Efficacy of lactase-treated milk for lactose-intolerant pediatric patients

Biller, Jeffrey A.; King, Sheila; Rosenthal, Andrea; Grand, Richard J.

doi:10.1016/s0022-3476(87)80351-7

Cited by 31 publications

(8 citation statements)

References 14 publications

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“…De acuerdo con los resultados encontrados con el protocolo aplicado en la presente serie de niños con diarrea aguda, la indicación teórica de un manejo específico según los criterios aceptados se circunscribiría a cinco casos con shigelosis (11.3% de las bacterias enteropatógenas identificadas y 4.7% del total de coprocultivos), siete casos con giardiasis y dos con amibiasis (2.4 y 0.7%, respectivamente, del total de estudios en fresco de heces); en relación con el número total de muestras estudiadas, este grupo de agentes identificados correspondió a 4.8% de los casos, con una indicación específica de manejo con antibióticos o antiparasitarios. La indicación de una fórmula sin lactosa -si se considera al hallazgo de pH ácido y sustancias reductoras en las heces como indicador de intolerancia a la lactosa- 8,35 en la serie estudiada correspondió a 17% del total de muestras estudiadas; este evento de mala absorción transitoria de hidratos de carbono se presentó casi exclusivamente en el grupo de niños menores a 19 meses de edad, y tuvo una alta asociación con la identificación de antígeno de rotavirus en las heces, variables que se pueden considerar como factores de riesgo.…”

Section: Discussionunclassified

Utilidad del estudio de las heces para el diagnóstico y manejo de lactantes y prescolares con diarrea aguda

Larrosa‐Haro¹,

Ruiz-Pérez²,

Aguilar-Benavides³

2002

Salud pública Méx

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Section: Discussionunclassified

Utilidad del estudio de las heces para el diagnóstico y manejo de lactantes y prescolares con diarrea aguda

Larrosa‐Haro¹,

Ruiz-Pérez²,

Aguilar-Benavides³

2002

Salud pública Méx

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“…Enzyme-replacement treatment with microbial exogenous lactase (obtained from yeasts or fungi) represents a possible strategy for primary lactase deficiency. However, while several studies have confirmed the efficacy of solid lactase preparations in reducing both H2 excretion and symptoms [12, 13], other comparative studies have shown that these preparations are significantly less effective than prehydrolysed milk, probably due to the gastric enzyme inactivation [14]. Since LI management with Beta-Galactosidase oral supplements remains unclear and data regarding their efficacy in reducing the H2 breath concentration are inadequate, the aim of the present investigation was to assess whether supplementation with a standard oral dose of Beta-Galactosidase obtained from Aspergillus oryzae affects hydrogen breath excretion and GI symptoms in lactose intolerant patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of Exogenous Lactase Administration on Hydrogen Breath Excretion and Intestinal Symptoms in Patients Presenting Lactose Malabsorption and Intolerance

Ibba

Gilli

Boi

et al. 2014

BioMed Research International

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Objective. To establish whether supplementation with a standard oral dose of Beta-Galactosidase affects hydrogen breath excretion in patients presenting with lactose malabsorption. Methods. Ninety-six consecutive patients positive to H2 Lactose Breath Test were enrolled. Mean peak H2 levels, the time to reach the peak H2, the time to reach the cut-off value of 20 ppm, the cumulative breath H2 excretion, the areas under the curve, and a Visual Analogical 10-point Scale for symptoms were calculated. Genotyping of the C/T-13910 variant was carried out. Results. Following the oral administration of Beta-Galactosidase, in 21.88% of the cases, H2 Lactose Breath Test became negative (Group A), while mean peak H2 levels (74.95 ppm versus 7.85), P < 0.0000, in 17.71% (Group B) were still positive, with the H2 level 20 ppm above the baseline, but the peak H2 levels were significantly lower than those observed at the baseline test (186.7 ppm versus 66.64), P < 0.0000, while in 60.41% (Group C) they were still positive with the peak H2 levels similar to those observed at the baseline test (94.43 versus 81.60 ppm). All 96 individuals tested presented the C/C-13910 genotype nonpersistence. Conclusions. The response to oral administration of Beta-Galactosidase in patients with symptoms of lactose malabsorption presents a significant variability.

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“…Unfortunately, although some of these studies underlined their interest, only few have examined their efficacy (Biller et al, 1987;Moskovitz et al, 1987;DiPalma and Collins, 1989;Sanders et al, 1992;Lin et al, 1993;Ramirez et al, 1994;Gao et al, 2002;Portincasa et al, 2008;Ojetti et al, 2010). However, the usefulness of solid β-galactosidase preparations is still discussed.…”

Section: Exogenous β-Galactosidasementioning

confidence: 99%

Recent advances on lactose intolerance: Tolerance thresholds and currently available answers

Corgneau

Scher

Ritié-Pertusa³

et al. 2017

Critical Reviews in Food Science and Nutrition

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The genetically programmed reduction in lactase activity during adulthood affects 70% of the world adult population and can cause severe digestive disorders, which are the sign of lactose intolerance. Lactose intolerance symptoms vary depending on the residual lactase activity, the small bowel transit time, and especially the amount of ingested lactose. To formulate dairy products suitable for the vast majority of lactose intolerants, it is essential to define lactose intolerance threshold. A recent meta-analysis permitted to show that almost all lactose intolerants tolerate 12 g of lactose in one intake and approximately 18 g of lactose spread over the day. The prevalence and severity of lactose intolerance are probably overestimated by the general public. This misconception usually leads to an unnecessary reduction of dairy foodstuff consumption. Nevertheless, dairy products are essential for health mainly due to their calcium content and the positive influence of probiotic bacteria. The formulation of dairy products suitable for most intolerant and suspicious subjects seems necessary. The use of exogenous enzyme preparations, as well as the consumption of lactose-free products or products rich in probiotic bacteria are proposed as symptom-reducing strategies.

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Efficacy of lactase-treated milk for lactose-intolerant pediatric patients

Cited by 31 publications

References 14 publications

Utilidad del estudio de las heces para el diagnóstico y manejo de lactantes y prescolares con diarrea aguda

Utilidad del estudio de las heces para el diagnóstico y manejo de lactantes y prescolares con diarrea aguda

Effects of Exogenous Lactase Administration on Hydrogen Breath Excretion and Intestinal Symptoms in Patients Presenting Lactose Malabsorption and Intolerance

Recent advances on lactose intolerance: Tolerance thresholds and currently available answers

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