Efficacy of Liposomal Cytarabine in the Treatment of Leptomeningeal Metastasis of Breast Cancer

Laakmann, Elena; Witzel, Isabell; Müller, Volkmar

doi:10.1159/000464400

Cited by 13 publications

(27 citation statements)

References 12 publications

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“…However, cytarabine has not yet been investigated in cervical cancer, nor the rs5030743 and rs1130609 of RRM2. Although cytarabine differs from gemcitabine in several important respects ( 86 ), for instance, gemcitabine differs structurally from cytarabine by a fluorine group substituted at position 2′ on the furanose ring ( 87 ), gemcitabine ( 88 – 90 ) and cytarabine ( 91 , 92 ) can be a treatment for breast cancer. Hence, cytarabine may produce a similar effect to gemcitabine and could be an optional chemotherapeutic drug for treating cervical cancer by targeting rs5030743 and rs1130609 or other similar SNPs.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer

Liu

et al. 2019

Oncol Rep

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The present study was performed with the aim of understanding the mechanisms of pathogenesis and providing novel biomarkers for cervical cancer by constructing a regulatory circular (circ)RNA-micro (mi)RNA-mRNA network. Using an adjusted P-value of <0.05 and an absolute log value of fold-change >1, 16 and 156 miRNAs from GSE30656 and The Cancer Genome Atlas (TCGA), 5,321 mRNAs from GSE63514, 4,076 mRNAs from cervical squamous cell carcinoma and endocervical adenocarcinoma (from TCGA) and 75 circRNAs from GSE102686 were obtained. Using RNAhybrid, Venn and UpSetR plot, 12 circRNA-miRNA pairs and 266 miRNA-mRNA pairs were obtained. Once these pairs were combined, a circRNA-miRNA-mRNA network with 11 circRNA nodes, 4 miRNA nodes, 153 mRNA nodes and 203 edges was constructed. By constructing the protein-protein interaction network using Molecular Complex Detection scores >5 and >5 nodes, 7 hubgenes (RRM2, CEP55, CHEK1, KIF23, RACGAP1, ATAD2 and KIF11) were identified. By mapping the 7 hubgenes into the preliminary circRNA-miRNA-mRNA network, a circRNA-miRNA-hubgenes network consisting of 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519), 2 mRNAs (hsa-miR-15b and hsa-miR-106b) and 7 mRNAs (RRM2, CEP55, CHEK1, KIF23, RACGAP1, ATAD2 and KIF11) was constructed. There were 22 circRNA-miRNA-mRNA regulatory axes identified in the subnetwork. By analyzing the overall survival for the 7 hubgenes using the Gene Expression Profiling Interactive Analysis tool, higher expression of RRM2 was demonstrated to be associated with a significantly poorer overall survival. PharmGkb analysis identified single nucleotide polymorphisms (SNPs) of rs5030743 and rs1130609 of RRM2, which can be treated with cladribine and cytarabine. RRM2 was also indicated to be involved in the gemcitabine pathway. The 5 circRNAs (hsa_circRNA_000596, hsa_circRNA_104315, hsa_circRNA_400068, hsa_circRNA_101958 and hsa_circRNA_103519) may function as competing endogenous RNAs and serve critical roles in cervical cancer. In addition, cytarabine may produce similar effects to gemcitabine and may be an optional chemotherapeutic drug for treating cervical cancer by targeting rs5030743 and rs1130609 or other similar SNPs. However, the specific mechanism of action should be confirmed by further study.

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Section: Discussionmentioning

confidence: 99%

Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer

Liu

et al. 2019

Oncol Rep

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“…Mcl-1 expression in breast cancer cells is down-regulated by BAY 61-3606, making cancer cells more susceptible to TRAIL-mediated apoptosis [ 45 ]. It is feasible for LM patients with breast cancer to respond rapidly to the quick start of intracellular liposomal cytarabine treatment [ 46 ]. BI-2536 is a mitotic inhibitor that blocks the growth and invasion of cancer cells [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Construct ceRNA Network and Risk Model of Breast Cancer Using Machine Learning Methods under the Mechanism of Cuproptosis

Deng

Zhang

et al. 2023

Diagnostics

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Breast cancer (BRCA) has an undesirable prognosis and is the second most common cancer among women after lung cancer. A novel mechanism of programmed cell death called cuproptosis is linked to the development and spread of tumor cells. However, the function of cuproptosis in BRCA remains unknown. To this date, no studies have used machine learning methods to screen for characteristic genes to explore the role of cuproptosis-related genes (CRGs) in breast cancer. Therefore, 14 cuproptosis-related characteristic genes (CRCGs) were discovered by the feature selection of 39 differentially expressed CRGs using the three machine learning methods LASSO, SVM-RFE, and random forest. Through the PPI network and immune infiltration analysis, we found that PRNP was the key CRCG. The miRTarBase, TargetScan, and miRDB databases were then used to identify hsa-miR-192-5p and hsa-miR-215-5p as the upstream miRNA of PRNP, and the upstream lncRNA, CARMN, was identified by the StarBase database. Thus, the mRNA PRNP/miRNA hsa-miR-192-5p and hsa-miR-215-5p/lncRNA CARMN ceRNA network was constructed. This ceRNA network, which has not been studied before, is extremely innovative. Furthermore, four cuproptosis-related lncRNAs (CRLs) were screened in TCGA-BRCA by univariate Cox, LASSO, and multivariate Cox regression analysis. The risk model was constructed by using these four CRLs, and the risk score = C9orf163 * (1.8365) + PHC2-AS1 * (−2.2985) + AC087741.1 * (−0.9504) + AL109824.1 * (0.6016). The ROC curve and C-index demonstrated the superior predictive capacity of the risk model, and the ROC curve demonstrated that the AUC of 1-, 3-, and 5-year OS in all samples was 0.721, 0.695, and 0.633, respectively. Finally, 50 prospective sensitive medicines were screened with the pRRophetic R package, among which 17-AAG may be a therapeutic agent for high-risk patients, while the other 49 medicines may be suitable for the treatment of low-risk patients. In conclusion, our study constructs a new ceRNA network and a novel risk model, which offer a theoretical foundation for the treatment of BRCA and will aid in improving the prognosis of BRCA.

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“…44 It has been recommended that methotrexate, cytarabine, liposomal cytarabine and thiotepa are the most common options for IT therapy. 45–52…”

Section: Discussionmentioning

confidence: 99%

“…44 It has been recommended that methotrexate, cytarabine, liposomal cytarabine and thiotepa are the most common options for IT therapy. [45][46][47][48][49][50][51][52] Radiotherapy is an alternative treatment targeting bulky, symptomatic disease sites, particularly in the spine, with more efficacy and less toxicity than IT. 53,54 Despite not prolonging patient survival, radiotherapy can help facilitate IT use by restoring CSF flow and relieving hydrocephalus.…”

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine carcinoma of the breast with leptomeninges metastasis: A case report and literature review

et al. 2022

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Primary neuroendocrine carcinoma of the breast (NECB) is a rare tumour with an incident rate of 0.3–0.5%. The most common metastatic sites of NECB are liver, bones, lung, pancreas, soft tissues and brain, while leptomeninges metastasis (LM) is reported rarely. This current case report describes a 50-year-old female patient with NECB and LM whose overall survival was 2 months. The report also presents the current literature regarding the knowledge of this unusual tumour and metastatic type. The current patient was diagnosed with NECB with right cerebellar metastasis, followed by LM. She underwent modified radical mastectomy of the left breast, left whole breast radiation therapy and incomplete adjuvant chemotherapy until the metastasis occurred. Whole-brain radiation therapy and a first-line salvage regimen of etoposide and cis-platinum were then undertaken. The patient died 2 months after their LM diagnosis. Primary NECB with LM is sporadic, devoid of effective treatment and associated with a poor prognosis. Consequently, it is vitally important to identify LM in order to achieve longer patient survival.

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Efficacy of Liposomal Cytarabine in the Treatment of Leptomeningeal Metastasis of Breast Cancer

Cited by 13 publications

References 12 publications

Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer

Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer

Construct ceRNA Network and Risk Model of Breast Cancer Using Machine Learning Methods under the Mechanism of Cuproptosis

Primary neuroendocrine carcinoma of the breast with leptomeninges metastasis: A case report and literature review

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