Efficacy of long-pulsed Nd-YAG laser in the treatment of nail psoriasis: a clinical and dermoscopic evaluation

Khashaba, Shrook A; Gamil, Hend; Salah, Reham; Salah, Eman

doi:10.1080/09546634.2019.1668908

Cited by 15 publications

(19 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding was consistent regardless of the type of lesion. These results contradict the previous findings by Khashaba et al [10]. This may be because the dermoscopic assessment in the present study relied on the visual expert opinion method, which is a subjective method with a high chance of low inter-rater reliability.…”

Section: Resultscontrasting

confidence: 99%

“…Laser energy started with 110 J/cm 2 in the first session and 130 J/cm 2 in the rest of the sessions, single pulse frequency, and shallow depth for up to 6 sessions. Khashaba and colleagues [10] utilized a 5 mm spot size and 40 J/cm² fluence, in partially overlapping mode in each session for 4 sessions. Kartal and colleagues [6] utilized a beam diameter 6 mm, laser energy was 10 J/cm 2 with 1.5 Hz repetition rate for 3 sessions Third, the limitations of the NAPSI score itself may represent another factor.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nd:YAG Laser in the Treatment of Nail Psoriasis: Clinical and Dermoscopic Assessment

Elwan

Azim

Starace

et al. 2021

Dermatol Pract Concept

View full text Add to dashboard Cite

Background: The Nd:YAG laser has emerged as a promising modality for the management of nail psoriasis owing to its ability for deep penetration of the skin surface, which has the advantage of destroying deep vessels. Objective: To assess the efficacy and safety of Nd:YAG laser in treating nail psoriasis. Methods: The present study was a randomized controlled study, conducted on 20 patients of both sexes (age older than 12 years) with mild to moderate psoriasis with nail involvement. We utilized facial telangiectasia parameters of Nd:YAG laser and beam diameter of 2.5 mm. Laser energy started with 110 J/cm2 in the first session and 130 J/cm2 in the rest of the sessions. Sessions were performed once monthly for up to 6 sessions. Results: We found no statistically significant difference in total Nail Psoriasis Severity Index (NAPSI) and nail bed scores before and after treatment among the treated group. However, there was statistically significant improvement in nail matrix score after treatment. On the other hand, the control group did not show any statistically significant changes for all scores throughout the study, except for the nail matrix score mean difference (0.35 ± 1.23 vs -1.00 ± 1.86 in the treated group). The degree of dermoscopic improvement was evident in the treated group (45% vs 25% in the control group). However, it was not statistically significant because of small sample size. The patients’ satisfaction and the external investigator’s assessment showed statistically significant negative correlation with total NAPSI mean difference in the treated group. Conclusion: The role of Nd:YAG laser in nail psoriasis is still controversial.

show abstract

Section: Resultscontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nd:YAG Laser in the Treatment of Nail Psoriasis: Clinical and Dermoscopic Assessment

Elwan

Azim

Starace

et al. 2021

Dermatol Pract Concept

View full text Add to dashboard Cite

show abstract

“…6 ). The long-pulsed 1064-nm Nd:YAG laser has already been successfully used in the treatment of nail psoriasis [ 10 – 12 ]. On the other hand, data on the efficacy of Nd:YAG laser in the treatment of plaque psoriasis are scarce and conflicting (Table 3 ) [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, increasing use of lasers in the treatment of inflammatory skin conditions is being observed. There are several reports demonstrating high effectiveness of the excimer laser in the treatment of plaque psoriasis [ 7 – 9 ], while the long-pulsed 1064 Nd:YAG laser has already been shown to be effective in the treatment of nail psoriasis [ 10 – 12 ]. The Nd:YAG laser may potentially be a good alternative to topical therapies due to its selective action on target areas or an additional option for patients with resistant psoriatic plaques.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Mild-to-Moderate Plaque Psoriasis with a New 650-Microsecond 1064-nm Nd:YAG Laser: Clinical and Dermoscopic Assessment

Kołt-Kamińska

Żychowska

Reich

2021

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Introduction About 70–80% of patients with psoriasis suffer from mild disease, and new modalities of topical treatment are urgently needed. This study aims to evaluate the effectiveness of 650-microsecond 1064-nm Nd:YAG laser in the therapy of psoriatic plaques and assess the utility of dermoscopy in predicting treatment response. Methods Ten patients (mean age 37.4 ± 16.2 years) with stable plaque-type psoriasis were enrolled. The microsecond Nd:YAG laser treatment was applied to representative plaques on day 0, 7, 14, and 21. Clinical and dermoscopic photographs were performed at each session and follow-up visit (day 28). The disease severity was assessed using modified Psoriasis Area and Severity Index (mPASI) and Investigator Global Assessment (IGA). Patients were asked to rate the intensity of subjective symptoms, tolerability, and final outcome of the treatment. Results Significant improvement of all mPASI components was observed, although the maximal mean reduction of total mPASI was only 30.3%. At baseline, three patients were assessed as “moderate” and seven as “mild” according to IGA, while on day 28, eight patients were scored as “mild” and two as “almost clear.” Complete resolution of itching was achieved in all patients. Local adverse reactions were also observed, which resulted in moderate tolerance of treatment in four patients. Three participants reported marked improvement on day 28, although 30% of patients observed no benefit. All subjects with dotted vessels, linear vessels, or hemorrhagic spots under dermoscopy at baseline reported some improvement after laser therapy. Three out of six patients with globular vessels were unresponsive to Nd:YAG laser. Conclusions Microsecond Nd:YAG laser treatment may provide some improvement of psoriatic plaques, but its routine applicability seems to be limited due to ambiguous efficacy and local adverse reactions. Dermoscopy may be useful in identifying patients who will benefit from the procedure.

show abstract

“…The Nd‐YAG laser is known for its high tissue penetration and its mechanism of action includes selective photothermolysis of hemoglobin in dermal vasculature 7 . According to Hochman, 8 Nd: YAG laser can cause fungal cellular damage and death by emitting 1.064‐nm wavelength energy that can pass through the nail plate and overheat the fungal material.…”

Section: Discussionmentioning

confidence: 99%

Treatment of pincer nail deformity with 1064‐nm Nd:YAG laser

Daye

Durmaz

2021

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Pincer nail (PN) is a nail disorder that cannot resolve spontaneously and sometimes necessitates surgical intervention. The etiological factors and gold standard treatment for the PN are still uncertain. We present a 24‐year‐old woman suffering from the PN and were treated with 1064‐nm long‐pulsed Nd:YAG laser. There were PN deformities in the left and right thumbnails. The left one was treated with four sessions of 1064‐nm. Nd:YAG laser.

show abstract

Efficacy of long-pulsed Nd-YAG laser in the treatment of nail psoriasis: a clinical and dermoscopic evaluation

Cited by 15 publications

References 24 publications

Nd:YAG Laser in the Treatment of Nail Psoriasis: Clinical and Dermoscopic Assessment

Nd:YAG Laser in the Treatment of Nail Psoriasis: Clinical and Dermoscopic Assessment

Treatment of Mild-to-Moderate Plaque Psoriasis with a New 650-Microsecond 1064-nm Nd:YAG Laser: Clinical and Dermoscopic Assessment

Treatment of pincer nail deformity with 1064‐nm Nd:YAG laser

Contact Info

Product

Resources

About