Efficacy of lansoprazole plus one or two antibiotics for Helicobacter pylori eradication

Jc, Soulé; Courrier, A.; Ma, Bin; Roux, Dominique; Mion, F.; Lamouliatte, H; Flejou, JF; Mégraud, F

doi:10.1016/0016-5085(95)23557-4

Cited by 3 publications

(1 citation statement)

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“…The original conversion of PPI dual to PPI triple therapy is the regimen consisting of omeprazole, 20 mg uid or bid, amoxicillin, 750 to 1,500 mg bid, and metronidazole, 250 to 500 mg bid, which was investigated in 14 treatment arms concerning 62 1 patients [30,72,99,122,145,156,171,176,. The mean cure rate was 79.7%.…”

Section: Ppi Triple Therapy Regimensmentioning

confidence: 99%

Treatment of Helicobacter pylori Infection: A Review of the World Literature

et al. 1996

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Section: Ppi Triple Therapy Regimensmentioning

confidence: 99%

Treatment of Helicobacter pylori Infection: A Review of the World Literature

et al. 1996

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Pharmacoeconomic Comparison of Treatments for the Eradication of Helicobacter pylori

Taylor¹

1997

Arch Intern Med

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Factors influencing Helicobacter pylori eradication with 2 week combination therapy of lansoprazole and amoxycillin: Intragastric distribution of colonization and gastric mucosal atrophy

Saita

Murakami

Takahashi

et al. 1998

J of Gastro and Hepatol

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In Japan, gastric ulcers are often accompanied by marked gastric mucosal atrophy. We evaluated the dual therapy of double-dose lansoprazole and amoxycillin for Helicobacter pylori eradication in Japanese ulcer patients and investigated the effects of intragastric distribution of H. pylori colonization and gastric mucosal atrophy on eradication with this combination therapy. Seventy-six H. pylori-positive ulcer patients received lansoprazole (30 mg) plus amoxycillin (500 mg) twice daily for 2 weeks (LA-60 group), lansoprazole (30 mg once daily) plus amoxycillin (500 mg twice daily) for 2 weeks (LA-30 group) or lansoprazole (30 mg once daily) for 6 or 8 weeks (LPZ group). Infection was evaluated by light microscopy, culture and biopsy urease tests. Helicobacter pylori colonization was classified as localized to the corpus (localized type) or involving the antrum and corpus (whole type). Fundic mucosal atrophy was graded according to endoscopic and histological features. Eradication was achieved in 67.6% in the LA-60 group, 31.6% in the LA-30 group, and 0% in the LPZ group, and moderate or severe histological gastritis was improved in the LA-60 group. Eradication was better in localized-type colonization (92%) than whole-type (56%), and better with fundic mucosal atrophy (84%) than without, but poor in both whole-type colonization and scanty mucosal atrophy (47%). The LA-60 therapy achieves better eradication in Japanese ulcer patients with localized H. pylori colonization and/or gastric mucosal atrophy, which are likely to be important predictors for the successful eradication with dual therapy.

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Efficacy of lansoprazole plus one or two antibiotics for Helicobacter pylori eradication

Cited by 3 publications

References 0 publications

Treatment of Helicobacter pylori Infection: A Review of the World Literature

Treatment of Helicobacter pylori Infection: A Review of the World Literature

Pharmacoeconomic Comparison of Treatments for the Eradication of Helicobacter pylori

Factors influencing Helicobacter pylori eradication with 2 week combination therapy of lansoprazole and amoxycillin: Intragastric distribution of colonization and gastric mucosal atrophy

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