Efficacy of Ledermix as a root canal medicament in symptomatic teeth: A clinical study

Kundabala, M; Jagadish, S; Ramya, S

doi:10.4103/2229-5194.142944

Cited by 7 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A third example is replacing a first‐generation tetracycline, such as demeclocycline in Ledermix paste (OzDent Dental Products Australia, Castle Hill, Australia), with a second‐generation tetracycline, such as doxycycline in Doxymix (OzDent Dental Products Australia). A typical vehicle used in such endodontic medicaments is polyethylene glycol 400, to which is added other excipients such as pH modifiers (Kundabala et al, 2014). Polyethylene glycol 400 used alone does not cause roots to darken (Athanassiadis et al, 2018).…”

Section: Formulation Changesmentioning

confidence: 99%

A critical analysis of research methods and experimental models to study tooth discolouration from endodontic materials

2022

View full text Add to dashboard Cite

As a range of materials used in endodontics may cause tooth discolouration, exploration of factors responsible for the darkening of the tooth crown or root is warranted. This narrative review paper discusses the range of technical factors that apply in laboratory studies that assess endodontic discolouration. As an example of how these factors operate, particular examples relating to discolouration caused by endodontic medicaments containing tetracycline antibiotics are used. Following the PRILE 2021 guideline approach, a summary of key variables to be addressed in the methodology for laboratory studies is presented, to inform future work.

show abstract

Section: Formulation Changesmentioning

confidence: 99%

A critical analysis of research methods and experimental models to study tooth discolouration from endodontic materials

2022

View full text Add to dashboard Cite

show abstract

“…The volume of eugenol used varied in different studies. Eugenol administration in cavities has been demonstrated to reduce pain within 72 hours [9]. No information was provided on the amount of eugenol used in this study.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

View full text Add to dashboard Cite

To determine the effective volume of eugenol on day 3 in the inflamed pulp. Methods: Experimental research with a posttest-only control group design The experimental animals used were 28 male Sprague-Dawley rats. The maxillary right molar tooth was prepared with a size of 1 mm and a depth of 1 mm. Eugenol was dropped on cotton pellets according to the treatment group, namely 0.1 µL, 0.08 µL, and 0.02 µL, and aquadest as a negative control was then put into the cavity and closed with a temporary seal. Rats were decapitated after 3 days, prepared, and stained with hematoxylin and eosin. Results were read with a 100x magnification microscope at 3 fields of view and with imageJ software. Results: The average number of macrophages in the cotton pellet application group with 0.1 µL eugenol volume was 22, the 0.08 µL eugenol volume group was 6.71, the 0.02 µL eugenol volume group was 44.43, and the negative control group was 34.29. The results of the one-way ANOVA test showed a significance of 0.000 (p<0.05). Conclusion: Eugenol volumes of 0.08 µL had the lowest average number of macrophages compared to eugenol volumes of 0.01 µL and 0.02 µL, and based on the post hoc test, there was a significant difference (p<0.05).

show abstract

“…Ledermix is a popular intracanal medication with a polyethylene glycol base that contains 1% triamcinolone and 3.2% demeclocycline. It has an anti-inflammatory effect because of the presence of corticosteroid (triamcinolone), and hence, it can be used to minimize pain or discomfort accompanying symptomatic apical periodontitis and to avoid symptomatic apical periodontitis flare-ups [ 16 ]. The antibiotic component of Ledermix (demeclocycline) counteracts the corticosteroid's suppression of the local immune response and minimizes the risk of infection [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has an anti-inflammatory effect because of the presence of corticosteroid (triamcinolone), and hence, it can be used to minimize pain or discomfort accompanying symptomatic apical periodontitis and to avoid symptomatic apical periodontitis flare-ups [ 16 ]. The antibiotic component of Ledermix (demeclocycline) counteracts the corticosteroid's suppression of the local immune response and minimizes the risk of infection [ 16 ]. Diapex Plus (DiaDent, Seoul, Korea) is yet another intracanal medication that has recently launched as a premixed paste consisting of 40.4% iodoform, 30.2% calcium hydroxide, and 22.4% silicone oil.…”

Section: Introductionmentioning

confidence: 99%

Comparing the Antifungal Effect of Sodium Hypochlorite Gel versus Different Types of Root Canal Medicaments at Different Time Intervals Using the Agar Diffusion Test: An In Vitro Study

Sayed

Ghanerad

Shabanpour

et al. 2021

International Journal of Dentistry

View full text Add to dashboard Cite

Aims. The purpose of this study was to compare the antifungal activity of sodium hypochlorite gel to those of four intracanal medicaments at various time intervals. Materials and Methods. The agar well diffusion technique was utilized to test the antifungal activity of the following medicaments against Candida albinans (C. albicans): sodium hypochlorite gel, chlorhexidine gel, calcium hydroxide paste, Ledermix, and Diapex Plus. The inhibition zone related to each medicine was measured in millimeter after 24, 48, and 72 hours of incubation at 37°C. The data were analyzed using one-way ANOVA and Games–Howell tests, at a significance level of P < 0.05 . Results. Except for Ledermix and Diapex Plus, which had no antifungal action, all of the medicaments showed varied inhibitory zones for C. albicans. At all periods, the NaOCl gel had the most significant inhibition zones, followed by the CHX gel and calcium hydroxide. At all time intervals, the NaOCl gel demonstrated comparable antifungal efficacy. When compared to a 24-hour time interval, the CHX gel showed an increased antifungal activity at the 48-hour and 72-hour intervals. Calcium hydroxide, on the other hand, showed a decrease in its antifungal activity at the 72-hour interval. Conclusion. The antifungal activity of sodium hypochlorite gel was the highest among the investigated medicaments. Chlorhexidine gel's antifungal activity improved over time, whereas calcium hydroxide's antifungal activity declined. Diapex Plus and Ledermix did not have any antifungal properties.

show abstract

Efficacy of Ledermix as a root canal medicament in symptomatic teeth: A clinical study

Cited by 7 publications

References 15 publications

A critical analysis of research methods and experimental models to study tooth discolouration from endodontic materials

A critical analysis of research methods and experimental models to study tooth discolouration from endodontic materials

Untitled

Comparing the Antifungal Effect of Sodium Hypochlorite Gel versus Different Types of Root Canal Medicaments at Different Time Intervals Using the Agar Diffusion Test: An In Vitro Study

Contact Info

Product

Resources

About