Efficacy of low-dose landiolol, an ultrashort-acting β-blocker, on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer

Nojiri, Takashi; Yamamoto, Kazuhide; Maeda, Hitoshi; Takeuchi, Yukiyasu; Funakoshi, Yasunobu; Maekura, Ryoji; Okumura, Meinoshin

doi:10.1007/s11748-011-0841-x

Cited by 26 publications

(27 citation statements)

References 23 publications

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“…Recently, more and more results showing the efficacy of landiolol in terminating postoperative atrial fibrillation [8,17,18]. Beta blockers reduce the rate of sudden death, and research has pointed to a beneficial effect in patients with ventricular tachyarrhythmias [19].…”

Section: Discussionmentioning

confidence: 99%

Continuous administration of landiolol reduced QT dispersion in postoperative patients

Suzuki

Numaguchi

Adachi

et al. 2014

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 99%

Continuous administration of landiolol reduced QT dispersion in postoperative patients

Suzuki

Numaguchi

Adachi

et al. 2014

Journal of Clinical Anesthesia

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“…Landiolol has also been shown to be well tolerated in the critically ill for its limited negative inotropic effect and minimal impact on blood pressure [99][100][101]. The use of low doses (5-10 mcg kg -1 min -1 ) of landiolol is usually sufficient for the cardioversion of AF compared to controls.…”

Section: Beta-blockersmentioning

confidence: 99%

Management of arrhythmia in sepsis and septic shock

Borggrefe¹,

Matoušek²,

Malý³

et al. 2017

Anaesthesiol Intensive Ther

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The occurrence of supraventricular arrhythmias is associated with an unfavourable prognosis in septic shock. Available trials are difficult to apply in sepsis and septic shock patients due to included cohorts, control groups and because "one size does not fit all". The priorities in the critically ill are maintenance of the sinus rhythm and diastolic ventricular filling. The rate control modality should be reserved for chronic AF and in situations when the sinus rhythm is difficult to maintain due to extreme stress conditions resulting from a high dosage of vasoactive agents. Electric cardioversion is indicated in unstable patients with an absence of contraindications and is more feasible in combination with an antiarrhythmic agent. Besides amiodarone being preferred for its lower cardiodepressant side effect compared to other agents, drugs with a different degree of betablocking activity are very useful in supraventricular arrhythmias and septic shock, providing echocardiography is routinely used to support their indications within the current summary of product characteristics. A typical patient benefiting from propafenone is without significant structural heart disease, i.e. typically with normal to moderately reduced left ventricular systolic function. Future research should be channelled towards echocardiography-guided prospective controlled trials on antiarrhythmic therapy which may clarify the issue of rhythm versus rate control, the effects of various antiarrhythmic drugs, and a place for electric cardioversion in critically ill patients in septic shock.

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“…In lung cancer, AF is most frequently seen during thoracic surgery, especially pulmonary resection [20]. Numerous studies in patients undergoing lung cancer surgery reported incidences of AF ranging 5.6%-23% [16,[21][22][23]. Previously, thoracic surgery was demonstrated to be an important risk factor for the occurrence of AF [24].…”

Section: Postoperative Af (Poaf) In Cancermentioning

confidence: 99%

Pathophysiology of cancer therapy-provoked atrial fibrillation

Cheng

Kao

Chen

et al. 2016

International Journal of Cardiology

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Efficacy of low-dose landiolol, an ultrashort-acting β-blocker, on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer

Abstract: Low-dose landiolol can be effective quickly and used safely in patients who develop atrial fibrillation after pulmonary resection for lung cancer.

Cited by 26 publications

References 23 publications

Continuous administration of landiolol reduced QT dispersion in postoperative patients

Continuous administration of landiolol reduced QT dispersion in postoperative patients

Management of arrhythmia in sepsis and septic shock

Pathophysiology of cancer therapy-provoked atrial fibrillation

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