sTfR), BIS, and C-reactive protein (CRP) were measured during a 90-day IFA supplementation. 11…”

Section: Introductionmentioning

confidence: 99%

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Haemoglobin diagnostic cut-offs for anaemia in Indian women of reproductive age

et al. 2023

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BackgroundThe persistent high prevalence of anaemia among Indian women of reproductive age (WRA) despite aggressive long-term iron supplementation, could be related to over-diagnosis from an inappropriately high haemoglobin (Hb) diagnostic cut-off. To develop an appropriate cut-off for Indian WRA, we hypothesized that during iron-folic acid (IFA) supplementation to a mixed (anaemic/non-anaemic) WRA population, the positive slope of the Hb-plasma ferritin (PF) response in anaemic women would in ect into a plateau (zero-response) as a non-anaemic status is reached. The 2•5th percentile of the Hb distribution at this in ection point will be the diagnostic Hb cut-off for iron-responsive anaemia. MethodA hierarchical mixed effects model, with a polynomial mean and variance model to account for intraclass correlation due to repeated measures, was used to estimate the response curve of Hb to PF, or body iron stores (BIS), in anaemic and non-anaemic WRA (without in ammation), who were receiving a 90-day ironfolic acid (IFA) supplementation. ResultsThe Hb response curve at low PF values showed a steep increase, which in ected into a plateau at a PF of 10.1 µg/L. The Hb distribution at the in ection was a normal probability distribution, with mean of 12•3 g/dL. The 2•5th percentile value of this distribution, orthe putative diagnostic Hb cut-off for anaemia, was 10•8 g/dL. ConclusionThe derived Hb cut-off is lower than the current adult values of 12 g/dL and could partly explain the persistently high prevalence of iron de ciency and anaemia.

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Section: Discussionmentioning

confidence: 99%

Section: Blood Analysesmentioning

confidence: 99%

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Haemoglobin diagnostic cut-offs for anaemia in Indian women of reproductive age

et al. 2023

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“…The characteristic of the fast food pattern was a high intake of fast food, convenience food, beverages, and sweets, and it was positively associated with the level of anemia in our study. Anemia is closely related to nutrients such as iron [32], protein, vitamin B12, and folic acid [33,34]. About 80% of iron in the body is related to the production of hemoglobin in red blood cells [35,36]; thus, iron deficiency is regarded as the most common " means p-value < 0.05; "+"means p-value < 0.06.…”

Section: Discussionmentioning

confidence: 99%

Dietary Patterns and Association with Anemia in Children Aged 9–16 Years in Guangzhou, China: A Cross-Sectional Study

Ma,

Huang,

Zeng

et al. 2023

Nutrients

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Anemia affects 1.8 billion people worldwide, and diet is one of the key modifiable factors for treating anemia in children. The dietary pattern has changed rapidly in recent decades, but its effect on childhood anemia has not been reported. This study aimed to identify dietary patterns among children in rural areas of Guangzhou, China, and explore their association with anemia. A total of 1476 children aged 9–16 years old were included in this study. Demographics, lifestyle, and anthropometric and dietary information were collected. Factor analysis was used to identify dietary patterns, and anemia was diagnosed based on hemoglobin levels. Robust Poisson regression and subgroup analysis were used to analyze the association between dietary patterns and anemia. The prevalence of anemia in children was 10.4%, with 6.1% in boys and 15.4% in girls. Four dietary patterns were identified, including a fast food pattern, a vegetarian pattern, a meat and egg pattern, and a rice and wheat pattern. A high score in the fast food pattern was positively associated with risk of anemia in children entering puberty (PR = 1.767, 95% CI: 1.026~3.043, p = 0.039), especially in girls after menarche, with marginal significance (PR = 1.740, 95% CI: 0.977~3.097, p = 0.059). A high score in the meat and egg pattern was negatively associated with risk of anemia in children entering puberty (PR = 0.498, 95% CI: 0.286~0.866, p = 0.013), especially in boys after spermatorrhea (PR = 0.237, 95% CI: 0.031~0.590, p = 0.007). The fast food pattern was a risk factor for anemia in children, and the meat and egg pattern was a protective factor for anemia in children entering puberty. The findings of this study could be used to guide the strategies of evidence-based preventive nutrition interventions to curb anemia in children.

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“…Известно, что усвояемость железа улучшает фолиевая кислота [17]. В ряде исследований было установлено, что противоанемическое действие фармакологической комбинации железа и фолатов превосходит таковое при действии только монопрепаратами железа [18,19]. Фолиевая кислота влияет на биосинтез ДНК в клетках костного мозга; стимулирует эритро-, лейко-и тромбопоэз, поэтому многие лекарственные формы железа содержат ее в средних дозировках.…”

Section: Reproductive Health and Artunclassified

Effective preconception preparation for women with iron deficiency

et al. 2023

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Introduction. Latent iron deficiency, which has a high prevalence among women of childbearing age, most often, in the absence of therapy, progresses in pregnant women into manifest iron deficiency, manifested by clinical symptoms of anemia and associated with a complicated course of pregnancy, childbirth, the postpartum period, unfavorable outcomes of newborns. The above justifies the need for correction of iron deficiency at the preconception period.Aim. To evaluate the effectiveness of therapy latent iron deficiency at the stage of preconception period.Materials and methods. The study included 32 women at the stage of pregnancy planning with latent iron deficiency. All women taking the drug Ferretab 1 pill per day for 1 month. The level of blood parameters was assessed at 3 months before the intended conception, in the I, II and III trimesters of pregnancy, in the 3rd day after delivery. In newborns, the indicators of a clinical blood test were evaluated on the 2nd day after birth. We evaluated such indicators as the level of hemoglobin, erythrocytes, hematocrit, the average content of hemoglobin in erythrocytes, serum ferritin, serum iron, transferrin.Results. Evaluation of laboratory data in the course of the study confirmed the effectiveness of the use the complex drug Ferretab. Patients already at the first visit to the doctor during pregnancy had a positive trend and a significant increase in the level of hematological parameters.Conclusions. Oral administration of the complex drug Ferretab showed high efficiency in the treatment of latent iron deficiency at the stage of preconception period, significantly increasing the levels of hematological parameters, good tolerance and a small number of side effects, contribute to the high adherence of patients to therapy, which allows achieving significant clinical results.

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Efficacy of iron-folic acid treatment for reducing anemia prevalence and improving iron status in women of reproductive age: A one-year longitudinal study

Cited by 8 publications

References 27 publications

Haemoglobin diagnostic cut-offs for anaemia in Indian women of reproductive age

Haemoglobin diagnostic cut-offs for anaemia in Indian women of reproductive age

Dietary Patterns and Association with Anemia in Children Aged 9–16 Years in Guangzhou, China: A Cross-Sectional Study

Effective preconception preparation for women with iron deficiency

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