Efficacy of Juzen-taiho-to against vincristine-induced toxicity in          dogs

Shinohara, Yuta; Nishino, Yoko; Yamanaka, Megumi; Ohmori, Kitaro; Elbadawy, Mohamed; Usui, Tatsuya; Sasaki, Kenji

doi:10.1292/jvms.19-0401

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…An experimental study reported that Juzen-taiho-to ameliorated the carboplatin-induced decrease in food intake and BW in mice [16]. In our previous study, the administration of granulated Juzen-taiho-to to dogs promoted gastric contraction and reduced vincristine-induced gastrointestinal adverse reactions [14].…”

Section: Discussionmentioning

confidence: 85%

“…Juzen-taiho-to was reported to reduce the hematological side effects of anti-cancer drugs in mice [16]. In our previous study, Juzen-taiho-to stimulated gastric contraction and had protective effects against vincristine-induced gastrointestinal toxicity in dogs when administered at 450 mg/kg/day [14]. Considering these reports, Juzen-taiho-to may be useful in veterinary medicine to reduce the side effects of anti-cancer drugs.…”

Section: Introductionmentioning

confidence: 90%

“…Although traditional Chinese medicine has the possibility of being useful in veterinary medicine [14,15], it is sometimes difficult to administer to animals because of its unique smell and taste. Thus, we investigated Hozen-S palatability in the dogs.…”

Section: Palatability Assessment Of Hozen-s In Dogsmentioning

confidence: 99%

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Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastric motility in dogs

Shinohara

Elbadawy

Yamanaka

et al. 2022

The Journal of Veterinary Medical Science

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Juzen-taiho-to, a traditional Chinese herbal medicine, is used for patients with anorexia and fatigue in human medicine. In our previous study, granulated Juzen-taiho-to improved vincristine-induced gastrointestinal adverse effects through increasing gastric motility in dogs. As the effect of Hozen-S, the sweet liquid form of Juzen-taiho-to, on dog gastric motility has not been investigated, we examined the effect of administration of Hozen-S on gastric motility. Furthermore, we assessed dog plasma ghrelin level to further elucidate the mechanism of the effect of Hozen-S on gastric contraction.Finally, we assessed the palatability of Hozen-S compared to granulated Juzen-taiho-to and its effect on body weight in dogs. Administration of Hozen-S significantly increased gastric motility, plasma ghrelin concentration, and body weight. A palatability evaluation revealed that the dogs preferred Hozen-S to granulated Juzen-taiho-to. In conclusion, Hozen-S administration to dogs promoted gastric motility by raising plasma ghrelin levels. Considering these functional and palatability data, Hozen-S may replace granulated type Juzen-taiho-to and become a prominent traditional Chinese veterinary medicament.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 90%

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Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastric motility in dogs

Shinohara

Elbadawy

Yamanaka

et al. 2022

The Journal of Veterinary Medical Science

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Regulation of appetite-related neuropeptides by herbal medicines: research using microarray and network pharmacology

Lee,

Jang,

Lee

et al. 2023

Appl Biol Chem

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Anorexia means loss of appetite and is a state whereby a desire to eat is either reduced or eliminated resulting in reducing or stopping food intake. Sipjeondaebo-tang (SDT) and Hyangsayukgunja-tang (HYT) are prescriptions known to have appetite-improving effects, but studies on their mechanisms and active components are insufficient. The hypothalamus is the center of appetite control, and various appetite control mechanisms are known. We used mouse hypothalamic neuronal GT1-7 cells as appetite control center cells and analyzed the difference in efficacy between SDT and HYT using microarray and network pharmacology. Microarray analysis showed that SDT and HYT affect the regulation of genes related to appetite control in the digestive tract and central nervous system. Using network pharmacology, we analyzed the differential expression of neuropeptide Y receptors, glucagon, corticotropin-releasing hormone receptors 1, and 5-hydroxytryptamine receptor 4 among the 17 anorexia-related genes selected from the comparative toxicogenomics database and also analyzed the active components that affect gene expression. In conclusion, the appetite-related genes contributed to anorexia control, and the difference in the action mechanism of the two complex prescriptions could be explained.

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Efficacy of Olea europaea leaves and propolis extracts in the control of experimentally induced infectious bronchitis in broiler chickens

Sawsan¹,

Bahgat²,

Nada³

et al. 2023

Ger. J. Vet. Res.

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Infectious bronchitis (IB) is a viral disease that causes serious economic losses in the broiler industry. This study evaluated the effectiveness of Olea europaea leaves and propolis extracts (OLP) mixture at a rate of 400 μg and 100 mg/mL, respectively, in curing IB in broiler chickens. One-day-old Ross broiler chicks were randomized into four groups (G) of twenty-one chicks; G1 (control negative; no infection and treatment); G2 (no infection, treatment only), G3 (control positive; infection only and no treatment) and G4 (infection and treatment) that infected with IBv (106 EID50/ml) at 21 days old. The OLP treatment was applied for birds in G2 and G4 at a dose of 0.5 mL/liter drinking water for three successive days. The growth performance, clinical and pathological examinations and viral shedding were evaluated. The use of the OLP resulted in protection from IB infection through the significant improvement of performance parameters such as weight gain and feed conversion ratio, decrease in mortality rate, lowering disease severity, and rapid recovery from the observed clinical signs (mainly respiratory signs), gross and microscopic lesions in the trachea, lung, and kidneys as compared to those in the positive control (G3). Moreover, the viral shedding in the OLP-treated chicks (G4) was significantly decreased in tracheal and cloacal swabs to a rate less than 3×103 IBv genome copy number and became not detectable at 14-days post-infection (dpi) in their cloacal swabs. In conclusion, OLP can potentially display an antiviral effect against IB in broiler chickens. Therefore, adding OLP to the chicken drinking water is recommended to prevent and control IB.

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Efficacy of Juzen-taiho-to against vincristine-induced toxicity in dogs

Cited by 3 publications

References 12 publications

Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastric motility in dogs

Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastric motility in dogs

Regulation of appetite-related neuropeptides by herbal medicines: research using microarray and network pharmacology

Efficacy of Olea europaea leaves and propolis extracts in the control of experimentally induced infectious bronchitis in broiler chickens

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