Efficacy of L-Ornithine L-Aspartate in Patients With Esophageal Variceal Bleeding

Петрушенко, В. В.; Гребенюк, Д. І.; Lonskii, K. L.; Gladkykh, V. Y.; Kedyk, O. O.; Rosha, L. G.

doi:10.26724/2079-8334-2021-2-76-112-117

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…As can be seen from the results of our study, patients in all three groups during the first month showed an improvement in both laboratory indicators of liver function and integrated quality of life. A similar trend has been demonstrated in our earlier work [15]. This is due to the appointment of all patients admitted to inpatient treatment for gastrointestinal bleeding of portal origin, a comprehensive treatment aimed at improving not only the functional state of the liver but the patient's condition as a whole.…”

Section: Discussionsupporting

confidence: 81%

The Impact of Permanent Stress Caused by the War in Ukraine on the State of Patients With Portal Hypertension Due to Liver Cirrhosis

Petrushenko,

Grebeniuk,

Martsynkovskyi

et al. 2024

Clin. and prev. med.

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The aim of the study was to evaluate the impact of permanent stress and features of medical care in martial law on the indicators of liver function and quality of life of patients with portal hypertension due to liver cirrhosis. Materials and methods. The study included 37 patients with a confirmed diagnosis of liver cirrhosis complicated by portal hypertension and esophageal variceal bleeding. According to performed interventions all patients were divided into 3 groups: Group 1 – endoscopic band ligation and partial splenic artery embolization; Group 2 – endoscopic band ligation; Group 3 – endoscopic band ligation. The difference between Group 2 and Group 3 patients was that Group 2 patients were in a state of permanent stress due to the war. There were 4 visits with an interval of 1 month. At each time point, the levels of laboratory parameters of functional state of the liver and quality of life using RAND SF-36 questionnaire were evaluated. Results. Patients in all three groups during the first month showed an improvement in both laboratory indicators of liver function and integrated quality of life. In patients of Group 1 there was a progressive improvement in both the functional status of the liver and quality of life. In Group 2 the lack of any manipulations and maintenance therapy led to a lack of positive dynamics in patients. Staying in a state of permanent stress led to a progressive deterioration in the condition of patients in Group 3 starting from the second visit. Initially, the deterioration affected only the quality of life, but later it also manifested itself as a violation of the indicators of the functional state of the liver. Conclusions. The cumulative effect of permanent stress in patients with liver cirrhosis complicated by portal hypertension is manifested by an early deterioration in the quality of life with later violations of liver function.

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Section: Discussionsupporting

confidence: 81%

The Impact of Permanent Stress Caused by the War in Ukraine on the State of Patients With Portal Hypertension Due to Liver Cirrhosis

Petrushenko,

Grebeniuk,

Martsynkovskyi

et al. 2024

Clin. and prev. med.

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Efficacy of partial embolization of splenic artery in patients after hemorrhage of portal genesis

Петрушенко

Гребенюк

2022

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Objective. To assess the efficacy of partial embolization of splenic artery in patients after hemorrhage of portal genesis. Materials and methods. Into the investigation 39 patients with verified diagnosis of hepatic cirrhosis, complicated by portal hypertension and hemorrhage from widened varicose esophageal veins, were included. Into the first group (n=17) were included the patients, to whom endoscopic ligature of bleeding varicosities and partial embolization of splenic artery performed; into the second one (n=22) - patients, to whom independent endoscopic ligature of bleeding varicosities performed. The levels of laboratory indices, characterizing hepatic functional state, were assessed monthly. Results. In the first group upon a time a progressive statistically significant improvement of all indices investigated was noted. In the second group a statistically significant improvement of all indices was observed in a period between first and second visit. In further times the changes did not have a statistical significance. While conduction of multifactorial analysis of variance for investigation of embolia impact on the pigmentary metabolism and the system of hemostasis indices a trustworthiness of this impact had grown up upon a time and on the fourth visist became statistically significant. While investigation of the embolization impact on the level of hepatic enzymes and the proteins metabolism indices the trustworthiness of the dependence have been grown upon a time as well, but its gaining of statistical significance was observed on the third visit already. Conclusion. Postoperative period after performance of partial embolization of splenic artery in patients, suffering hemorrhage of portal genesis, is characterized by positive dynamics of laboratory indices in hepatic functional state.

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Efficacy of L-Ornithine L-Aspartate in Patients With Esophageal Variceal Bleeding

Cited by 2 publications

References 13 publications

The Impact of Permanent Stress Caused by the War in Ukraine on the State of Patients With Portal Hypertension Due to Liver Cirrhosis

The Impact of Permanent Stress Caused by the War in Ukraine on the State of Patients With Portal Hypertension Due to Liver Cirrhosis

Efficacy of partial embolization of splenic artery in patients after hemorrhage of portal genesis

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