Efficacy of levocetirizine for the treatment of children with allergic rhinitis

Zheng, Peng-ju; Wang, Jinsheng; Liu, Guifang; Zhang, Shuhua; Zhang, Yiying

doi:10.1097/md.0000000000020557

Cited by 3 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mayinglong Babao eye paste is composed of calcinite, amber, artificial musk, artificial bezoar, pearl, borneol, and borax, which collectively exhibit properties such as clearing heat, reducing redness, alleviating itching, and providing shade [23][24] . It is used to address conditions caused by ocular heat disturbance, including redness, itching, and tearingAmong its components, the herbal medicine has calcinite, which has detoxifying properties and promotes eyesight while removing dampness and promoting the healing of sores.…”

Section: Discussionmentioning

confidence: 99%

Clinical Observation on the Combination of Ear Tip Bleeding and Babao Eye Ointment Ion Introduction in the Treatment of Needle Eye Heat Toxin Obstruction Syndrome

2024

FMSR

View full text Add to dashboard Cite

This study aimed to observe the clinical effects of ear tip exofusion combined withMayinglong Babao eye ointment in the treatment of needle eye conditions. From April 2022 to April 2023, a total of 120 patients (aged 6-25 years) with 120 affected eyes were diagnosed and treated at Ankang Eye Hospital. Using a random allocation method involving sequentially coding, opaque, and sealed envelopes, the patients were divided into an observation group and a control group, with 60 cases in each group. The control group received standard bleeding treatment, while the observation group underwent additional ear tip exofusion. Clinical efficacy, cure time, adverse reactions, and recurrence rates were compared between the two groups.Results showed that the total response rate in the observation group (91.67%) was significantly higher than that in the control group (83.33%) at the same time point (P < 0.05). Additionally, the cure time in the observation group was shorter than that in the control group, with a statistically significant difference (P < 0.05). No adverse events were reported in either group, and there was no statistically significant difference in the recurrence rate between the two groups (all P > 0.05). The combination of ear tip exofusion and Mayinglong Babao eye ointment demonstrated remarkable efficacy in treating needle eye conditions, suggesting its potential as a preferred external treatment option for such conditions, particularly in primary healthcare settings.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Observation on the Combination of Ear Tip Bleeding and Babao Eye Ointment Ion Introduction in the Treatment of Needle Eye Heat Toxin Obstruction Syndrome

2024

FMSR

View full text Add to dashboard Cite

show abstract

“…Левоцетиризин практично не чинить антихолінергічної та антисеротоні нової дії, не проникає через гематоенцефа лічний бар'єр. У терапевтичних дозах майже не виявляє седативного ефекту [15].…”

unclassified

Perennial allergic rhinitis in children: efficiency and safety of using «Ergocetal»

Уманец¹,

Lapshyn²,

Rudnev³

et al. 2021

UJPP

View full text Add to dashboard Cite

Purpose — to evaluate the efficacy and safety of levocetirizine («Ergocetal») in children with perennial allergic rhinitis (PAR). Materials and methods. 30 children aged 6–16 years with PAR were examined. All children were prescribed levocetirizine («Ergocetal») 5 mg in the form of tablets once a day for a month for the treatment of PAR. The criteria for the effectiveness of the treatment were: regression of the main nasal and ocular symptoms of PAR (rhinorrhea, nasal congestion, nasal itching, sneezing, itching and redness of the eyes) according to the visual analogue scale (VAS); dynamics of nasal eosinophilia in a smearst from the nasal mucosa. Results. The studies have shown that prescribe of levocetirizine «Ergocetal» in monotherapy for school-age children with mild and intermittent PAR had a positive therapeutic effect on nasal and ocular symptoms, as well as on the intensity of eosinophilic inflammation in the nasal mucosa. Established good tolerance and the absence of side effects of «Ergotal» in the examined children. Conclusions. Therapeutic efficacy, absence of adverse reactions, high adherence to treatment make it possible to recommend levocetirizine («Ergocetal») as monotherapy for mild and intermittent PAR in school children. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of an participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: allergic rhinitis, treatment, levocetirizine.

show abstract

Molecular mechanism of IL17A-IL17F involved in children with allergic rhinitis through IL17RC-IL33-NF-kB signaling axis

Qiao

2022

mat express

View full text Add to dashboard Cite

Objective: Allergic rhinitis (AR) is a common chronic nasal mucosal congestion disease of children, and its pathogenesis is associated with immune factors. Methods: 50 cases of children were collected and their nasal mucus was used to detect inflammatory factors IL-17A, IL-17F and IL-33 level, as well as the proportion of ILC2 and Th2 in blood labeled by flow cytometry. In addition, the allergic rhinitis model of immature mice was established. HE staining was used to observe nasal mucosa. IgE, IL-17A, IL-17F and IL-33 levels were detected, and the ratio of ILC2 and Th2 in blood was marked by flow cytometry. The expressions of IL17-RC, TRAF6, NF-kBp65 and MAPK protein in IL17RC-IL33-NF-kB signal pathway were measured by western blot. Results: The results indicated that IL-17A, IL-17F and IL-33 were significantly higher in children with allergic rhinitis and young model mice than that in control group. The content of CD4+IL-4+subgroup in Th2 in blood of model mice was high. The same trend as CD127+CD117+CRTH2+subgroup in ILC2. HE staining showed that the nasal mucosa of mice was intact in the control group, but the nasal mucosa epithelium of mice in the model group was destroyed. Conclusion: IL17-RC, TRAF6, NF-kBp65 and MAPK in nasal mucosal of model mice showed high expression, confirming that inflammatory factor IL17A-IL17F activated IL33 transcription through IL17RC and Activated ILC2 and Th2 cells involving in allergic inflammatory responses.

show abstract

Efficacy of levocetirizine for the treatment of children with allergic rhinitis

Cited by 3 publications

References 22 publications

Clinical Observation on the Combination of Ear Tip Bleeding and Babao Eye Ointment Ion Introduction in the Treatment of Needle Eye Heat Toxin Obstruction Syndrome

Clinical Observation on the Combination of Ear Tip Bleeding and Babao Eye Ointment Ion Introduction in the Treatment of Needle Eye Heat Toxin Obstruction Syndrome

Perennial allergic rhinitis in children: efficiency and safety of using «Ergocetal»

Molecular mechanism of IL17A-IL17F involved in children with allergic rhinitis through IL17RC-IL33-NF-kB signaling axis

Contact Info

Product

Resources

About