Efficacy of Low-frequency Monophasic Pulsed Microcurrent Stimulation Therapy          in Undermining Pressure Injury: A Double-blind Crossover-controlled Study

Yoshikawa, Yoshiyuki; Hiramatsu, Terutaka; Sugimoto, Masaharu; Uemura, Mikiko; Mori, Yuichi; Ichibori, Ryoko

doi:10.2490/prm.20220045

Cited by 3 publications

(7 citation statements)

References 26 publications

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“…In this investigation, we aimed to find the relationship between the individual factors and the efficacy of MPMC therapy on pressure injuries with undermining. Our previous study [ 9 ] demonstrated that MPMC therapy was effective for patients with pressure injuries that have undermining. However, the effect exerted via MPMC varied among individuals, and some patients experienced more notable improvements than others.…”

Section: Discussionmentioning

confidence: 99%

“…For periodical pressure relieving and dispersal, postural change, positioning, and mattress selection were performed in accordance with the advisory panel’s guidelines [ 3 , 9 ]. Pressure injury wounds were cleansed once a day with a weakly acidic detergent and the undermining area was washed using an injector with tap water.…”

Section: Methodsmentioning

confidence: 99%

“…As a mechanism of its wound-healing effect, MPMC has been shown to promote fibroblast migration [ 7 ] and proliferation [ 8 ]. Interestingly, our clinical trial has demonstrated a significant reduction in wound size using MPMC in pressure injury patients with undermining [ 9 ]. Undermining is defined as the region underneath the overlying loose skin around a pressure injury.…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, the effect of MPMC may be influenced by patients’ individual factors affecting the condition of the tissue and cells in the wounds; scrutinizing physical factors that impact the clinical efficacy of MPMC is therefore essential for optimal clinical treatment. Hence, the present study performed an analysis using our previous clinical trial data [ 9 ], focusing on the relationship between wound healing and patients’ physical factors to explore the individual factors that affect the effectiveness of MPMC.…”

Section: Introductionmentioning

confidence: 99%

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Association between Patients’ Body Mass Index and the Effect of Monophasic Pulsed Microcurrent Stimulation on Pressure Injury Healing

Yoshikawa,

Maeshige,

Yamaguchi

et al. 2023

Biomedicines

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This secondary analysis study aimed to detect individual variables that influence the efficacy of monophasic pulsed microcurrent on pressure injury healing. Eleven patients with pressure injuries showing delayed healing underwent a microcurrent stimulation period and a placebo period. We analyzed the correlation between the individual variables and the following three outcomes using monophasic pulsed microcurrent: the wound reduction rate in the electrical stimulation period, the reduction rate in the placebo period, and the difference between these two reduction rates. Furthermore, the patients were divided into two groups, one with a wound reduction rate of more than 10% and the other with less than 10%, and the relationship between each variable was compared. As a result, the wound reduction rate in the electrical stimulation period and the difference in the reduction rate between the two periods showed significant positive correlations with patients’ body mass index. In addition, a significant difference was observed in the body mass index between subjects with a reduction rate of 10% or higher and those with a reduction rate of less than 10%. This study found a correlation between the effect of monophasic pulsed microcurrent for pressure injury healing and the level of patients’ body mass index.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Patients’ Body Mass Index and the Effect of Monophasic Pulsed Microcurrent Stimulation on Pressure Injury Healing

Yoshikawa,

Maeshige,

Yamaguchi

et al. 2023

Biomedicines

Self Cite

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“…It has demonstrated the ability to enhance the migration, proliferation, and differentiation of human dermal fibroblasts. Additionally, electrical stimulation has been observed to stimulate collagen synthesis, fibroblast proliferation, and migration [154]. Animal studies have shown its efficacy in promoting muscle and tendon regeneration, either alone [155,156] or as an adjunctive therapy [157,158].…”

Section: Microcurrent Therapymentioning

confidence: 99%

Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery

Lippi,

Ferrillo,

Losco

et al. 2024

Medicina

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Although rehabilitation medicine emphasizes a holistic health approach, there is still a large gap of knowledge about potential interventions aimed at improving overall wellbeing through cosmetic interventions. Therefore, this narrative review investigates the role of different rehabilitative techniques in enhancing aesthetics, quality of life, and psychosocial wellbeing for patients with disabilities. The study follows the SANRA framework quality criteria for a narrative review. Literature searches across PubMed/Medline, Web of Science, and Scopus identified articles focusing on rehabilitation strategies within the aesthetic rehabilitation domain. The review identified evidence supporting injection procedures, such as Botulinum Toxin, Platelet-Rich Plasma, Hyaluronic Acid, Ozone, and Carboxytherapy, and assessing their applications in several disabling disorders. Additionally, physical therapies like Extracorporeal Shock Wave Therapy, Laser Therapy, Microcurrent Therapy, Tecar Therapy, and physical exercises were explored for their impact on cutaneous microcirculation, cellulite treatment, wound healing, and scar appearance improvement. Lastly, the manuscript underlines the role of manual therapy techniques in addressing both physical discomfort and aesthetic concerns, discussing their effectiveness in adipose tissue therapy, scar tissue mobilization, and regional fat thickness reduction. Taken together, this review emphasizes the role of a multidisciplinary approach, aiming to provide valuable insights into potential benefits for both functional and aesthetic outcomes.

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Electrical stimulation facilitates NADPH production in pentose phosphate pathway and exerts an anti-inflammatory effect in macrophages

Uemura,

Maeshige,

Yamaguchi

et al. 2023

Sci Rep

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Macrophages play an important role as effector cells in innate immune system. Meanwhile, macrophages activated in a pro-inflammatory direction alter intracellular metabolism and damage intact tissues by increasing reactive oxygen species (ROS). Electrical stimulation (ES), a predominant physical agent to control metabolism in cells and tissues, has been reported to exert anti-inflammatory effect on immune cells. However, the mechanism underlying the anti-inflammatory effects by ES is unknown. This study aimed to investigate the effect of ES on metabolism in glycolytic-tricarboxylic acid cycle (TCA) cycle and inflammatory responses in macrophages. ES was performed on bone marrow-derived macrophages and followed by a stimulation with LPS. The inflammatory cytokine expression levels were analyzed by real-time polymerase chain reaction and ELISA. ROS production was analyzed by CellRox Green Reagent and metabolites by capillary electrophoresis-mass spectrometry. As a result, ES significantly reduced proinflammatory cytokine expression levels and ROS generation compared to the LPS group and increased glucose-1-phosphate, a metabolite of glycogen. ES also increased intermediate metabolites of the pentose phosphate pathway (PPP); ribulose-5-phosphate, rebose-5 phosphate, and nicotinamide adenine dinucleotide phosphate, a key factor of cellular antioxidation systems, as well as α-Ketoglutarate, an anti-oxidative metabolite in the TCA cycle. Our findings imply that ES enhanced NADPH production with enhancement of PPP, and also decreased oxidative stress and inflammatory responses in macrophages.

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Efficacy of Low-frequency Monophasic Pulsed Microcurrent Stimulation Therapy in Undermining Pressure Injury: A Double-blind Crossover-controlled Study

Cited by 3 publications

References 26 publications

Association between Patients’ Body Mass Index and the Effect of Monophasic Pulsed Microcurrent Stimulation on Pressure Injury Healing

Association between Patients’ Body Mass Index and the Effect of Monophasic Pulsed Microcurrent Stimulation on Pressure Injury Healing

Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery

Electrical stimulation facilitates NADPH production in pentose phosphate pathway and exerts an anti-inflammatory effect in macrophages

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