Efficacy of local budesonide therapy in the management of persistent hyposmia in COVID-19 patients without signs of severity: A structured summary of a study protocol for a randomised controlled trial

Daval, Mary; Corré, Alain; Palpacuer, Clément; Housset, Juliette; Poillon, Guillaume; Eliezer, Michaël; Vérillaud, Benjamin; Slama, Dorsaf; Denis, Arnaud; Herman, Philippe; Jourdaine, Clément; Hervé, Camille; Bakkouri, W. El; Salmon, Dominique; Hautefort, Charlotte

doi:10.1186/s13063-020-04585-8

Cited by 17 publications

(10 citation statements)

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“…Given the capability of the SARS-CoV-2 of surviving over surfaces for several hours, it is crucial to perform an appropriate disinfection of the oral mucosa before any intervention [7], [8]. Furthermore, arising evidences exist about the positive action of antiviral and anti-allergic drugs in the oral district that seems to be useful in ameliorating the inflammatory status and reducing potential infection transmission.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, arising evidences exist about the positive action of antiviral and anti-allergic drugs in the oral district that seems to be useful in ameliorating the inflammatory status and reducing potential infection transmission. However, at least 10 clinical trials have been started to evaluate the efficacy and potential side effects of other products, including the ones used for oral hygiene [7], [8], [9].…”

Section: Introductionmentioning

confidence: 99%

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The Coronavirus Disease-19 Infection and the Oral Mucosa

Passarelli

Santacroce

D’Addona

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: The current coronavirus disease (COVID-19) pandemics induced a modification of daily life and clinical practice. Health care workers, particularly dentists and dental hygienists, have been obliged to limit their activity and to establish new operative protocols. AIM: We aimed to discuss an easy protocol for the prevention of cross-infections in dental settings. METHODS: We revised literature data about COVID-19 and oral health to establish how to work safely with dental patients. RESULTS AND CONCLUSION: A few papers are currently available about the effective prevention of COVID-19 during dental procedures. Most of the revised articles report a potential strong effectiveness of povidone-iodine and its safety for both patients and dental professionals.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Coronavirus Disease-19 Infection and the Oral Mucosa

Passarelli

Santacroce

D’Addona

et al. 2020

Open Access Maced J Med Sci

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“… 1 To date, clinical data on the use of systemic steroids regarding gastrointestinal symptoms in patients with COVID-19 is lacking, while the efficacy of topical budesonide in the clinical management of patients with COVID-19 infection has become available only for the treatment of prolonged anosmia. 16 …”

Section: Case Reportmentioning

confidence: 99%

Haemorrhagic ulcerative duodenitis in a patient with COVID-19 infection: clinical improvement following treatment with budesonide

Awwad

Greuel

Tacke

et al. 2021

BMJ Open Gastroenterol

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We present a case of a male patient in his mid-30s with COVID-19-induced lung failure requiring extracorporeal membrane oxygenation, who needed an emergency oesophagogastroduodenoscopy due to major upper gastrointestinal bleeding. Endoscopy exposed severe ulcerative duodenitis with diffuse mucosal bleeding. While CT angiography did not show any signs of ischaemia, histopathology revealed duodenitis with substantial inflammatory cell infiltrates consisting of neutrophils and CD3+ T lymphocytes with equal CD4+/CD8+ distribution. Since the composition of cell infiltrates coincides with changes in inflammatory patterns of the respiratory mucosa from patients with COVID-19 and in COVID-19-associated enterocolitis, and systemic dexamethasone treatment became standard of care in ventilated intensive care unit patients with COVID-19 infection, we initiated an individualised therapeutic attempt to treat the duodenitis with topical enteral budesonide. Follow-up oesophagogastroduodenoscopies within 4 weeks of enteral budesonide administration revealed a full clinical and histological healing of the duodenal mucosa with marked reduction of neutrophilic and lymphocytic infiltrates.To our knowledge, the current report is the first description of enteral budesonide treatment of duodenitis in a patient with COVID-19 infection and warrants further investigation, whether budesonide might constitute a novel therapeutic strategy for the management of COVID-19-related intestinal mucosal damage.

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“…A wide range of treatment modalities including olfactory training (OT), corticosteroid, theophylline, budesonide (nasal irrigation), intranasal calcium buffers, and antibiotics have been attempted to treat PVOD. [ 17 – 19 ] Among them, OT is the only evidence-based therapeutic option for PVOD. [ 15 ] Its application in PVOD shows promising results.…”

Section: Introductionmentioning

confidence: 99%

Smell disorders in COVID-19 patients: role of olfactory training

et al. 2021

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Background: As the coronavirus disease 2019 (COVID-19) spread around the world, a surge of evidence suggests that smell disorders are common symptoms in COVID-19 infection. This dysfunction may cause loss of appetite, malnutrition, poisoning, and depression. Obviously, the impairment has a strong impact on the quality of life. Therefore, there is an urgent need to identify effective treatments. Various therapies have been studied to treat smell disorders after infection, and olfactory training (OT) is considered a promising treatment option. Assessing the effectiveness and safety of olfactory training for COVID-19 patients with smell disorders is the main purpose of this systematic review protocol. Methods: PubMed, EMBASE, MEDLINE, the Cochrane Library, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database, ClinicalTrials.gov trials registry, and Chinese Clinical Trial Registry will be searched from January 2019 to January 2021. A combination of subject words and free text words will be applied in the searches. The language is limited to Chinese and English. The complete process will include study selection, data extraction, risk of bias assessment, and meta-analyses. Endnote X9.3 will be used to manage data screening. The statistical analysis will be completed by Review Manager V.5.3 (Cochrane Collaboration) or Stata V.16.0 software. Results: This proposed study will assess the effectiveness and safety of OT for COVID-19 patients with smell disorders. Conclusion: The conclusion of this study will provide evidence to prove the effectiveness and safety of olfactory training for COVID-19 patients with smell disorders. Ethics and dissemination: This protocol will not evaluate individual patient information or infringe patient rights and therefore does not require ethical approval. Registration: PEROSPERO CRD42020218009.

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Efficacy of local budesonide therapy in the management of persistent hyposmia in COVID-19 patients without signs of severity: A structured summary of a study protocol for a randomised controlled trial

Cited by 17 publications

References 0 publications

The Coronavirus Disease-19 Infection and the Oral Mucosa

The Coronavirus Disease-19 Infection and the Oral Mucosa

Haemorrhagic ulcerative duodenitis in a patient with COVID-19 infection: clinical improvement following treatment with budesonide

Smell disorders in COVID-19 patients: role of olfactory training

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