Efficacy of Lansoprazole in the Treatment of Gastroesophageal Reflux Disease in Children

Tolia, Vasundhara; Ferry, George D.; Gunasekaran, Thirumazhisai S.; Huang, Bidan; Keith, Roberta; Book, Linda S.

doi:10.1097/00005176-200211004-00003

Cited by 75 publications

(65 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Over the last 15 years or so, proton pump inhibitor (PPI) therapy has been used with increasing frequency for short- [1][2][3][4][5] and long-term 6, 7 treatment of gastrooesophageal reflux disease (GERD) in children. Rates of symptom relief and healing of erosive oesophagitis are excellent, and long-term therapy is effective for maintaining remission.…”

Section: Introductionmentioning

confidence: 99%

Gastric histology in children treated with proton pump inhibitors long term, with emphasis on enterochromaffin cell-like hyperplasia

Hassall

Owen

Kerr

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Gastric histology in children treated with proton pump inhibitors long term, with emphasis on enterochromaffin cell-like hyperplasia

Hassall

Owen

Kerr

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

View full text Add to dashboard Cite

show abstract

“…Proton pump inhibitors (PPIs) are the most effective pharmacologic agents available for the treatment of children as well as adults with GER and GERD [9][10][11][12][13][14], with these agents being considered the mainstay of acid-related treatment [15]. Pediatric patients with GERD often have symptomatic relapse whenever attempts are made to discontinue treatment and this affects their lifestyle [16].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Proton Pump Inhibitor Use in Children: A Retrospective Review of Safety

Tolia

Boyer

2007

Dig Dis Sci

View full text Add to dashboard Cite

The objective of this work was to assess the efficacy of continuous proton pump inhibitor (PPI) therapy in children and to evaluate changes in biochemical, endoscopic, and histologic parameters during such treatment. A retrospective review of children receiving PPI therapy continuously for 1 year or more with baseline and follow-up esophageal and gastric biopsies on treatment was conducted to assess type, frequency, and duration of PPI dosing, symptom relief, gastrin levels, histologic findings, and adverse events. A total of 113 children (59 male, median age 4.5 years) were identified. Of these, 31% (35/113) were neurologically impaired. The median treatment duration was 35.2 months. Elevated serum gastrin levels occurred in 73% of children with no statistically significant differences in gastrin level by PPI type, dose, and dosing frequency or treatment duration. Adverse events were reported by 12% of children: diarrhea (5%) and constipation (4%) were the most frequent. Long-term PPI therapy appears to be effective, safe and well tolerated in children despite some biochemical, endoscopic, and histologic changes.

show abstract

“…Ollyo et al [49] reported further progression of the disease in 23% of patients with erosive esophagitis, improvement in 31% of children and spontaneous resolution in 46% of patients. Tolia et al [50] in the study on children with erosive esophagitis showed improvement in 78% of patients after 8-week anti-reflux treatment, and in 100% of patients after 12 weeks. Wakil et al [51] reported resolution of reflux esophagitis in 54,2%-87.9% of patients after 6-month conservative treatment.…”

Section: Discussionmentioning

confidence: 93%

Histological evaluation of esophageal mucosa in children with acid gastroesophageal reflux.

Semeniuk

Kaczmarski²,

Uścinowicz³

et al. 2009

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

AIM: histological evaluation of esophageal mucosa in children, with regard to the duration of primary acid gastroesophageal reflux (GER) and acid GER secondary to cow's milk allergy and/or other food allergy (CMA/FA) (prospective study). MATERIAL AND METHODS: 264 children of both sexes suspected of GER were enrolled in the study. The age of examined children was 1.5-102 months, mean age 20.78±17.23 months. Pathological acid GER was confirmed with pH-monitoring in 138 children (52.3%). Taking into consideration complex differential diagnosis, including oral food challenge test with potentially noxious nutrient (open or blind study), children were assigned into study groups 1 and 2 (primary and secondary GER). Group 1: 76 patients (28.8%) aged 4-102 months (x=25.2±27.28 months) with primary GER. Group 2: 62 patients (23.5%) aged 4-74 months (x=21.53±17.79 months) with GER secondary to CMA/FA. Children with GERD underwent preliminary and control (after 1 year and 2 years of GERD diagnosis) endoscopic examination of the upper gastroinestinal tract. RESULTS: Intensity of esophagitis was assessed initially in 25 children from group 1 (32.9%), in 29 children from group 2 (46.8%), and in 9 children from group 3 -reference group (28.1%). Histological evaluation revealed infiltration of inflammatory cells, mainly neutrophils and intraepithelial lymphocytes, and also eosinophils in 10 children (13.2%) with primary GER. Infiltration of eosinophils and lymphocytes was found in 5 children (8.1%) with secondary GER. In 8 children (25.0%) with food allergy there were only lymphocytes. Infiltration of neutrophils and lymphocytes and basal zone hyperplasia or infiltration of eosinophils and lymphocytes with elongation of lamina propria papillae was found in 10 children (13.1%) with primary GER and in 20 children (32.2%) with secondary GER. Differentiation of particular types of inflammatory cells in mucosal infiltration characterized histological picture in the following way: neutrophils in 21 children (27.6%) with primary GER, eosinophils in 22 children (35.5%) with secondary GER, lymphocytes in 15 children (19.7%) in children with primary GER and in 15 children (24.2%) with secondary GER. Histological examination of esophageal mucosa after 1 and 2 years of clinical observation and periodical conservative treatment in children with primary and secondary GER revealed significant alleviation of inflammatory abnormalities (with regard to the type of abnormalities and the number of particular types of inflammatory cells). CONCLUSIONS: The value of histological findings obtained in own studies comprises the role of food allergy in pathogenesis of GER and is related to GER's contribution, both direct (primary reflux) and indirect (secondary reflux), to triggering off morphological results and clinical outcomes of esophagitis.

show abstract

Efficacy of Lansoprazole in the Treatment of Gastroesophageal Reflux Disease in Children

Cited by 75 publications

References 0 publications

Gastric histology in children treated with proton pump inhibitors long term, with emphasis on enterochromaffin cell-like hyperplasia

Gastric histology in children treated with proton pump inhibitors long term, with emphasis on enterochromaffin cell-like hyperplasia

Long-Term Proton Pump Inhibitor Use in Children: A Retrospective Review of Safety

Histological evaluation of esophageal mucosa in children with acid gastroesophageal reflux.

Contact Info

Product

Resources

About